Search Results - "Leitman, Dale"

2',3',4'-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism by Herber, Candice B, Yuan, Chaoshen, Chang, Anthony, Wang, Jen-Chywan, Cohen, Isaac, Leitman, Dale C

“…Menopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety concerns with…”
Get full text

Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells by Pan, Shawn, Yuan, Chaoshen, Tagmount, Abderrahmane, Rudel, Ruthann A, Ackerman, Janet M, Yaswen, Paul, Vulpe, Chris D, Leitman, Dale C

“…Xenoestrogens are synthetic compounds that mimic endogenous estrogens by binding to and activating estrogen receptors. Exposure to estrogens and to some…”
Get full text

Estrogen receptor β inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest by PARUTHIYIL, Sreenivasan, PARMAR, Hema, KEREKATTE, Vaishali, CUNHA, Gerald R, FIRESTONE, Gary L, LEITMAN, Dale C

“…Studies indicate that estrogen receptor (ER) alpha mediates breast cancer-promoting effects of estrogens. The role of ERbeta in breast cancer is unknown…”
Get full text

Estrogen receptor β causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2 by Paruthiyil, Sreenivasan, Cvoro, Aleksandra, Tagliaferri, Mary, Cohen, Isaac, Shtivelman, Emma, Leitman, Dale C.

“…The role of estrogen receptor beta (ERβ) in breast cancer is unclear. ERβ is considered to have a protective role in breast cancer development based on…”
Get full text

Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes by Cvoro, Aleksandra, Tatomer, Deirdre, Tee, Meng-Kian, Zogovic, Tatjana, Harris, Heather A, Leitman, Dale C

“…In addition to their role in the development and function of the reproductive system, estrogens have significant anti-inflammatory properties. Although both…”
Get full text

Estrogen Receptor β Binds to and Regulates Three Distinct Classes of Target Genes by Vivar, Omar I., Zhao, Xiaoyue, Saunier, Elise F., Griffin, Chandi, Mayba, Oleg S., Tagliaferri, Mary, Cohen, Isaac, Speed, Terence P., Leitman, Dale C.

“…Estrogen receptor β (ERβ) has potent antiproliferative and anti-inflammatory properties, suggesting that ERβ-selective agonists might be a new class of…”
Get full text

Regulation of specific target genes and biological responses by estrogen receptor subtype agonists by Leitman, Dale C, Paruthiyil, Sreenivasan, Vivar, Omar I, Saunier, Elise F, Herber, Candice B, Cohen, Isaac, Tagliaferri, Mary, Speed, Terence P

“…Estrogenic effects are mediated through two estrogen receptor (ER) subtypes, ERα and ERβ. Estrogens are the most commonly prescribed drugs to treat menopausal…”
Get full text

Distinct Roles of Unliganded and Liganded Estrogen Receptors in Transcriptional Repression by Cvoro, Aleksandra, Tzagarakis-Foster, Christina, Tatomer, Deirdre, Paruthiyil, Sreenivasan, Fox, Mark S., Leitman, Dale C.

“…The decline in estrogen levels during menopause is associated with increased cytokine production and inflammatory diseases. Estrogens exert anti-inflammatory…”
Get full text

Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists by Paruthiyil, Sreenivasan, Cvoro, Aleksandra, Zhao, Xiaoyue, Wu, Zhijin, Sui, Yunxia, Staub, Richard E, Baggett, Scott, Herber, Candice B, Griffin, Chandi, Tagliaferri, Mary, Harris, Heather A, Cohen, Isaac, Bjeldanes, Leonard F, Speed, Terence P, Schaufele, Fred, Leitman, Dale C

“…Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be…”
Get full text

Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist by Mersereau, Jennifer E., Levy, Nitzan, Staub, Richard E., Baggett, Scott, Zogric, Tetjana, Chow, Sylvia, Ricke, William A., Tagliaferri, Mary, Cohen, Isaac, Bjeldanes, Leonard F., Leitman, Dale C.

