Search Results - "Lemckert, F A"

Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair by Redpath, G M I, Woolger, N, Piper, A K, Lemckert, F A, Lek, A, Greer, P A, North, K N, Cooper, S T

“…Dysferlin and calpain are important mediators of the emergency response to repair plasma membrane injury. Our previous research revealed that membrane injury…”
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Gene targeting in C57BL/6 ES cells. Successful germ line transmission using recipient BALB/c blastocysts developmentally matured in vitro by Lemckert, Frances A., Sedgwick, Jonathon D., Körner, Heinrich

“…There are significant advantages to the production of gene-knockout mice directly in mouse strains other than 129. The availability now of ES cells derived…”
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Unimpaired Autoreactive T-Cell Traffic Within the Central Nervous System During Tumor Necrosis Factor Receptor-Mediated inhibition of Experimental Autoimmune Encephalomyelitis by Korner, Heinrich, Goodsall, Anna L., Lemckert, Frances A., Scallon, Bernard J., Ghrayeb, John, Ford, Andrew L., Sedgwick, Jonathon D.

“…The critical role of tumor necrosis factor (TNF) as a mediator in autoimmune inflammatory processes is evident from in vivo studies with TNF-blocking agents…”
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Microglia induce CD4 T lymphocyte final effector function and death by Ford, A L, Foulcher, E, Lemckert, F A, Sedgwick, J D

“…Microglia, a type of tissue macrophage, are the only cells in the central nervous system (CNS) parenchyma to express some major histocompatibility complex…”
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Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue by Körner, H, Cook, M, Riminton, D S, Lemckert, F A, Hoek, R M, Ledermann, B, Köntgen, F, Fazekas de St Groth, B, Sedgwick, J D

“…Specialized roles for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice…”
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Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting by Körner, H, Riminton, D S, Strickland, D H, Lemckert, F A, Pollard, J D, Sedgwick, J D

“…Tumor necrosis factor (TNF)-dependent sites of action in the generation of autoimmune inflammation have been defined by targeted disruption of TNF in the…”
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Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice by Sean Riminton, D, Körner, H, Strickland, D H, Lemckert, F A, Pollard, J D, Sedgwick, J D

“…Lymphotoxin (LT) is widely regarded as a proinflammatory cytokine with activities equivalent to tumor necrosis factor (TNF). The contribution of LT to…”
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Tumor necrosis factor blockade in actively induced experimental autoimmune encephalomyelitis prevents clinical disease despite activated T cell infiltration to the central nervous system by Körner, H, Lemckert, F A, Chaudhri, G, Etteldorf, S, Sedgwick, J D

“…Recently, we demonstrated that experimental autoimmune encephalomyelitis (EAE) in the rat, passively transferred using myelin basic protein (MBP)-reactive…”
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Membrane lymphotoxin contributes to anti‐leishmanial immunity by controlling structural integrity of lymphoid organs by Wilhelm, Patricia, Riminton, D. Sean, Ritter, Uwe, Lemckert, Frances A., Scheidig, Christina, Hoek, Robert, Sedgwick, Jonathon D., Körner, Heinrich

“…Lymphotoxin (LT)α in combination with LTβ forms membrane‐bound heterotrimeric complexes with a crucial function in lymph node (LN) organogenesis and correct…”
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Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice by Cook, M C, Körner, H, Riminton, D S, Lemckert, F A, Hasbold, J, Amesbury, M, Hodgkin, P D, Cyster, J G, Sedgwick, J D, Basten, A

“…Secondary lymphoid tissue organogenesis requires tumor necrosis factor (TNF) and lymphotoxin alpha (LTalpha). The role of TNF in B cell positioning and…”
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Lymphotoxin controls αEβ7‐integrin expression by peripheral CD8+ T cells by Gabor, MJ, Sedgwick, JD, Lemckert, FA, Godfrey, DI, Körner, H

“…Lymphotoxin (LT)‐α, a member of the TNF family, is recognized as an important mediator in different aspects of lymphoid organ development. Targeted disruption…”
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Lymphotoxin controls alphaEbeta7-integrin expression by peripheral CD8+ T cells by Gabor, M J, Sedgwick, J D, Lemckert, F A, Godfrey, D I, Körner, H

“…Lymphotoxin (LT)-alpha, a member of the TNF family, is recognized as an important mediator in different aspects of lymphoid organ development. Targeted…”
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