Search Results - "Lekstrom, Kristen"

Comparative systeomics to elucidate physiological differences between CHO and SP2/0 cell lines by Demirhan, Deniz, Kumar, Amit, Zhu, Jie, Poulsen, Pi Camilla, Majewska, Natalia I., Sebastian, Yinong, Chaerkady, Raghothama, Yu, Wen, Zhu, Wei, Zhuang, Li, Shah, Punit, Lekstrom, Kristen, Cole, Robert N., Zhang, Hui, Betenbaugh, Michael J., Bowen, Michael A.

“…Omics-based tools were coupled with bioinformatics for a systeomics analysis of two biopharma cell types: Chinese hamster ovary (M-CHO and CHO-K1) and SP2/0…”
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Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration by Kwon, Jaeyul, Wang, Aibing, Burke, Devin J., Boudreau, Howard E., Lekstrom, Kristen J., Korzeniowska, Agnieszka, Sugamata, Ryuichi, Kim, Yong-Soo, Yi, Liang, Ersoy, Ilker, Jaeger, Stefan, Palaniappan, Kannappan, Ambruso, Daniel R., Jackson, Sharon H., Leto, Thomas L.

“…Nox1 is an abundant source of reactive oxygen species (ROS) in colon epithelium recently shown to function in wound healing and epithelial homeostasis. We…”
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Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells by Geiszt, Miklós, Lekstrom, Kristen, Witta, Jassir, Leto, Thomas L.

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Multivalent scaffold proteins as superagonists of TRAIL receptor 2-induced apoptosis by Swers, Jeffery S, Grinberg, Luba, Wang, Lin, Feng, Hui, Lekstrom, Kristen, Carrasco, Rosa, Xiao, Zhan, Inigo, Ivan, Leow, Ching Ching, Wu, Herren, Tice, David A, Baca, Manuel

“…Activation of TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) can induce apoptosis in a variety of human cancer cell lines and xenografts, while…”
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Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense by Geiszt, Miklós, Witta, Jassir, Baff, Judit, Lekstrom, Kristen, Leto, Thomas L.

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The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA by Peng, Li, Oberst, Michael D, Huang, Jiaqi, Brohawn, Philip, Morehouse, Chris, Lekstrom, Kristen, Baeuerle, Patrick A, Wu, Herren, Yao, Yihong, Coats, Steven R, Dall'Acqua, William, Damschroder, Melissa, Hammond, Scott A

“…MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing…”
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Enhancing IgG distribution to lung mucosal tissue improves protective effect of anti-Pseudomonas aeruginosa antibodies by Borrok, M Jack, DiGiandomenico, Antonio, Beyaz, Nurten, Marchetti, Gabriela M, Barnes, Arnita S, Lekstrom, Kristen J, Phipps, Sandrina S, McCarthy, Michael P, Wu, Herren, Dall'Acqua, William F, Tsui, Ping, Gupta, Ruchi

“…IgG antibodies are abundantly present in the vasculature but to a much lesser extent in mucosal tissues. This contrasts with antibodies of the IgA and IgM…”
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Subcellular localization and function of alternatively spliced Noxo1 isoforms by Ueyama, Takehiko, Lekstrom, Kristen, Tsujibe, Satoshi, Saito, Naoaki, Leto, Thomas L.

“…Nox organizer 1 (Noxo1), a p47 phox homolog, is produced as four isoforms with unique N-terminal PX domains derived by alternative mRNA splicing. We compared…”
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Epstein-Barr Virus BARF1 Protein Is Dispensable for B-Cell Transformation and Inhibits Alpha Interferon Secretion from Mononuclear Cells by Cohen, J I, Lekstrom, K

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Analysis of mRNA Transcripts from the NAD(P)H Oxidase 1 (Nox1) Gene by Geiszt, Miklós, Lekstrom, Kristen, Leto, Thomas L.

