Search Results - "Lekieffre, D"

Increased neurosteroids synthesis after brain and spinal cord injury in rats by di Michele, F., Lekieffre, D., Pasini, A., Bernardi, G., Benavides, J., Romeo, E.

“…We studied the effect of brain and spinal cord injury induced by fluid-percussion on the local synthesis of neurosteroids as measured by a…”
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Reduced postischemic expression of a glial glutamate transporter, GLT1, in the rat hippocampus by TORP, R, LEKIEFFRE, D, LEVY, L. M, HAUG, F. M, DANBOLT, N. C, MELDRUM, B. S, OTTERSEN, O. P

“…Perturbations of the synaptic handling of glutamate have been implicated in the pathogenesis of brain damage after transient ischemia. Notably, the ischemic…”
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The pyrimidine-derivative, BW1003C87, protects CA1 and striatal neurons following transient severe forebrain ischaemia in rats. A microdialysis and histological study by Lekieffre, D, Meldrum, B S

“…The four vessel occlusion model of severe transient global ischaemia in Wistar rats has been used to study changes in the extracellular concentration of amino…”
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Concomitant increases in the extracellular concentrations of excitatory and inhibitory amino acids in the rat hippocampus during forebrain ischemia by Lekieffre, D, Callebert, J, Plotkine, M, Boulu, R G

“…The extracellular concentrations of aspartate, glutamate, glutamine, taurine and gamma-aminobutyric acid in the hippocampus were determined during and after…”
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Effects of an A1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia by Héron, A, Lekieffre, D, Le Peillet, E, Lasbennes, F, Seylaz, J, Plotkine, M, Boulu, R G

“…Untreated rats and rats given the A1 receptor adenosine agonist, R-phenylisopropyladenosine (R-PIA), were subjected to four vessel ischemia. The effect of…”
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Effect of the non-NMDA receptor antagonist GYKI 52466 on the microdialysate and tissue concentrations of amino acids following transient forebrain ischaemia by Arvin, B, Lekieffre, D, Graham, J L, Moncada, C, Chapman, A G, Meldrum, B S

“…The effect of the non-N-methyl-D-aspartate (non-NMDA) receptor antagonist 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride…”
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Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia by Lekieffre, D, Ghribi, O, Callebert, J, Allix, M, Plotkine, M, Boulu, R G

“…We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and…”
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Kynurenic acid antagonizes hippocampal quinolinic acid neurotoxicity: behavioral and histological evaluation by Lekieffre, D, Plotkine, M, Allix, M, Boulu, R G

“…In the present study, we evaluate the ability of kynurenic acid to protect hippocampal neurons from the neurotoxicity of the N-methyl-D-aspartate (NMDA)…”
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Enhancement of endogenous excitatory amino acids by theophylline does not modify the behavioral and histological consequences of forebrain ischemia by Lekieffre, D, Callebert, J, Plotkine, M, Allix, M, Boulu, R G

“…The neuroprotective role of endogenous adenosine during forebrain ischemia elicited by 4-vessel occlusion in rats was assessed using the adenosine antagonist,…”
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Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions by Moncada, C, Lekieffre, D, Arvin, B, Meldrum, B

“…We assessed the effect of NG-Nitro-L-arginine methylester (L-NAME), an inhibitor of nitric oxide synthase, on the hippocampal lesions induced either by the…”
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Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model by Lekieffre, Delphine, Benavides, Jesus, Scatton, Bernard, Nowicki, Jean-Pierre

“…In the present study, we have assessed the efficacy of eliprodil, a neuroprotective agent which blocks both the modulatory polyamine site of the NMDA receptor…”
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Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia in the rat by Smith, S E, Lekieffre, D, Sowinski, P, Meldrum, B S

“…BW619C89 (4-amino-2-(4-methylpiperazin-l-yl)-5-(2,3,5-trichlorophenyl) pyrimidine) was evaluated for cerebroprotection after focal or global ischaemia…”
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Biphasic transforming growth factor-beta production flanking the pro-inflammatory cytokine response in cerebral trauma by Rimaniol, A C, Lekieffre, D, Serrano, A, Masson, A, Benavides, J, Zavala, F

“…We determined the time-course of the production of transforming growth factor-beta (TGF-beta) after fluid-percussion injury using a bioassay. Biophasic…”
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