Search Results - "Leiting, Jennifer L"

Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas by Lenkiewicz, Elizabeth, Malasi, Smriti, Hogenson, Tara L, Flores, Luis F, Barham, Whitney, Phillips, William J, Roesler, Alexander S, Chambers, Kendall R, Rajbhandari, Nirakar, Hayashi, Akimasa, Antal, Corina E, Downes, Michael, Grandgenett, Paul M, Hollingsworth, Michael A, Cridebring, Derek, Xiong, Yuning, Lee, Jeong-Heon, Ye, Zhenqing, Yan, Huihuang, Hernandez, Matthew C, Leiting, Jennifer L, Evans, Ronald M, Ordog, Tamas, Truty, Mark J, Borad, Mitesh J, Reya, Tannishtha, Von Hoff, Daniel D, Fernandez-Zapico, Martin E, Barrett, Michael T

“…Adenosquamous cancer of the pancreas (ASCP) is a subtype of pancreatic cancer that has a worse prognosis and greater metastatic potential than the more common…”
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FDG-PET Predicts Neoadjuvant Therapy Response and Survival in Borderline Resectable/Locally Advanced Pancreatic Adenocarcinoma by Abdelrahman, Amro M, Goenka, Ajit H, Alva-Ruiz, Roberto, Yonkus, Jennifer A, Leiting, Jennifer L, Graham, Rondell P, Merrell, Kenneth W, Thiels, Cornelius A, Hallemeier, Christopher L, Warner, Susanne G, Haddock, Michael G, Grotz, Travis E, Tran, Nguyen H, Smoot, Rory L, Ma, Wen Wee, Cleary, Sean P, McWilliams, Robert R, Nagorney, David M, Halfdanarson, Thorvardur R, Kendrick, Michael L, Truty, Mark J

“…Neoadjuvant therapy (NAT) is used in borderline resectable/locally advanced (BR/LA) pancreatic ductal adenocarcinoma (PDAC). Anatomic imaging (CT/MRI) poorly…”
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Successful Secondary Engraftment of Pancreatic Ductal Adenocarcinoma and Cholangiocarcinoma Patient-Derived Xenografts After Previous Failed Primary Engraftment by Hernandez, Matthew C., Yang, Lin, Leiting, Jennifer L., Sugihara, Takaaki, Bergquist, John R., Ivanics, Tommy, Graham, Rondell, Truty, Mark J.

“…BACKGROUND: Patient-derived xenografts (PDX) provide histologically accurate cancer models that recapitulate patient malignant phenotype and allow for highly…”
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In vivo label-free optical signatures of chemotherapy response in human pancreatic ductal adenocarcinoma patient-derived xenografts by Park, Jaena, Sorrells, Janet E., Chaney, Eric J., Abdelrahman, Amro M., Yonkus, Jennifer A., Leiting, Jennifer L., Nelson, Heidi, Harrington, Jonathan J., Aksamitiene, Edita, Marjanovic, Marina, Groves, Peter D., Bushell, Colleen, Truty, Mark J., Boppart, Stephen A.

“…Pancreatic cancer is a devastating disease often detected at later stages, necessitating swift and effective chemotherapy treatment. However, chemoresistance…”
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The impact of HIPEC vs. EPIC for the treatment of mucinous appendiceal carcinoma: a study from the US HIPEC collaborative by Leiting, Jennifer L., Day, Courtney N., Harmsen, William S., Cloyd, Jordan M., Abdel-Misih, Sherif, Fournier, Keith, Lee, Andrew J., Dineen, Sean, Dessureault, Sophie, Veerapongh, Jula, Baumgartner, Joel M., Clarke, Callisia, Mogal, Harveshp, Russell, Maria C., Zaidi, Mohammad Y., Patel, Sameer H., Morris, Mackenzie C., Hendrix, Ryan J., Lambert, Laura A., Abbott, Daniel E., Pokrzywa, Courtney, Raoof, Mustafa, Eng, Oliver, Johnston, Fabian M., Greer, Jonathan, Grotz, Travis E.

“…Mucinous appendiceal carcinoma is a rare malignancy that commonly spreads to the peritoneum leading to peritoneal metastases. Complete cytoreduction with…”
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Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine by Leiting, Jennifer L., Murphy, Stephen J., Bergquist, John R., Hernandez, Matthew C., Ivanics, Tommy, Abdelrahman, Amro M., Yang, Lin, Lynch, Isaac, Smadbeck, James B., Cleary, Sean P., Nagorney, David M., Torbenson, Michael S., Graham, Rondell P., Roberts, Lewis R., Gores, Gregory J., Smoot, Rory L., Truty, Mark J.