“…Recent reports indicate that NAD(P)H oxidase 1 (Nox1) mRNA undergoes alternative splicing, producing a short transcript (NOH-1S) encoding a novel H+ channel…”
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The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated Elongation Factor 2 gene by HOGAN, K. T, EISINGER, D. P, CUPP, S. B, LEKSTROM, K. J, DEACON, D. D, SHABANOWITZ, J, HUNT, D. F, ENGELHARD, V. H, SLINGLUFF, C. L, ROSS, M. M

“…The identification of naturally processed tumor peptides that can stimulate a tumor-specific, CTL response is crucial to the development of a vaccine-based,…”
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Proteins Homologous to p47phox and p67phox Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells by Geiszt, Miklós, Lekstrom, Kristen, Witta, Jassir, Leto, Thomas L.

“…Superoxide production by phagocytes involves activation of a multi-component NADPH oxidase. Recently, several homologues of the catalytic component of the…”
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CD47 limits antibody dependent phagocytosis against non-malignant B cells by Gallagher, Sandra, Turman, Sean, Lekstrom, Kristen, Wilson, Susan, Herbst, Ronald, Wang, Yue

“…•Plasma cells have highest expression of CD47 among murine B cell subsets.•CD47 limits anti-CD19 dependent phagocytosis against non-malignant B cells.•Blocking…”
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Statistical Models for the Analysis of Isobaric Tags Multiplexed Quantitative Proteomics by D’Angelo, Gina, Chaerkady, Raghothama, Yu, Wen, Hizal, Deniz Baycin, Hess, Sonja, Zhao, Wei, Lekstrom, Kristen, Guo, Xiang, White, Wendy I, Roskos, Lorin, Bowen, Michael A, Yang, Harry

“…Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry-based labeling proteomic…”
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Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense by Geiszt, Miklós, Witta, Jassir, Baff, Judit, Lekstrom, Kristen, Leto, Thomas L.

“…ABSTRACT Lactoperoxidase (LPO) is an enzyme with antimicrobial properties present in saliva, milk, tears, and airway secretions. Although the formation of…”
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The Pseudomonas Toxin Pyocyanin Inhibits the Dual Oxidase-Based Antimicrobial System as It Imposes Oxidative Stress on Airway Epithelial Cells by Rada, Balazs, Lekstrom, Kristen, Damian, Sorin, Dupuy, Corinne, Leto, Thomas L

“…The dual oxidase-thiocyanate-lactoperoxidase (Duox/SCN(-)/LPO) system generates the microbicidal oxidant hypothiocyanite in the airway surface liquid by using…”
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Abstract 1166: ASCT2: A novel metabolic target for cancer therapy by Pore, Nabendu, King, Wanda, Lekstrom, Kristen, Wilson, Susan, Hollingsworth, Robert, Tice, David A., Michelotti, Emil

“…Abstract Uncontrolled proliferation of cancer cells is often fueled by the deregulation of various cellular signaling pathways. Such deregulation also…”
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Peroxiredoxin 6 (Prdx6) Supports NADPH Oxidase1 (Nox1)-Based Reactive Oxygen Species Generation and Cell Migration by Leto, Thomas, Wang, Aibing, Burke, Devin, Boudreau, Howard, Lekstrom, Kristen, Korzeniowska, Agnieszka, Sugamata, Ryuichi, Esroy, lker, Jaeger, Stefan, Palaniappan, Kannappan, Ambruso, Daniel R., Jackson, Sharon H., Kwon, Jaeyul

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254 - Peroxiredoxin 6 (Prdx6) Supports NADPH Oxidase1 (Nox1)-Based Reactive Oxygen Species Generation and Cell Migration by Leto, Thomas, Wang, Aibing, Burke, Devin, Boudreau, Howard, Lekstrom, Kristen, Korzeniowska, Agnieszka, Sugamata, Ryuichi, Esroy, lker, Jaeger, Stefan, Palaniappan, Kannappan, Ambruso, Daniel R., Jackson, Sharon H., Kwon, Jaeyul

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Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant by Geiszt, Miklós, Lekstrom, Kristen, Leto, Thomas L

“…Recent reports indicate that NAD(P)H oxidase 1 (Nox1) mRNA undergoes alternative splicing, producing a short transcript (NOH-1S) encoding a novel H+ channel…”
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