Prevalence of grey matter pathology in early multiple sclerosis assessed by magnetization transfer ratio imaging

The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 9; p. e24969
Main Authors:	Crespy, Lydie, Zaaraoui, Wafaa, Lemaire, Mathias, Rico, Audrey, Faivre, Anthony, Reuter, Françoise, Malikova, Irina, Confort-Gouny, Sylviane, Cozzone, Patrick J, Pelletier, Jean, Ranjeva, Jean-Philippe, Audoin, Bertrand
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15-09-2011 Public Library of Science (PLoS)
Subjects:	Abnormalities Adolescent Adult Brain - pathology Brain Mapping Case-Control Studies Cerebellum Cortex (frontal) Cortex (occipital) Cortex (parietal) Cortex (temporal) Diagnostic Imaging Disability Disease Progression Humans Image Processing, Computer-Assisted Lesions Magnetic fields Magnetic Resonance Imaging Magnetization Medical research Medicine Middle Aged Multiple sclerosis Multiple Sclerosis - pathology Nervous system Neuroimaging Neurosciences NMR Nuclear magnetic resonance Occipital lobe Pathology Patients Population (statistical) Regression analysis Spinal cord Statistical analysis Studies Substantia alba Substantia grisea Temporal cortex Young Adult
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Summary:	The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four healthy controls constituted the normative population. An optimized statistical mapping analysis was performed to compare each subject's GM Magnetization Transfer Ratio (MTR) imaging maps with those of the whole group of controls. The statistical threshold of significant GM MTR decrease was determined as the maximum p value (p<0.05 FDR) for which no significant cluster survived when comparing each control to the whole control population. Using this threshold, 51% of patients showed GM abnormalities compared to controls. Locally, 37% of patients presented abnormalities inside the limbic cortex, 34% in the temporal cortex, 32% in the deep grey matter, 30% in the cerebellum, 30% in the frontal cortex, 26% in the occipital cortex and 19% in the parietal cortex. Stepwise regression analysis evidenced significant association (p = 0.002) between EDSS and both GM pathology (p = 0.028) and T2 white matter lesions load (p = 0.019). In the present study, we evidenced that individual analysis of GM MTR map allowed demonstrating that GM pathology is highly heterogeneous across patients at the early stage of MS and partly underlies irreversible disability.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: WZ BA JP JPR PC SC. Performed the experiments: LC IM AF FR AR. Analyzed the data: LC ML WZ. Contributed reagents/materials/analysis tools: ML JPR. Wrote the paper: BA LC WZ.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0024969