Search Results - "Lemcke, Heiko"

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies by Müller, Paula, Lemcke, Heiko, David, Robert

“…A large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases. Since the…”
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Gap junctional shuttling of miRNA — A novel pathway of intercellular gene regulation and its prospects in clinical application by Lemcke, Heiko, Steinhoff, Gustav, David, Robert

“…The gap junctional exchange of small molecules between adjacent cells is crucial for maintaining tissue homeostasis and for a large number of cellular…”
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Recent Progress in Stem Cell Modification for Cardiac Regeneration by David, Robert, Steinhoff, Gustav, Voronina, Natalia, Lemcke, Heiko

“…During the past decades, stem cell-based therapy has acquired a promising role in regenerative medicine. The application of novel cell therapeutics for the…”
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hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us by Kussauer, Sophie, David, Robert, Lemcke, Heiko

“…Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CM) have been intensively used in drug development and disease modeling. Since…”
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Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells by Haack, Fiete, Lemcke, Heiko, Ewald, Roland, Rharass, Tareck, Uhrmacher, Adelinde M

“…Canonical WNT/β-catenin signaling is a central pathway in embryonic development, but it is also connected to a number of cancers and developmental disorders…”
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Sarcomeric network analysis of ex vivo cultivated human atrial appendage tissue using super-resolution microscopy by Chabanovska, Oleksandra, Lemcke, Heiko, Lang, Hermann, Vollmar, Brigitte, Dohmen, Pascal M., David, Robert, Etz, Christian, Neßelmann, Catharina

“…Investigating native human cardiac tissue with preserved 3D macro- and microarchitecture is fundamental for clinical and basic research. Unfortunately, the low…”
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Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors by Salewski, Inken, Henne, Julia, Engster, Leonie, Schneider, Bjoern, Lemcke, Heiko, Skorska, Anna, Berlin, Peggy, Henze, Larissa, Junghanss, Christian, Maletzki, Claudia

“…Tumors arising in the context of Lynch Syndrome or constitutional mismatch repair deficiency are hypermutated and have a good response towards…”
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Quantitative Evaluation of the Sarcomere Network of Human hiPSC-Derived Cardiomyocytes Using Single-Molecule Localization Microscopy by Lemcke, Heiko, Skorska, Anna, Lang, Cajetan Immanuel, Johann, Lisa, David, Robert

“…The maturation of iPSC-derived cardiomyocytes is still a critical point for their application in cardiovascular research as well as for their clinical use…”
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Expedient assessment of post-infarct remodeling by native cardiac magnetic resonance imaging in mice by Lang, Cajetan Immanuel, Vasudevan, Praveen, Döring, Piet, Gäbel, Ralf, Lemcke, Heiko, Lindner, Tobias, Steinhoff, Gustav, Krause, Bernd Joachim, Vollmar, Brigitte, Meinel, Felix G., Yücel, Seyrani, Öner, Alper, Ince, Hüseyin, David, Robert

“…Novel therapeutic strategies aiming at improving the healing process after an acute myocardial infarction are currently under intense investigation. The mouse…”
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Monitoring the maturation of the sarcomere network: a super-resolution microscopy-based approach by Skorska, Anna, Johann, Lisa, Chabanovska, Oleksandra, Vasudevan, Praveen, Kussauer, Sophie, Hillemanns, Maximilian, Wolfien, Markus, Jonitz-Heincke, Anika, Wolkenhauer, Olaf, Bader, Rainer, Lang, Hermann, David, Robert, Lemcke, Heiko

“…The in vitro generation of human cardiomyocytes derived from induced pluripotent stem cells (iPSC) is of great importance for cardiac disease modeling,…”
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CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors by Salewski, Inken, Henne, Julia, Engster, Leonie, Krone, Paula, Schneider, Bjoern, Redwanz, Caterina, Lemcke, Heiko, Henze, Larissa, Junghanss, Christian, Maletzki, Claudia

“…Mismatch repair-deficient (dMMR) tumors show a good response toward immune checkpoint inhibitors (ICI), but developing resistance impairs patients' outcomes…”
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The Effects of Hypoxic Preconditioned Murine Mesenchymal Stem Cells on Post-Infarct Arrhythmias in the Mouse Model by Ahmad, Beschan, Skorska, Anna, Wolfien, Markus, Sadraddin, Haval, Lemcke, Heiko, Vasudevan, Praveen, Wolkenhauer, Olaf, Steinhoff, Gustav, David, Robert, Gaebel, Ralf

