Search Results - "Leithauser, Frank"

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity by Messmann, Joanna J., Reisser, Tanja, Leithäuser, Frank, Lutz, Manfred B., Debatin, Klaus-Michael, Strauss, Gudrun

“…Myeloid-derived suppressor cells (MDSCs) inhibit T-cell expansion and functions by versatile mechanisms such as nutrient depletion, nitrosylation, or…”
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Commensal gut flora drives the expansion of proinflammatory CD4 T cells in the colonic lamina propria under normal and inflammatory conditions by Niess, Jan Hendrik, Leithäuser, Frank, Adler, Guido, Reimann, Jörg

“…We tested in B6 mice whether the local expansion of CD4 T cells producing proinflammatory cytokines including IL-17 (Th17 cells) in the colonic lamina propria…”
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FOXO1 is a tumor suppressor in classical Hodgkin lymphoma by Xie, Linka, Ushmorov, Alexey, Leithäuser, Frank, Guan, Hanfeng, Steidl, Christian, Färbinger, Johanna, Pelzer, Christin, Vogel, Marion J., Maier, Harald J., Gascoyne, Randy D., Möller, Peter, Wirth, Thomas

“…The FOXO transcription factors control proliferation and apoptosis in different cell types. Their activity is regulated by posttranslational modifications,…”
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Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma by He, Jiajia, Gerstenlauer, Melanie, Chan, Lap Kwan, Leithäuser, Frank, Yeh, Matthew M., Wirth, Thomas, Maier, Harald J.

“…Primary liver cancer ranks among the leading causes of cancer death worldwide. Risk factors are closely linked to inflammation, such as viral hepatitis and…”
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Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma by Ushmorov, Alexey, Leithäuser, Frank, Sakk, Olena, Weinhaüsel, Andreas, Popov, Sergey W., Möller, Peter, Wirth, Thomas

“…Many B-lineage-specific genes are down-regulated in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL). We investigated the involvement…”
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KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma by Guan, Hanfeng, Xie, Linka, Leithäuser, Frank, Flossbach, Lucia, Möller, Peter, Wirth, Thomas, Ushmorov, Alexey

“…The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to…”
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Usefulness of BATF3 Immunohistochemistry in Diagnosing Classical Hodgkin Lymphoma by Benckendorff, Julian, Kuchar, Johanna, Leithäuser, Frank, Zahn, Malena, Möller, Peter

“…It is well recognized that the AP-1 transcription factor BATF3 is constitutively expressed in Hodgkin/Reed-Sternberg (HRS) cells, but its potential as a…”
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CDK9 is a prognostic marker and therapeutic target in pancreatic cancer by Kretz, Anna-Laura, Schaum, Monika, Richter, Julia, Kitzig, Ella F, Engler, Christine C, Leithäuser, Frank, Henne-Bruns, Doris, Knippschild, Uwe, Lemke, Johannes

“…Despite recent advances in diagnosis and therapy, prognosis of pancreatic cancer still remains very poor. Besides valid prognostic markers, novel therapeutic…”
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Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line by Melzner, Ingo, Bucur, Alexandra Juliana, Brüderlein, Silke, Dorsch, Karola, Hasel, Cornelia, Barth, Thomas F.E., Leithäuser, Frank, Möller, Peter

“…Primary mediastinal B-cell lymphoma (PMBL) is a well-defined subtype of diffuse large B-cell lymphoma. Molecular cytogenetics revealed frequent gains of 9p24…”
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CK1α overexpression correlates with poor survival in colorectal cancer by Richter, Julia, Kretz, Anna-Laura, Lemke, Johannes, Fauler, Michael, Werner, Jens-Uwe, Paschke, Stephan, Leithäuser, Frank, Henne-Bruns, Doris, Hillenbrand, Andreas, Knippschild, Uwe

“…Colorectal cancer (CRC) is the fourth leading cause of cancer related deaths worldwide and prognosis in advanced tumor stage still remains poor. Since CK1…”
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IL-22-Dependent Attenuation of T Cell-Dependent (ConA) Hepatitis in Herpes Virus Entry Mediator Deficiency by Wahl, Christian, Wegenka, Ursula Maria, Leithauser, Frank, Schirmbeck, Reinhold, Reimann, Jorg

“…Coinhibitors and costimulators control intrahepatic T cell responses that trigger acute hepatitis. We used the ConA-induced hepatitis model in the mouse to…”
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IL-20 Receptor 2 Signaling Down-Regulates Antigen-Specific T Cell Responses by Wahl, Christian, Muller, Werner, Leithauser, Frank, Adler, Guido, Oswald, Franz, Reimann, Jorg, Schirmbeck, Reinhold, Seier, Anne, Weiss, Johannes Martin, Prochnow, Blair, Wegenka, Ursula Maria

