Search Results - "Leiter, James C."
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Electrocardiogram-synchronized pulsatile extracorporeal life support preserves left ventricular function and coronary flow in a porcine model of cardiogenic shock
Published in PloS one (24-04-2018)“…Veno-arterial extracorporeal life support (ECLS) is increasingly being used to treat rapidly progressing or severe cardiogenic shock. However, it has been…”
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In Search of a Feedback Signal for Closed-Loop Deep Brain Stimulation: Stimulation of the Subthalamic Nucleus Reveals Altered Glutamate Dynamics in the Globus Pallidus in Anesthetized, 6-Hydroxydopamine-Treated Rats
Published in Biosensors (Basel) (01-04-2023)“…Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is a surgical procedure for alleviating motor symptoms of Parkinson's Disease (PD). The pattern…”
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Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury
Published in Scientific reports (11-05-2022)“…Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined…”
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Complexity of the Nano-Bio Interface and the Tortuous Path of Metal Oxides in Biological Systems
Published in Antioxidants (01-04-2021)“…Metal oxide nanoparticles (NPs) have received a great deal of attention as potential theranostic agents. Despite extensive work on a wide variety of metal…”
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Antioxidant Enzyme-Mimetic Activity and Neuroprotective Effects of Cerium Oxide Nanoparticles Stabilized with Various Ratios of Citric Acid and EDTA
Published in Biomolecules (Basel, Switzerland) (03-10-2019)“…Cerium oxide (CeO ) nanoparticles (CeNPs) are potent antioxidants that are being explored as potential therapies for diseases in which oxidative stress plays…”
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Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte-Neuron Lactate-Shuttle Hypothesis
Published in The Journal of neuroscience (07-05-2008)“…The astrocyte-neuronal lactate-shuttle hypothesis posits that lactate released from astrocytes into the extracellular space is metabolized by neurons. The…”
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Effectiveness of a Novel Qigong Meditative Movement Practice for Impaired Health in Flight Attendants Exposed to Second-Hand Cigarette Smoke
Published in Frontiers in human neuroscience (21-02-2017)“…This single-arm non-randomized pilot study explores an intervention to improve the health of flight attendants (FA) exposed to second-hand cigarette smoke…”
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Clinical measurements obtained from point-of-care ultrasound images to assess acquisition skills
Published in The ultrasound journal (22-02-2019)“…Background Current methods of assessing competence in acquiring point-of-care ultrasound images are inadequate. They rely upon cumbersome rating systems that…”
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9
Time-dependent statistical and correlation properties of neural signals during handwriting
Published in PloS one (11-09-2012)“…To elucidate the cortical control of handwriting, we examined time-dependent statistical and correlational properties of simultaneously recorded 64-channel…”
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Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain
Published in ACS nano (23-12-2013)“…Cerium oxide nanoparticles are potent antioxidants, based on their ability to either donate or receive electrons as they alternate between the +3 and +4…”
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Take a deep breath and wake up: The protean role of serotonin preventing sudden death in infancy
Published in Experimental neurology (01-04-2020)“…Recordings from infants who died suddenly and unexpectedly demonstrate the occurrence of recurring apneas, ineffective gasping, and finally, failure to restore…”
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Platinum-Doped Ceria Based Biosensor for in Vitro and in Vivo Monitoring of Lactate during Hypoxia
Published in Analytical chemistry (Washington) (03-03-2015)“…Measurements of lactate concentrations in blood and tissues are an important indication of the adequacy of tissue oxygenation and could be useful for…”
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Cervical Epidural Electrical Stimulation Increases Respiratory Activity through Somatostatin-Expressing Neurons in the Dorsal Cervical Spinal Cord in Rats
Published in The Journal of neuroscience (18-01-2023)“…We tested the hypothesis that dorsal cervical epidural electrical stimulation (CEES) increases respiratory activity in male and female anesthetized rats…”
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Muscles of Breathing: Development, Function, and Patterns of Activation
Published in Comprehensive Physiology (12-06-2019)“…This review is a comprehensive description of all muscles that assist lung inflation or deflation in any way. The developmental origin, anatomical orientation,…”
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Deep Brain Stimulation Results in Local Glutamate and Adenosine Release: Investigation Into the Role of Astrocytes
Published in Neurosurgery (01-08-2010)“…Abstract BACKGROUND Several neurological disorders are treated with deep brain stimulation; however, the mechanism underlying its ability to abolish…”
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Epidural electrical stimulation of the cervical spinal cord opposes opioid‐induced respiratory depression
Published in The Journal of physiology (01-06-2022)“…Opioid overdose suppresses brainstem respiratory circuits, causes apnoea and may result in death. Epidural electrical stimulation (EES) at the cervical spinal…”
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Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis
Published in Journal of neuropathology and experimental neurology (21-02-2024)“…Abstract The failure of chemoreflexes, arousal, and/or autoresuscitation to asphyxia may underlie some sudden infant death syndrome (SIDS) cases. In Part I, we…”
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Unilateral Carotid Body Resection in Resistant Hypertension
Published in JACC. Basic to translational science (01-08-2016)“…Summary Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood…”
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Unilateral Carotid Body Resection in Resistant Hypertension: A Safety and Feasibility Trial
Published in JACC. Basic to translational science (01-08-2016)“…Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood…”
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Modulation of respiratory output by cervical epidural stimulation in the anesthetized mouse
Published in Journal of applied physiology (1985) (01-12-2016)“…Respiration is produced and controlled by well-characterized brain stem nuclei, but the contributions of spinal circuits to respiratory control and modulation…”
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