“…Biliary tract tumors are uncommon but highly aggressive malignancies with poor survival outcomes. Due to their low incidence, research into effective…”
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Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size by Grotz, Travis E., Truty, Mark J., Robinson, Steven I., Folpe, Andrew L., Merrell, Kenneth W., Hernandez, Matthew C., Bergquist, John R., Leiting, Jennifer L., Nagorney, D. M.

“…Perioperative radiation therapy (RT) has been associated with reduced local recurrence in patients with retroperitoneal sarcomas (RPS); however, selection…”
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Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features by Bergquist, John R., Leiting, Jennifer L., Habermann, Elizabeth B., Cleary, Sean P., Kendrick, Michael L., Smoot, Rory L., Nagorney, David M., Truty, Mark J., Grotz, Travis E.

“…Overall the incidence of gastric cancer is declining in the United States; however, the incidence of early-onset gastric cancer is increasing. We sought to…”
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Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens by Hernandez, Matthew C., Bergquist, John R., Leiting, Jennifer L., Ivanics, Tommy, Yang, Lin, Smoot, Rory L., Nagorney, David M., Truty, Mark J.

“…Background Patient-derived xenografts (PDX) are clinically relevant human cancer models that can be used to guide individualized medicine. We aimed to generate…”
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Patient-derived xenografts in surgical oncology: A short research review by Hernandez, Matthew C., Leiting, Jennifer L., Joshi, Vidhu B., Yang, Lin, Leong, Hon, Thomas, Ryan M., Fleming, Jason, Truty, Mark J.

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Advancements and challenges in treating advanced gastric cancer in the West by Leiting, Jennifer L, Grotz, Travis E

“…Gastric cancer is a leading cause of cancer incidence and death worldwide. Patients with advanced gastric cancer benefit from a multi-modality treatment…”
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Conditional Survival Following Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: An Analysis from the US HIPEC Collaborative by Beal, Eliza W., Srinivas, Shruthi, Shen, Chengli, Kim, Alex, Johnston, Fabian M., Greer, Jonathan, Abbott, Daniel E., Pokrzywa, Courtney, Raoof, Mustafa, Grotz, Travis E., Leiting, Jennifer L., Fournier, Keith, Dineen, Sean, Powers, Benjamin, Veerapong, Jula, Kothari, Anai, Maduekew, Ugwuji, Maithel, Shishir, Wilson, Gregory C., Patel, Sameer H., Lambert, Laura, Abdel-Misih, Sherif, Cloyd, Jordan M.

“…Introduction The long-term prognosis of patients who undergo cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal…”
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ASO Visual Abstract: Conditional Survival After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancies: An Analysis from the US HIPEC Collaborative by Beal, Eliza W., Srinivas, Shruthi, Shen, Chengli, Kim, Alex, Johnston, Fabian M., Greer, Jonathan, Abbott, Daniel E., Pokrzywa, Courtney, Raoof, Mustafa, Grotz, Travis E., Leiting, Jennifer L., Fournier, Keith, Dineen, Sean, Powers, Benjamin, Veerapong, Jula, Kothari, Anai, Maduekew, Ugwuji, Maithel, Shishir, Wilson, Gregory C., Patel, Sameer H., Lambert, Laura, Abdel-Misih, Sherif, Cloyd, Jordan M.

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Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening by Lalazar, Gadi, Requena, David, Ramos-Espiritu, Lavoisier, Ng, Denise, Bhola, Patrick D, de Jong, Ype P, Wang, Ruisi, Narayan, Nicole J C, Shebl, Bassem, Levin, Solomon, Michailidis, Eleftherios, Kabbani, Mohammad, Vercauteren, Koen O A, Hurley, Arlene M, Farber, Benjamin A, Hammond, William J, Saltsman, 3rd, James A, Weinberg, Ethan M, Glickman, J Fraser, Lyons, Barbara A, Ellison, Jessica, Schadde, Erik, Hertl, Martin, Leiting, Jennifer L, Truty, Mark J, Smoot, Rory L, Tierney, Faith, Kato, Tomoaki, Wendel, Hans-Guido, LaQuaglia, Michael P, Rice, Charles M, Letai, Anthony, Coffino, Philip, Torbenson, Michael S, Ortiz, Michael V, Simon, Sanford M

