Search Results - "Leleux, Jardin"

The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma by Pradhan, Pallab, Qin, Hong, Leleux, Jardin A, Gwak, Dongho, Sakamaki, Ippei, Kwak, Larry W, Roy, Krishnendu

“…Abstract Success of an immunotherapy for cancer often depends on the critical balance of T helper 1 (Th1) and T helper 2 (Th2) responses driven by antigen…”
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Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory by Leleux, Jardin A, Albershardt, Tina C, Reeves, Rebecca, James, Reice, Krull, Jordan, Parsons, Andrea J, Ter Meulen, Jan, Berglund, Peter

“…Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two…”
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Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses by Leleux, Jardin A., Pradhan, Pallab, Roy, Krishnendu

“…It is currently unknown whether and how mammalian pathogen recognition receptors (PRRs) respond to biophysical patterns of pathogen-associated molecular danger…”
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ZVex™, a dendritic-cell-tropic lentivector, primes protective antitumor T cell responses that are significantly boosted using heterologous vaccine modalities by Leleux, Jardin A., Albershardt, Tina C., Parsons, Andrea J., ter Meulen, Jan, Berglund, Peter

“…Therapeutic cancer vaccines must induce high levels of tumor-specific cytotoxic CD8 T cells to be effective. We show here that tumor-antigen specific effector…”
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Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors by Albershardt, Tina C., Leleux, Jardin, Parsons, Andrea J., Krull, Jordan E., Berglund, Peter, ter Meulen, Jan

“…Effective T cell-based immunotherapy of solid malignancies requires intratumoral activity of cytotoxic T cells and induction of protective immune memory. A…”
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Effects of shear stress on germ lineage specification of embryonic stem cells by Wolfe, Russell P, Leleux, Jardin, Nerem, Robert M, Ahsan, Tabassum

“…Mechanobiology to date has focused on differentiated cells or progenitors, yet the effects of mechanical forces on early differentiation of pluripotent stem…”
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Surface-Presentation of CpG and Protein–Antigen on Pathogen-Like Polymer Particles Generate Strong Prophylactic and Therapeutic Antitumor Protection by Dawson, Eileen, Leleux, Jardin A, Pradhan, Pallab, Roy, Krishnendu

“…Despite significant efforts, development of clinically relevant prophylactic and therapeutic cancer vaccines has proven challenging. Cancer-associated…”
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Micro and Nanoparticle-Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective by Leleux, Jardin, Roy, Krishnendu

“…The development and widespread application of vaccines has been one of the most significant achievements of modern medicine. Vaccines have not only been…”
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Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy by Leleux, Jardin, Atalis, Alexandra, Roy, Krishnendu

“…While successful vaccines have been developed against many pathogens, there are still many diseases and pathogenic infections that are highly evasive to…”
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Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist by Leleux, Jardin A, Albershardt, Tina C, Reeves, Rebecca, James, Reice, Krull, Jordan, Parsons, Andrea J, ter Meulen, Jan, Berglund, Peter

“…Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two…”
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Recent advancements in mechanical reduction methods: particulate systems by Leleux, Jardin, Williams, Robert O.

“…Abstract The screening of new active pharmaceutical ingredients (APIs) has become more streamlined and as a result the number of new drugs in the pipeline is…”
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Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) controls immune synapse stability in human T cells by Janssen, Willemijn J.M., Grobarova, Valeria, Leleux, Jardin, Jongeneel, Lieneke, van Gijn, Marielle, van Montfrans, Joris M., Boes, Marianne

“…Proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1) is a cytosolic adaptor protein involved with T-cell activation, differentiation, and…”
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Abstract 5673: Large established B16 tumors in mice are eradicated by ZVex® (dendritic cell-targeting lentiviral vector) and G100 (TLR4 agonist) combination immunotherapy through increasing tumor-infiltrating effector T cells and inducing antigen spreading by Albershardt, Tina C., Parsons, Andrea J., Leleux, Jardin, Berglund, Peter, Meulen, Jan ter

“…Abstract INTRODUCTION: Effective immunotherapy requires the presence of effector T cells penetrating the tumor. ZVex is a hybrid lentiviral vector platform…”
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A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo by Roh, Kyung-Ho, Song, Hannah W., Pradhan, Pallab, Bai, Kevin, Bohannon, Caitlin D., Dale, Gordon, Leleux, Jardin, Jacob, Joshy, Roy, Krishnendu

“…B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory…”
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A simple, clinically relevant therapeutic vaccine shows long-term protection in an aggressive, delayed-treatment B lymphoma model by Pradhan, Pallab, Leleux, Jardin, Liu, Jiaying, Roy, Krishnendu

“…Despite initial remission after successful treatments, B lymphoma patients often encounter relapses and resistance causing high mortality. Thus, there is a…”
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Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors by Albershardt, Tina C, Leleux, Jardin, Parsons, Andrea J, Krull, Jordan E, Berglund, Peter, Ter Meulen, Jan

“…Effective T cell-based immunotherapy of solid malignancies requires intratumoral activity of cytotoxic T cells and induction of protective immune memory. A…”
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Effects of shear stress on germ lineage specification of embryonic stem cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/c2ib20040f by Wolfe, Russell P, Leleux, Jardin, Nerem, Robert M, Ahsan, Tabassum

“…Mechanobiology to date has focused on differentiated cells or progenitors, yet the effects of mechanical forces on early differentiation of pluripotent stem…”
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