Search Results - "Lemberg, Marius K"

Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms by Lemberg, Marius K., Strisovsky, Kvido

“…Protein homeostasis mechanisms are fundamentally important to match cellular needs and to counteract stress conditions. A fundamental challenge is to…”
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Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments by Lichtenthaler, Stefan F, Lemberg, Marius K, Fluhrer, Regina

“…Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐translational modification that controls levels and function of hundreds of…”
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Ubiquitin-Dependent Intramembrane Rhomboid Protease Promotes ERAD of Membrane Proteins by Fleig, Lina, Bergbold, Nina, Sahasrabudhe, Priyanka, Geiger, Beate, Kaltak, Lejla, Lemberg, Marius K.

“…The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to…”
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Clipping or Extracting: Two Ways to Membrane Protein Degradation by Avci, Dönem, Lemberg, Marius K

“…Protein degradation is a fundamentally important process that allows cells to recognize and remove damaged protein species and to regulate protein abundance…”
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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking by Meissner, Cathrin, Lorenz, Holger, Weihofen, Andreas, Selkoe, Dennis J., Lemberg, Marius K.

“…J. Neurochem. (2011) 117, 856–867. Intramembrane proteolysis is a conserved mechanism that regulates a variety of cellular processes ranging from transcription…”
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Functional and evolutionary implications of enhanced genomic analysis of rhomboid intramembrane proteases by Lemberg, Marius K, Freeman, Matthew

“…Rhomboids are a recently discovered family of widely distributed intramembrane serine proteases. They have diverse biological functions, including the…”
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Cooperation of mitochondrial and ER factors in quality control of tail-anchored proteins by Dederer, Verena, Khmelinskii, Anton, Huhn, Anna Gesine, Okreglak, Voytek, Knop, Michael, Lemberg, Marius K

“…Tail-anchored (TA) proteins insert post-translationally into the endoplasmic reticulum (ER), the outer mitochondrial membrane (OMM) and peroxisomes. Whereas…”
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RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling by Knopf, Julia D., Steigleder, Susanne S., Korn, Friederike, Kühnle, Nathalie, Badenes, Marina, Tauber, Marina, Theobald, Sebastian J., Rybniker, Jan, Adrain, Colin, Lemberg, Marius K.

“…The toll-like receptor 4 (TLR4) is a central regulator of innate immunity that primarily recognizes bacterial lipopolysaccharide cell wall constituents to…”
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Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation by Knopf, Julia D, Landscheidt, Nina, Pegg, Cassandra L, Schulz, Benjamin L, Kühnle, Nathalie, Chao, Chao-Wei, Huck, Simon, Lemberg, Marius K

“…The endoplasmic reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated…”
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Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers by Khmelinskii, Anton, Meurer, Matthias, Ho, Chi-Ting, Besenbeck, Birgit, Füller, Julia, Lemberg, Marius K, Bukau, Bernd, Mogk, Axel, Knop, Michael

“…Tandem fluorescent protein timers (tFTs) report on protein age through time-dependent change in color, which can be exploited to study protein turnover and…”
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The Yeast ER-Intramembrane Protease Ypf1 Refines Nutrient Sensing by Regulating Transporter Abundance by Avci, Dönem, Fuchs, Shai, Schrul, Bianca, Fukumori, Akio, Breker, Michal, Frumkin, Idan, Chen, Chia-yi, Biniossek, Martin L., Kremmer, Elisabeth, Schilling, Oliver, Steiner, Harald, Schuldiner, Maya, Lemberg, Marius K.

“…Proteolysis by aspartyl intramembrane proteases such as presenilin and signal peptide peptidase (SPP) underlies many cellular processes in health and disease…”
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Genome-wide C-SWAT library for high-throughput yeast genome tagging by Meurer, Matthias, Duan, Yuanqiang, Sass, Ehud, Kats, Ilia, Herbst, Konrad, Buchmuller, Benjamin C., Dederer, Verena, Huber, Florian, Kirrmaier, Daniel, Štefl, Martin, Van Laer, Koen, Dick, Tobias P., Lemberg, Marius K., Khmelinskii, Anton, Levy, Emmanuel D., Knop, Michael

“…Here we describe a C-SWAT library for high-throughput tagging of Saccharomyces cerevisiae open reading frames (ORFs). In 5,661 strains, we inserted an acceptor…”
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The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase by Yücel, Sara Suna, Stelzer, Walter, Lorenzoni, Alessandra, Wozny, Manfred, Langosch, Dieter, Lemberg, Marius K.

“…Unspliced XBP1 mRNA encodes XBP1u, the transcriptionally inert variant of the unfolded protein response (UPR) transcription factor XBP1s. XBP1u targets its…”
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Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18 by Prod'homme, Virginie, Tomasec, Peter, Cunningham, Charles, Lemberg, Marius K, Stanton, Richard J, McSharry, Brian P, Wang, Eddie C Y, Cuff, Simone, Martoglio, Bruno, Davison, Andrew J, Braud, Véronique M, Wilkinson, Gavin W G

“…Human CMV (HCMV)-encoded NK cell-evasion functions include an MHC class I homolog (UL18) with high affinity for the leukocyte inhibitory receptor-1 (CD85j,…”
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Cutting Proteins within Lipid Bilayers: Rhomboid Structure and Mechanism by Lemberg, Marius K., Freeman, Matthew

“…Rhomboids were only discovered to be novel proteases in 2001, but progress on understanding this newest family of intramembrane proteases has been rapid. They…”
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Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease by Weihofen, Andreas, Binns, Kathleen, Lemberg, Marius K., Ashman, Keith, Martoglio, Bruno

“…Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. In humans, SPP…”
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Transmembrane dislocases: a second chance for protein targeting by Dederer, Verena, Lemberg, Marius K.

“…Precise distribution of proteins is essential to sustain the viability of cells. A complex network of protein synthesis and targeting factors cooperate with…”
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Intramembrane proteolysis at a glance: from signalling to protein degradation by Kühnle, Nathalie, Dederer, Verena, Lemberg, Marius K

“…Over the last two decades, a group of unusual proteases, so-called intramembrane proteases, have become increasingly recognized for their unique ability to…”
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Sampling the membrane: function of rhomboid-family proteins by Lemberg, Marius K

“…Rhomboids constitute a conserved protein superfamily that specifically binds membrane proteins and directs them into various different cellular pathways…”
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Inactive rhomboid proteins: New mechanisms with implications in health and disease by Lemberg, Marius K., Adrain, Colin

“…Rhomboids, proteases containing an unusual membrane-integral serine protease active site, were first identified in Drosophila, where they fulfill an essential…”
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