Epidemiology, Outcomes, and Associated Factors of Coronavirus Disease 2019 (COVID-19) Reverse Transcriptase Polymerase Chain Reaction-Confirmed Cases in the San Pedro Sula Metropolitan Area, Honduras

Epidemiology, Outcomes, and Associated Factors of Coronavirus Disease 2019 (COVID-19) Reverse Transcriptase Polymerase Chain Reaction-Confirmed Cases in the San Pedro Sula Metropolitan Area, Honduras

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused substantial morbidity and mortality worldwide. Few reports exist in Latin America, a current epicenter of transmission. Here, we aim to describe the epidemiology and outcomes associated with coronavirus disease 2019...

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Published in:Clinical infectious diseases Vol. 72; no. 10; pp. e476 - e483
Main Authors: Zuniga-Moya, Julio C, Norwood, Dalton Argean, Romero Reyes, Luis Enrique, Barrueto Saavedra, Emilio, Diaz, Roxana, Fajardo, Wendy Carolina, Pineda, Allan, Torres, Diana, Barahona, Rodolfo, Leiva, Said Omar, Hernandez, Pastora X, Silva, Hector, Leiva, Carlos Raul, Estrada, Lourdes, Barahona-Campos, Alma, Gordon, Aubree
Format: Journal Article
Language:English
Published: United States Oxford University Press 18-05-2021
Subjects:
Adult
Aged
COVID-19
Honduras - epidemiology
Hospitalization
Humans
Male
Middle Aged
Online Only
Pandemics
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Young Adult
Honduras
COVID-19
epidemiology
SARS-CoV-2
associated factors
Latin America
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Summary:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused substantial morbidity and mortality worldwide. Few reports exist in Latin America, a current epicenter of transmission. Here, we aim to describe the epidemiology and outcomes associated with coronavirus disease 2019 (COVID-19) in Honduras. Baseline clinical and epidemiological information of SARS-CoV-2 reverse transcriptase polymerase chain reaction-confirmed cases detected between 17 March-4 May in the San Pedro Sula Metropolitan area was collected; for hospitalized cases, clinical data were abstracted. Logistic regression models were fit to determine the factors associated with hospitalization. We identified 877 COVID-19 cases, of which 25% (n = 220) were hospitalized. The 19-44-year age group (57.8%) and males (61.3%) were predominant in overall COVID-19 cases. Of the cases, 34% (n = 299) had at least 1 preexisting medical condition. Individuals aged 45-69 years (adjusted odds ratio [aOR] = 4.05; 95% confidence interval [CI], 2.85-5.76) or ≥70 years (aOR = 9.12; 95% CI, 5.24-15.86), of male sex (aOR = 1.72; 95% CI, 1.21-2.44), and those with a preexisting condition (aOR = 2.12; 95% CI, 1.43-3.14) had higher odds of hospitalization. Of inpatients, 50% were hospitalized more than 7 days. The median length of hospitalization was 13 days (interquartile range [IQR], 8-29) among individuals aged 19-44 years, and 17 days (IQR, 11-24.6) among those aged 45-69. Of the fatal cases, 42% occurred among adults under 60 years old. Our findings show that a high proportion of COVID-19 cases in Honduras occurred among younger adults, who also constituted a significant proportion of severe and fatal cases. Preexisting conditions were associated with severe outcomes independently from age and were highly prevalent in Honduran COVID-19 cases.
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ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciaa1188