“…Ventricular arrhythmias associated with myocardial infarction (MI) have a significant impact on mortality in patients following heart attack. Therefore,…”
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Multi-modal assessment of a cardiac stem cell therapy reveals distinct modulation of regional scar properties by Schweins, Moritz, Gäbel, Ralf, Raitza, Matti, Vasudevan, Praveen, Lemcke, Heiko, Joksch, Markus, Schildt, Anna, Kurth, Jens, Lindner, Tobias, Meinel, Felix G, Öner, Alper, Ince, Hüseyin, Vollmar, Brigitte, Krause, Bernd Joachim, David, Robert, Lang, Cajetan Immanuel

“…The initial idea of functional tissue replacement has shifted to the concept that injected cells positively modulate myocardial healing by a non-specific…”
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CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation by Vasudevan, Praveen, Wolfien, Markus, Lemcke, Heiko, Lang, Cajetan Immanuel, Skorska, Anna, Gaebel, Ralf, Galow, Anne-Marie, Koczan, Dirk, Lindner, Tobias, Bergmann, Wendy, Mueller-Hilke, Brigitte, Vollmar, Brigitte, Krause, Bernd Joachim, Wolkenhauer, Olaf, Steinhoff, Gustav, David, Robert

“…The immune response is a crucial factor for mediating the benefit of cardiac cell therapies. Our previous research showed that cardiomyocyte transplantation…”
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detectCilia: An R Package for Automated Detection and Length Measurement of Primary Cilia by Budde-Sagert, Kai, Krueger, Simone, Sehlke, Clemens, Lemcke, Heiko, Jonitz-Heincke, Anika, David, Robert, Bader, Rainer, Uhrmacher, Adelinde M

“…The primary cilium is a small protrusion found on most mammalian cells. It acts as a cellular antenna, being involved in various cell signaling pathways. The…”
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BPIFB4 and its longevity-associated haplotype protect from cardiac ischemia in humans and mice by Cattaneo, Monica, Aleksova, Aneta, Malovini, Alberto, Avolio, Elisa, Thomas, Anita, Alvino, Valeria Vincenza, Kilcooley, Michael, Pieronne-Deperrois, Marie, Ouvrard-Pascaud, Antoine, Maciag, Anna, Spinetti, Gaia, Kussauer, Sophie, Lemcke, Heiko, Skorska, Anna, Vasudevan, Praveen, Castiglione, Stefania, Raucci, Angela, David, Robert, Richard, Vincent, Beltrami, Antonio Paolo, Madeddu, Paolo, Puca, Annibale Alessandro

“…Long-living individuals (LLIs) escape age-related cardiovascular complications until the very last stage of life. Previous studies have shown that a…”
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Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart by Klopsch, Christian, Skorska, Anna, Ludwig, Marion, Lemcke, Heiko, Maass, Gabriela, Gaebel, Ralf, Beyer, Martin, Lux, Cornelia, Toelk, Anita, Müller, Karina, Maschmeier, Christian, Rohde, Sarah, Mela, Petra, Müller-Hilke, Brigitte, Jockenhoevel, Stefan, Vollmar, Brigitte, Jaster, Robert, David, Robert, Steinhoff, Gustav

“…Ischemic heart failure is the leading cause of mortality worldwide. An early boost of intracardiac regenerative key mechanisms and angiogenetic niche signaling…”
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Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes by Thiele, Frauke, Voelkner, Christin, Krebs, Vivien, Müller, Paula, Jung, Julia Jeannine, Rimmbach, Christian, Steinhoff, Gustav, Noack, Thomas, David, Robert, Lemcke, Heiko

“…The availability of truly maturated cardiomyocytic subtypes is a major prerequisite for cardiovascular cell replacement therapies. Pluripotent stem cells…”
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Cardiac Mesenchymal Stem Cells Proliferate Early in the Ischemic Heart by Klopsch, Christian, Skorska, Anna, Ludwig, Marion, Gaebel, Ralf, Lemcke, Heiko, Kleiner, Gabriela, Beyer, Martin, Vollmar, Brigitte, David, Robert, Steinhoff, Gustav

“…Cardiac mesenchymal stem cells (MSCs) could stimulate cell-specific regenerative mechanisms after myocardial infarction (MI) depending on spatial origin,…”
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Cardiomyocyte Transplantation after Myocardial Infarction Alters the Immune Response in the Heart by Vasudevan, Praveen, Wolfien, Markus, Lemcke, Heiko, Lang, Cajetan Immanuel, Skorska, Anna, Gaebel, Ralf, Koczan, Dirk, Lindner, Tobias, Engelmann, Robby, Vollmar, Brigitte, Krause, Bernd Joachim, Wolkenhauer, Olaf, Lang, Hermann, Steinhoff, Gustav, David, Robert

“…We investigated the influence of syngeneic cardiomyocyte transplantation after myocardial infarction (MI) on the immune response and cardiac function. Methods…”
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