Search Results - "Leivers, Anna"

Discovery of Selective Small Molecule Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα) Inhibitors as Anti Hepatitis C (HCV) Agents by Leivers, Anna L., Tallant, Matthew, Shotwell, J. Brad, Dickerson, Scott, Leivers, Martin R., McDonald, Octerloney B., Gobel, Jeff, Creech, Katrina L., Strum, Susan L., Mathis, Amanda, Rogers, Sabrinia, Moore, Chris B., Botyanszki, Janos

“…Hepatitis C virus (HCV) assembles many host cellular proteins into unique membranous replication structures as a prerequisite for viral replication, and…”
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Phenoxide leaving group SNAr strategy for the facile preparation of 7-amino-3-aryl pyrazolo[1,5-a]pyrimidines from a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate by Catalano, John G., Gaitonde, Vishwanath, Beesu, Mallesh, Leivers, Anna L., Shotwell, J. Brad

“…[Display omitted] We have discovered a 3-bromo-7-phenoxypyrazolo[1,5-a]pyrimidine intermediate that allows for the direct sequential funtionalization of the…”
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Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase by Maynard, Andrew, Crosby, Renae M., Ellis, Byron, Hamatake, Robert, Hong, Zhi, Johns, Brian A., Kahler, Kirsten M., Koble, Cecilia, Leivers, Anna, Leivers, Martin R., Mathis, Amanda, Peat, Andrew J., Pouliot, Jeffrey J., Roberts, Christopher D., Samano, Vicente, Schmidt, Rachel M., Smith, Gary K., Spaltenstein, Andrew, Stewart, Eugene L., Thommes, Pia, Turner, Elizabeth M., Voitenleitner, Christian, Walker, Jill T., Waitt, Greg, Weatherhead, Jason, Weaver, Kurt, Williams, Shawn, Wright, Lois, Xiong, Zhiping Z., Haigh, David, Shotwell, J. Brad

“…A boronic acid moiety was found to be a critical pharmacophore for enhanced in vitro potency against wild-type hepatitis C replicons and known clinical…”
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