“…To repurpose therapeutics for fibrolamellar carcinoma (FLC), we developed and validated patient-derived xenografts (PDX) from surgical resections. Most agents…”
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Molecular Peritoneal Staging for Pancreatic Ductal Adenocarcinoma Using Mutant KRAS Droplet-Digital Polymerase Chain Reaction: Results of a Prospective Clinical Trial by Yonkus, Jennifer A., Alva-Ruiz, Roberto, Abdelrahman, Amro M., Leiting, Jennifer L., Schneider, Amber R., Grotz, Travis E., Cleary, Sean P., Smoot, Rory L., Nagorney, David M., Kendrick, Michael L., Kipp, Benjamin R., Truty, Mark J.

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with predilection for peritoneal dissemination. Accurate peritoneal staging is imperative…”
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Rituximab Decreases Lymphoproliferative Tumor Formation in Hepatopancreaticobiliary and Gastrointestinal Cancer Patient-Derived Xenografts by Leiting, Jennifer L., Hernandez, Matthew C., Yang, Lin, Bergquist, John R., Ivanics, Tommy, Graham, Rondell P., Truty, Mark J.

“…High engraftment rates are critical to any patient-derived xenograft (PDX) program and the loss of PDX models due to the development of lymphoproliferative…”
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Therapeutic Efficacy of Temsirolimus in a Patient-derived Model of Metastatic Fibrolamellar Hepatocellular Carcinoma by Leiting, Jennifer L, Hernandez, Matthew C, Bergquist, John R, Yonkus, Jennifer A, Abdelrahman, Amro M, Torbenson, Michael S, Tran, Nguyen H, Halfdanarson, Thorvardur R, Graham, Rondell P, Smoot, Rory L, Truty, Mark J

“…Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare tumor presenting in younger patients without chronic liver disease. Up to 80-100% develop recurrent…”
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Evaluation of NUC-1031: a first-in-class ProTide in biliary tract cancer by Arora, Mansi, Bogenberger, James M., Abdelrahman, Amro, Leiting, Jennifer L., Chen, Xianfeng, Egan, Jan B., Kasimsetty, Aradhana, Lenkiewicz, Elzbieta, Malasi, Smriti, Uson, Pedro Luiz Serrano, Nagalo, Bolni Marius, Zhou, Yumei, Salomao, Marcela A., Kosiorek, Heidi E., Braggio, Esteban, Barrett, Michael T., Truty, Mark J., Borad, Mitesh J.

“…Purpose NUC1031 is a first-in-class ProTide, that is a gemcitabine pro-drug designed to overcome putative mechanisms of resistance, including decreased…”
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Synergistic combination of cytotoxic chemotherapy and cyclin‐dependent kinase 4/6 inhibitors in biliary tract cancers by Arora, Mansi, Bogenberger, James M., Abdelrahman, Amro M., Yonkus, Jennifer, Alva‐Ruiz, Roberto, Leiting, Jennifer L., Chen, Xianfeng, Serrano Uson Junior, Pedro Luiz, Dumbauld, Chelsae R., Baker, Alexander T., Gamb, Scott I., Egan, Jan B., Zhou, Yumei, Nagalo, Bolni Marius, Meurice, Nathalie, Eskelinen, Eeva‐Liisa, Salomao, Marcela A., Kosiorek, Heidi E., Braggio, Esteban, Barrett, Michael T., Buetow, Kenneth H., Sonbol, Mohamad B., Mansfield, Aaron S., Roberts, Lewis R., Bekaii‐Saab, Tanios S., Ahn, Daniel H., Truty, Mark J., Borad, Mitesh J.

“…Background and aims Biliary tract cancers (BTCs) are uncommon, but highly lethal, gastrointestinal malignancies. Gemcitabine/cisplatin is a standard‐of‐care…”
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Transversus abdominis plane blocks with liposomal bupivacaine after open major hepatectomy is associated with reduced early patient-reported pain scores and opioid administration by Hernandez, Matthew C., Panchamia, Jason, Finnesgard, Eric J., Leiting, Jennifer L., Franssen, Bernardo, Saleem, Humza, Kendrick, Michael L., Nagorney, David M., Truty, Mark J., Smoot, Rory L.

“…Opioid overprescription can contribute to suboptimal patient outcomes. Surgeon-performed transversus abdominis plane blocks appear to be associated with pain…”
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