“…The recently described cytokines IL-19, IL-20, and IL-24 share structural homology with IL-10 and are therefore classified as members of the IL-10 family of…”
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Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis by Chan, Lap Kwan, Tsesmelis, Miltiadis, Gerstenlauer, Melanie, Leithäuser, Frank, Kleger, Alexander, Frick, Lukas Daniel, Maier, Harald Jacob, Wirth, Thomas

“…Pancreatic stellate cells (PSCs) are resident cells in the exocrine pancreas which contribute to pancreatic fibrogenesis and inflammation. Studies on NF-κB in…”
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Safety of Probiotic Escherichia coli Strain Nissle 1917 Depends on Intestinal Microbiota and Adaptive Immunity of the Host by Gronbach, Kerstin, Eberle, Ute, Müller, Martina, Ölschläger, Tobias A, Dobrindt, Ulrich, Leithäuser, Frank, Niess, Jan Hendrik, Döring, Gerd, Reimann, Jörg, Autenrieth, Ingo B, Frick, Julia-Stefanie

“…Probiotics are viable microorganisms that are increasingly used for treatment of a variety of diseases. Occasionally, however, probiotics may have adverse…”
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Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression by Ushmorov, Alexey, Ritz, Olga, Hummel, Michael, Leithäuser, Frank, Möller, Peter, Stein, Harald, Wirth, Thomas

“…Immunoglobulin production is impaired in Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) in spite of functional clonal…”
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Myc Regulates Embryonic Vascular Permeability and Remodeling by Kokai, Enikö, Voss, Florian, Fleischer, Frank, Kempe, Sybille, Marinkovic, Dragan, Wolburg, Hartwig, Leithäuser, Frank, Schmidt, Volker, Deutsch, Urban, Wirth, Thomas

“…Previous work has shown that c-Myc is required for adequate vasculogenesis and angiogenesis. To further investigate the contribution of Myc to these processes,…”
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Nck adaptor proteins modulate differentiation and effector function of T cells by Lu, Kun‐Hui, Keppler, Selina, Leithäuser, Frank, Mattfeldt, Torsten, Castello, Angelo, Kostezka, Ulrike, Küblbeck, Günter, Schmitt, Sabine, Klevenz, Alexandra, Prokosch, Sandra, Pougialis, Georg, Pawson, Tony, Batista, Facundo, Tafuri, Anna, Arnold, Bernd

“…Loss of Nck proteins in T cells impairs germinal center formation, Tfh cell survival, cytokine production, and T cell‐dependent antibody responses…”
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Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo by Hirner, Heidrun, Günes, Cagatay, Bischof, Joachim, Wolff, Sonja, Grothey, Arnhild, Kühl, Marion, Oswald, Franz, Wegwitz, Florian, Bösl, Michael R, Trauzold, Anna, Henne-Bruns, Doris, Peifer, Christian, Leithäuser, Frank, Deppert, Wolfgang, Knippschild, Uwe

“…Simian virus 40 (SV40) is a powerful tool to study cellular transformation in vitro, as well as tumor development and progression in vivo. Various cellular…”
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3'-[18F]fluoro-3'-deoxythymidine ([18F]-FLT) as positron emission tomography tracer for imaging proliferation in a murine B-cell lymphoma model and in the human disease by WAGNER, Martin, SEITZ, Ulrike, RESKE, Sven N, BUCK, Andreas, NEUMAIER, Bernd, SCHULLHEISS, Stefan, BANGERTER, Markus, BOMMER, Martin, LEITHÄUSER, Frank, WAWRA, Edgar, MUNZERT, Gerd

“…Here we describe the evaluation of 3'-[(18)F]fluoro-3'-deoxythymidine [[(18)F]-FLT] as a tracer for positron emission tomography (PET) in a murine model of…”
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Foxp3-Expressing CD103 + Regulatory T Cells Accumulate in Dendritic Cell Aggregates of the Colonic Mucosa in Murine Transfer Colitis by Leithäuser, Frank, Meinhardt-Krajina, Tamara, Fink, Kerstin, Wotschke, Beate, Möller, Peter, Reimann, Jörg

“…Little is known of the anatomical compartmentalization of colitogenic or regulatory T-cell responses in the murine transfer colitis model. Therefore, we…”
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