Search Results - "Leman, Adam R"

Local and global functions of Timeless and Tipin in replication fork protection by Leman, Adam R., Noguchi, Eishi

“…The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course of every cell cycle. This accomplishment is remarkable…”
Get full text

Warm nights disrupt transcriptome rhythms in field-grown rice panicles by Desai, Jigar S., Lawas, Lovely Mae F., Valente, Ashlee M., Leman, Adam R., Grinevich, Dmitry O., Jagadish, S. V. Krishna, Doherty, Colleen J.

“…In rice, a small increase in nighttime temperature reduces grain yield and quality. How warm nighttime temperatures (WNT) produce these detrimental effects is…”
Get full text

Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion by Leman, Adam R, Noguchi, Chiaki, Lee, Candice Y, Noguchi, Eishi

“…The Timeless-Tipin protein complex has been reported to be important for replication checkpoint and normal DNA replication processes. However, the precise…”
Get full text

Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans by Kelliher, Christina M, Leman, Adam R, Sierra, Crystal S, Haase, Steven B

“…The pathogenic yeast Cryptococcus neoformans causes fungal meningitis in immune-compromised patients. Cell proliferation in the budding yeast form is required…”
Get full text

Linking chromosome duplication and segregation via sister chromatid cohesion by Leman, Adam R, Noguchi, Eishi

“…DNA replication during S phase generates two identical copies of each chromosome. Each chromosome is destined for a daughter cell, but each daughter must…”
Get more information

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres by Leman, Adam R., Dheekollu, Jayaraju, Deng, Zhong, Lee, Seung Woo, Das, Mukund M., Lieberman, Paul M., Noguchi, Eishi

“…A variety of telomere protection programs are utilized to preserve telomere structure. However, the complex nature of telomere maintenance remains elusive. The…”
Get full text

An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum by Smith, Lauren M, Motta, Francis C, Chopra, Garima, Moch, J Kathleen, Nerem, Robert R, Cummins, Bree, Roche, Kimberly E, Kelliher, Christina M, Leman, Adam R, Harer, John, Gedeon, Tomas, Waters, Norman C, Haase, Steven B

“…The blood stage of the infection of the malaria parasite exhibits a 48-hour developmental cycle that culminates in the synchronous release of parasites from…”
Get full text

A normalization method that controls for total RNA abundance affects the identification of differentially expressed genes, revealing bias toward morning‐expressed responses by Laosuntisuk, Kanjana, Vennapusa, Amaranatha, Somayanda, Impa M., Leman, Adam R., Jagadish, SV Krishna, Doherty, Colleen J.

“…SUMMARY RNA‐Sequencing is widely used to investigate changes in gene expression at the transcription level in plants. Most plant RNA‐Seq analysis pipelines…”
Get full text

Sequence Diversity in the Glycoprotein B Gene Complicates Real-Time PCR Assays for Detection and Quantification of Cytomegalovirus by Nye, Melinda B, Leman, Adam R, Meyer, Michelle E, Menegus, Marilyn A, Rothberg, Paul G

“…Real-time quantitative PCR systems (Q-PCR) for the rapid detection and quantification of microorganisms in clinical specimens employ oligodeoxyribonucleotide…”
Get full text

The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication by Leman, Adam R, Noguchi, Eishi

“…Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of…”
Get full text

The parasite intraerythrocytic cycle and human circadian cycle are coupled during malaria infection by Motta, Francis C, McGoff, Kevin, Moseley, Robert C, Cho, Chun-Yi, Kelliher, Christina M, Smith, Lauren M, Ortiz, Michael S, Leman, Adam R, Campione, Sophia A, Devos, Nicolas, Chaorattanakawee, Suwanna, Uthaimongkol, Nichaphat, Kuntawunginn, Worachet, Thongpiam, Chadin, Thamnurak, Chatchadaporn, Arsanok, Montri, Wojnarski, Mariusz, Vanchayangkul, Pattaraporn, Boonyalai, Nonlawat, Smith, Philip L, Spring, Michele D, Jongsakul, Krisada, Chuang, Ilin, Harer, John, Haase, Steven B

“…During infections with the malaria parasites , patients exhibit rhythmic fevers every 48 h. These fever cycles correspond with the time the parasites take to…”
Get full text

The Local Edge Machine: inference of dynamic models of gene regulation by McGoff, Kevin A, Guo, Xin, Deckard, Anastasia, Kelliher, Christina M, Leman, Adam R, Francey, Lauren J, Hogenesch, John B, Haase, Steven B, Harer, John L

“…We present a novel approach, the Local Edge Machine, for the inference of regulatory interactions directly from time-series gene expression data. We…”
Get full text

The double-bromodomain proteins Bdf1 and Bdf2 modulate chromatin structure to regulate S-phase stress response in Schizosaccharomyces pombe by Garabedian, Mikael V, Noguchi, Chiaki, Ziegler, Melissa A, Das, Mukund M, Singh, Tanu, Harper, Logan J, Leman, Adam R, Khair, Lyne, Moser, Bettina A, Nakamura, Toru M, Noguchi, Eishi

“…Bromodomain proteins bind acetylated histones to regulate transcription. Emerging evidence suggests that histone acetylation plays an important role in DNA…”
Get full text

Chromatin immunoprecipitation to investigate origin association of replication factors in mammalian cells by Leman, Adam R, Noguchi, Eishi

“…A variety of DNA-binding proteins regulate DNA transactions including DNA replication and DNA damage response. To initiate DNA replication in S phase of the…”
Get more information

Checkpoints couple transcription network oscillator dynamics to cell-cycle progression by Bristow, Sara L, Leman, Adam R, Simmons Kovacs, Laura A, Deckard, Anastasia, Harer, John, Haase, Steven B

“…The coupling of cyclin dependent kinases (CDKs) to an intrinsically oscillating network of transcription factors has been proposed to control progression…”
Get full text

Homogeneous PCR nucleobase quenching assays to detect four mutations that cause neuronal ceroid lipofuscinosis: T75P and R151X in CLN1, and IVS5-1G > C and R208X in CLN2 by Leman, Adam R., Polochock, Susan, Mole, Sara E., Pearce, David A., Rothberg, Paul G.

“…The neuronal ceroid lipofuscinoses (NCLs) are a family of autosomal recessive lysosomal storage diseases characterized by progressive epilepsy, dementia and…”
Get full text

Precision fermentation for food proteins: ingredient innovations, bioprocess considerations, and outlook — a mini-review by Eastham, J. Lucas, Leman, Adam R.

“…The growing demand for dietary protein presents challenges for environmentally sustainable food production within global limits. Precision fermentation (PF)…”
Get full text

Analyzing transcription dynamics during the budding yeast cell cycle by Leman, Adam R, Bristow, Sara L, Haase, Steven B

“…Assaying global cell cycle-regulated transcription in budding yeast involves extracting RNA from a synchronous population and proper normalization of detected…”
Get more information

Cell cycle-regulated transcription: effectively using a genomics toolbox by Bristow, Sara L, Leman, Adam R, Haase, Steven B

“…The cell cycle comprises a series of temporally ordered events that occur sequentially, including DNA replication, centrosome duplication, mitosis, and…”
Get more information

Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype by Kwon, Jennifer M., Rothberg, Paul G., Leman, Adam R., Weimer, Jill M., Mink, Jonathan W., Pearce, David A.

“…Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), or Batten disease, is a childhood neurodegenerative disease that is characterized clinically by progressive…”
Get full text