Search Results - "Leitner, Wolfgang W."

Review: Current trends, challenges, and success stories in adjuvant research by Singleton, Kentner L, Joffe, Ari, Leitner, Wolfgang W

“…Vaccine adjuvant research is being fueled and driven by progress in the field of innate immunity that has significantly advanced in the past two decades with…”
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Inhibitory effects of B cells on antitumor immunity by INOUE, Satoshi, LEITNER, Wolfgang W, GOLDING, Basil, SCOTT, Dorothy

“…B-cell functions in antitumor immunity are not well understood. In this study, we evaluated the role of B cells in the development of antitumor immunity using…”
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Comprehensive immunoprofiling and systematic adjuvant comparisons for identifying suitable vaccine: Adjuvant pairings by Vázquez-Maldonado, Nancy, Kelly, Halonna R., Leitner, Wolfgang W.

“…Adjuvants are critical components of vaccines that enhance the host immune response to the vaccine antigen, however, only a small number of adjuvants are used…”
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Immune mechanisms of protection against Mycobacterium tuberculosis -centers by Dang, Que, Eichelberg, Katrin, Vázquez-Maldonado, Nancy, Boggiano, César, Leitner, Wolfgang W, Ramachandra, Lakshmi, Deckhut-Augustine, Alison, Read, Sarah W

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Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions by Nagao, Keisuke, Ginhoux, Florent, Leitner, Wolfgang W, Motegi, Sei-Ichiro, Bennett, Clare L, Clausen, Björn E, Merad, Miriam, Udey, Mark C

“…A new langerin⁺ DC subset has recently been identified in murine dermis (langerin⁺ dDC), but the lineage and functional relationships between these cells and…”
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Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report by Knisely, Jane M., Buyon, Lucas E., Mandt, Rebecca, Farkas, Rebecca, Balasingam, Shobana, Bok, Karin, Buchholz, Ursula J., D’Souza, M. Patricia, Gordon, Jennifer L., King, Deborah F. L., Le, Tung T., Leitner, Wolfgang W., Seder, Robert A., Togias, Alkis, Tollefsen, Stig, Vaughn, David W., Wolfe, Daniel N., Taylor, Kimberly L., Fauci, Anthony S.

“…On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The…”
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Arthropod Vectors and Disease Transmission: Translational Aspects by Leitner, Wolfgang W, Wali, Tonu, Kincaid, Randall, Costero-Saint Denis, Adriana

“…  Research on sand fly saliva as a vaccine against Leishmania parasites has yielded valuable insights into the mechanism of protection mediated by vector…”
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Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis by Motegi, Sei-ichiro, Leitner, Wolfgang W, Lu, Michael, Tada, Yayoi, Sárdy, Miklós, Wu, Chuanjin, Chavakis, Triantafyllos, Udey, Mark C

“…OBJECTIVE—MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial…”
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Role of Opsonophagocytosis in Immune Protection against Malaria by Leitner, Wolfgang W., Haraway, Megan, Pierson, Tony, Bergmann-Leitner, Elke S.

“…The quest for immune correlates of protection continues to slow vaccine development. To date, only vaccine-induced antibodies have been confirmed as direct…”
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Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity by Chaudhury, Sidhartha, Duncan, Elizabeth H., Atre, Tanmaya, Dutta, Sheetij, Spring, Michele D., Leitner, Wolfgang W., Bergmann-Leitner, Elke S.

“…Adjuvants produce complex, but often subtle, effects on vaccine-induced immune responses that, nonetheless, play a critical role in vaccine efficacy. In-depth…”
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Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators by Bergmann-Leitner, Elke S, Leitner, Wolfgang W

“…The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. From here, the…”
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Meeting Report: Translational Considerations of Novel Vector Management Approaches by Costero-Saint Denis, Adriana, Leitner, Wolfgang W, Wali, Tonu, James, Stephanie

“…Are there conditions under which the novel strategy has a competitive advantage over other currently used disease control strategies? A target product profile…”
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MFG-E8/Lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis by NEUTZNER, Melanie, LOPEZ, Theresa, XU FENG, BERGNLANN-LEITNER, Elke S, LEITNER, Wolfgang W, UDEY, Mark C

“…The relevance of angiogenesis in tumor biology and as a therapeutic target is well established. MFG-E8 (also termed lactadherin) and developmental endothelial…”
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Tiny but mighty: small molecules as vaccine adjuvants by Joffe, Ari, Vázquez-Maldonado, Nancy, Singleton, Kentner L., Leitner, Wolfgang W.

“…Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary…”
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Biological functions of DEAD/DEAH-box RNA helicases in health and disease by Andrisani, Ourania, Liu, Qian, Kehn, Patricia, Leitner, Wolfgang W., Moon, Kyung, Vazquez-Maldonado, Nancy, Fingerman, Ian, Gale, Michael

“…On 15–16 November 2021, the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI) and the National Heart, Lung,…”
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Is arthropod saliva the achilles' heel of vector-borne diseases? by Leitner, Wolfgang W, Wali, Tonu, Costero-Saint Denis, Adriana

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Comparison of Plasmodium berghei challenge models for the evaluation of pre-erythrocytic malaria vaccines and their effect on perceived vaccine efficacy by Leitner, Wolfgang W, Bergmann-Leitner, Elke S, Angov, Evelina

“…The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of…”
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Cancer therapy using a self-replicating RNA vaccine by Restifo, Nicholas P, Ying, Han, Zaks, Tal Z, Wang, Rong-Fu, Irvine, Kari R, Kammula, Udai S, Marincola, Francesco M, Leitner, Wolfgang W

“…'Naked' nucleic acid vaccines are potentially useful candidates for the treatment of patients with cancer, but their clinical efficacy has yet to be…”
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Polymeric Structure and Host Toll-like Receptor 4 Dictate Immunogenicity of NY-ESO-1 Antigen in Vivo by Liu, Yanan, Tian, Xiaoli, Leitner, Wolfgang W., Aldridge, Michael E., Zheng, Junying, Yu, Zhiya, Restifo, Nicholas P., Weiss, Richard, Scheiblhofer, Sandra, Xie, Chong, Sun, Ren, Cheng, Genhong, Zeng, Gang

“…In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms…”
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Precision adjuvants for pediatric vaccines by Singh, Anjali, Boggiano, César, Yin, Dwight E, Polakowski, Laura, Majji, Sai P, Leitner, Wolfgang W, Levy, Ofer, De Paris, Kristina

“…Elucidating optimal vaccine adjuvants for harnessing age-specific immune pathways to enhance magnitude, breadth, and durability of immunogenicity remains a key…”
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