“…After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs to treat menopausal symptoms…”
Get full text

Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes by Cvoro, Aleksandra, Yuan, Chaoshen, Paruthiyil, Sreenivasan, Miller, Oliver H, Yamamoto, Keith R, Leitman, Dale C

“…Glucocorticoids exert potent anti-inflammatory effects by repressing proinflammatory genes. We previously demonstrated that estrogens repress numerous…”
Get full text

MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms by Leitman, Dale C, Christians, Uwe

“…The Women's Health Initiative Estrogen Plus Progestin clinical trial demonstrated the risks exceeded the benefits which have led to a decline in menopausal…”
Get more information

Alternate Surfaces of Transcriptional Coregulator GRIP1 Function in Different Glucocorticoid Receptor Activation and Repression Contexts by Rogatsky, Inez, Luecke, Hans F., Leitman, Dale C., Yamamoto, Keith R.

“…Members of the mammalian p160 family, such as GRIP1, are known as glucocorticoid receptor (GR) coactivators; at certain glucocorticoid response elements…”
Get full text

Estrogen receptor beta-selective agonists stimulate calcium oscillations in human and mouse embryonic stem cell-derived neurons by Zhang, Lili, Blackman, Brigitte E, Schonemann, Marcus D, Zogovic-Kapsalis, Tatjana, Pan, Xiaoyu, Tagliaferri, Mary, Harris, Heather A, Cohen, Isaac, Pera, Renee A Reijo, Mellon, Synthia H, Weiner, Richard I, Leitman, Dale C

“…Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone therapy on the brain might be…”
Get full text

Intergroup variation in oestrogenic plant consumption by black‐and‐white colobus monkeys by Benavidez, Kathryn M., Chapman, Colin A., Leitman, Dale C., Harris, Tara R., Wasserman, Michael D.

Get full text

Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta by Tee, Meng Kian, Rogatsky, Inez, Tzagarakis-Foster, Christina, Cvoro, Aleksandra, An, Jinping, Christy, Robert J, Yamamoto, Keith R, Leitman, Dale C

“…Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen receptor (ER) alpha and beta to activate or repress gene transcription. To…”
Get full text

Tissue-specific regulation of genes by estrogen receptors by Leitman, Dale C, Paruthiyil, Sreenivasan, Yuan, Chaoshen, Herber, Candice B, Olshansky, Moshe, Tagliaferri, Mary, Cohen, Isaac, Speed, Terence P

“…Estrogens are frequently used in reproductive medicine. The Women's Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the…”
Get more information

Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation by Saunier, Elise F, Vivar, Omar I, Rubenstein, Andrea, Zhao, Xiaoyue, Olshansky, Moshe, Baggett, Scott, Staub, Richard E, Tagliaferri, Mary, Cohen, Isaac, Speed, Terence P, Baxter, John D, Leitman, Dale C

“…Long-term estrogen deficiency increases the risk of obesity, diabetes and metabolic syndrome in postmenopausal women. Menopausal hormone therapy containing…”
Get full text

Selective Activation of Estrogen Receptor-β Target Genes by 3,3′-Diindolylmethane by Vivar, Omar I, Saunier, Elise F, Leitman, Dale C, Firestone, Gary L, Bjeldanes, Leonard F

“…3,3′-Diindolylmethane (DIM) is a natural compound found in cruciferous vegetables that has antiproliferative and estrogenic activity. However, it is not clear…”
Get full text

Estrogens Activate Bone Morphogenetic Protein-2 Gene Transcription in Mouse Mesenchymal Stem Cells by Zhou, Shuanhu, Turgeman, Gadi, Harris, Stephen E, Leitman, Dale C, Komm, Barry S, Bodine, Peter V. N, Gazit, Dan

“…Estrogens exert their physiological effects on target tissues by interacting with the estrogen receptors, ERα and ERβ. Estrogen replacement is one the most…”
Get full text