Search Results - "Leitner, Wolfgang"

Review: Current trends, challenges, and success stories in adjuvant research by Singleton, Kentner L, Joffe, Ari, Leitner, Wolfgang W

“…Vaccine adjuvant research is being fueled and driven by progress in the field of innate immunity that has significantly advanced in the past two decades with…”
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Tiny but mighty: small molecules as vaccine adjuvants by Joffe, Ari, Vázquez-Maldonado, Nancy, Singleton, Kentner L., Leitner, Wolfgang W.

“…Screening small molecule (SM) libraries now replaces traditional methods for vaccine adjuvant discovery. A study by Soni et al. highlights the use of primary…”
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Biological functions of DEAD/DEAH-box RNA helicases in health and disease by Andrisani, Ourania, Liu, Qian, Kehn, Patricia, Leitner, Wolfgang W., Moon, Kyung, Vazquez-Maldonado, Nancy, Fingerman, Ian, Gale, Michael

“…On 15–16 November 2021, the National Institute of Allergy and Infectious Diseases (NIAID), the National Cancer Institute (NCI) and the National Heart, Lung,…”
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Inhibitory effects of B cells on antitumor immunity by INOUE, Satoshi, LEITNER, Wolfgang W, GOLDING, Basil, SCOTT, Dorothy

“…B-cell functions in antitumor immunity are not well understood. In this study, we evaluated the role of B cells in the development of antitumor immunity using…”
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Adjuvants in the Driver's Seat: How Magnitude, Type, Fine Specificity and Longevity of Immune Responses Are Driven by Distinct Classes of Immune Potentiators by Bergmann-Leitner, Elke S, Leitner, Wolfgang W

“…The mechanism by which vaccine adjuvants enhance immune responses has historically been considered to be the creation of an antigen depot. From here, the…”
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Comprehensive immunoprofiling and systematic adjuvant comparisons for identifying suitable vaccine: Adjuvant pairings by Vázquez-Maldonado, Nancy, Kelly, Halonna R., Leitner, Wolfgang W.

“…Adjuvants are critical components of vaccines that enhance the host immune response to the vaccine antigen, however, only a small number of adjuvants are used…”
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Precision adjuvants for pediatric vaccines by Singh, Anjali, Boggiano, César, Yin, Dwight E, Polakowski, Laura, Majji, Sai P, Leitner, Wolfgang W, Levy, Ofer, De Paris, Kristina

“…Elucidating optimal vaccine adjuvants for harnessing age-specific immune pathways to enhance magnitude, breadth, and durability of immunogenicity remains a key…”
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Arthropod Vectors and Disease Transmission: Translational Aspects by Leitner, Wolfgang W, Wali, Tonu, Kincaid, Randall, Costero-Saint Denis, Adriana

“…  Research on sand fly saliva as a vaccine against Leishmania parasites has yielded valuable insights into the mechanism of protection mediated by vector…”
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Immune mechanisms of protection against Mycobacterium tuberculosis -centers by Dang, Que, Eichelberg, Katrin, Vázquez-Maldonado, Nancy, Boggiano, César, Leitner, Wolfgang W, Ramachandra, Lakshmi, Deckhut-Augustine, Alison, Read, Sarah W

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Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions by Nagao, Keisuke, Ginhoux, Florent, Leitner, Wolfgang W, Motegi, Sei-Ichiro, Bennett, Clare L, Clausen, Björn E, Merad, Miriam, Udey, Mark C

“…A new langerin⁺ DC subset has recently been identified in murine dermis (langerin⁺ dDC), but the lineage and functional relationships between these cells and…”
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Mucosal vaccines for SARS-CoV-2: scientific gaps and opportunities—workshop report by Knisely, Jane M., Buyon, Lucas E., Mandt, Rebecca, Farkas, Rebecca, Balasingam, Shobana, Bok, Karin, Buchholz, Ursula J., D’Souza, M. Patricia, Gordon, Jennifer L., King, Deborah F. L., Le, Tung T., Leitner, Wolfgang W., Seder, Robert A., Togias, Alkis, Tollefsen, Stig, Vaughn, David W., Wolfe, Daniel N., Taylor, Kimberly L., Fauci, Anthony S.

“…On November 7th and 8th, 2022, The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), The…”
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Optimizing the Immunogenicity of HIV Vaccines by Adjuvants – NIAID Workshop Report by Singh, Anjali, Boggiano, César, Eller, Michael A., Maciel, Milton, Marovich, Mary A., Mehra, Vijay L., Mo, Annie X., Singleton, Kentner L., Leitner, Wolfgang W.

“…•Many novel adjuvants are available for rational selection with HIV vaccines.•Inducing protective and durable immunity to HIV presents unique…”
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Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks? by Prasanna, Pataje G., Woloschak, Gayle E., DiCarlo, Andrea L., Buchsbaum, Jeffrey C., Schaue, Dörthe, Chakravarti, Arnab, Cucinotta, Francis A., Formenti, Silvia C., Guha, Chandan, Hu, Dale J., Khan, Mohammad K., Kirsch, David G., Krishnan, Sunil, Leitner, Wolfgang W., Marples, Brian, McBride, William, Mehta, Minesh P., Rafii, Shahin, Sharon, Elad, Sullivan, Julie M., Weichselbaum, Ralph R., Ahmed, Mansoor M., Vikram, Bhadrasain, Coleman, C. Norman, Held, Kathryn D.

“…The limited impact of treatments for COVID-19 has stimulated several phase 1 clinical trials of whole-lung low-dose radiation therapy (LDRT; 0.3–1.5 Gy) that…”
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NCI Resources for Cancer Immunoprevention Research by Sei, Shizuko, Srivastava, Sudhir, Kelly, Halonna R, Miller, Mark Steven, Leitner, Wolfgang W, Shoemaker, Robert H, Szabo, Eva, Castle, Philip E

“…Cancer prevention and early detection, the first two of the eight primary goals of the National Cancer Plan released in April 2023, are at the forefront of the…”
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Pericyte-Derived MFG-E8 Regulates Pathologic Angiogenesis by Motegi, Sei-ichiro, Leitner, Wolfgang W, Lu, Michael, Tada, Yayoi, Sárdy, Miklós, Wu, Chuanjin, Chavakis, Triantafyllos, Udey, Mark C

“…OBJECTIVE—MFG-E8 (also called lactadherin and SED1) is a secreted glycoprotein that has been previously implicated in enhancement of vascular endothelial…”
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Meeting Report: Translational Considerations of Novel Vector Management Approaches by Costero-Saint Denis, Adriana, Leitner, Wolfgang W, Wali, Tonu, James, Stephanie

“…Are there conditions under which the novel strategy has a competitive advantage over other currently used disease control strategies? A target product profile…”
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Vaccination Using Gene-Gun Technology by Bergmann-Leitner, Elke S, Leitner, Wolfgang W

“…DNA vaccines against infection with Plasmodium have been highly successful in rodent models of malaria and have shown promise in the very limited number of…”
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Role of Opsonophagocytosis in Immune Protection against Malaria by Leitner, Wolfgang W., Haraway, Megan, Pierson, Tony, Bergmann-Leitner, Elke S.

“…The quest for immune correlates of protection continues to slow vaccine development. To date, only vaccine-induced antibodies have been confirmed as direct…”
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Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity by Chaudhury, Sidhartha, Duncan, Elizabeth H., Atre, Tanmaya, Dutta, Sheetij, Spring, Michele D., Leitner, Wolfgang W., Bergmann-Leitner, Elke S.

“…Adjuvants produce complex, but often subtle, effects on vaccine-induced immune responses that, nonetheless, play a critical role in vaccine efficacy. In-depth…”
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Workshop report: Optimization of animal models to better predict influenza vaccine efficacy by Lane, M. Chelsea, Gordon, Jennifer L., Jiang, Chao, Leitner, Wolfgang W., Pickett, Thames E., Stemmy, Erik, Bozick, Brooke A., Deckhut-Augustine, Alison, Embry, Alan C., Post, Diane J.

“…Animal models that can recapitulate the human immune system are essential for the preclinical development of safe and efficacious vaccines. Development and…”
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