Search Results - "Leitch, C. C"

Specific Association of Human Parechovirus Type 3 with Sepsis and Fever in Young Infants, as Identified by Direct Typing of Cerebrospinal Fluid Samples by Harvala, H. , Robertson, I. , Chieochansin, T. , McWilliam Leitch, E. C. , Templeton, K. , Simmonds, P. 

“…Background. Human parechoviruses (HPeVs), along with human enteroviruses (HEVs), are associated with neonatal sepsis and meningitis. We determined the relative…”
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Screening Respiratory Samples for Detection of Human Rhinoviruses (HRVs) and Enteroviruses: Comprehensive VP4-VP2 Typing Reveals High Incidence and Genetic Diversity of HRV Species C by Wisdom, A, Leitch, E.C. McWilliam, Gaunt, E, Harvala, H, Simmonds, P

“…Rhinovirus infections are the most common cause of viral illness in humans, and there is increasing evidence of their etiological role in severe acute…”
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Comparison of diagnostic clinical samples and environmental sampling for enterovirus and parechovirus surveillance in Scotland, 2010 to 2012 by Harvala, H, Calvert, J, Van Nguyen, D, Clasper, L, Gadsby, N, Molyneaux, P, Templeton, K, McWilliams Leitch, C, Simmonds, P

“…Human enteroviruses (EV) and parechoviruses (HPeV) within the family Picornaviridae are the most common causes of viral central nervous system (CNS)-associated…”
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Chiral, air stable, and reliable Pd(0) precatalysts applicable to asymmetric allylic alkylation chemistry by Huang, Jingjun, Keenan, Thomas, Richard, François, Lu, Jingru, Jenny, Sarah E., Jean, Alexandre, Arseniyadis, Stellios, Leitch, David C.

“…Stereoselective carbon-carbon bond formation via palladium-catalyzed asymmetric allylic alkylation is a crucial strategy to access chiral natural products and…”
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ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response by Adeyemo, Adebowale A., Zaghloul, Norann A., Chen, Guanjie, Doumatey, Ayo P., Leitch, Carmen C., Hostelley, Timothy L., Nesmith, Jessica E., Zhou, Jie, Bentley, Amy R., Shriner, Daniel, Fasanmade, Olufemi, Okafor, Godfrey, Eghan, Benjamin, Agyenim-Boateng, Kofi, Chandrasekharappa, Settara, Adeleye, Jokotade, Balogun, William, Owusu, Samuel, Amoah, Albert, Acheampong, Joseph, Johnson, Thomas, Oli, Johnnie, Adebamowo, Clement, Collins, Francis, Dunston, Georgia, Rotimi, Charles N.

“…Genome analysis of diverse human populations has contributed to the identification of novel genomic loci for diseases of major clinical and public health…”
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Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response by Liu, Yangfan, Gerdes, Jantje M, Zaghloul, Norann A, Fisher, Shannon, Badano, Jose L, Katsanis, Nicholas, Beales, Philip L, Leitch, Carmen C, Beachy, Philip A, Kato, Masaki, DeMartino, George N, Lawson, Shaneka S

“…Primary cilia and basal bodies are evolutionarily conserved organelles that mediate communication between the intracellular and extracellular environments…”
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Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols by Lim, John Jin, Leitch, David C

“…Benzophenone imine was found to be an effective ammonia surrogate for the selective preparation of primary 1,2-amino alcohols from epoxides, including…”
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Chiral Neutral Zirconium Amidate Complexes for the Asymmetric Hydroamination of Alkenes by Wood, Mark C., Leitch, David C., Yeung, Charles S., Kozak, Jennifer A., Schafer, Laurel L.

“…Aminations with amidates: The first C2‐symmetric amidate complexes of zirconium were used for catalytic asymmetric hydroaminations of amino alkenes to prepare…”
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Mechanistic Elucidation of Intramolecular Aminoalkene Hydroamination Catalyzed by a Tethered Bis(ureate) Complex: Evidence for Proton-Assisted C–N Bond Formation at Zirconium by Leitch, David C, Platel, Rachel H, Schafer, Laurel L

“…A broad mechanistic investigation regarding hydroamination reactions catalyzed by a tethered bis(ureate) zirconium species, [ureate(2−)]Zr(NMe2)2(HNMe2), is…”
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Broadening the Scope of Group 4 Hydroamination Catalysis Using a Tethered Ureate Ligand by Leitch, David C, Payne, Philippa R, Dunbar, Christine R, Schafer, Laurel L

“…A broadly applicable group-4-based precatalyst for the hydroamination of primary and secondary amines was developed. Screening experiments involving a series…”
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Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids by Young, Gregory R, Abdelghany, Tarek M, Leitch, Alistair C, Dunn, Michael P, Blain, Peter G, Lanyon, Clare, Wright, Matthew C

“…Ionic liquids are salts used in a variety of industrial processes, and being relatively non-volatile, are proposed as environmentally-friendly replacements for…”
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BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF by Leitch, Carmen C, Zaghloul, Norann A

“…Primary cilia regulate an expanding list of signaling pathways in many different cell types. It is likely that identification of the full catalog of pathways…”
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High-Throughput Discovery and Evaluation of a General Catalytic Method for N‑Arylation of Weakly Nucleophilic Sulfonamides by Becica, Joseph, Hruszkewycz, Damian P, Steves, Janelle E, Elward, Jennifer M, Leitch, David C, Dobereiner, Graham E

“…Through targeted high-throughput experimentation (HTE), we have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct…”
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Association of Recombination Events in the Founding and Emergence of Subgenogroup Evolutionary Lineages of Human Enterovirus 71 by McWilliam Leitch, E. C, Cabrerizo, M, Cardosa, J, Harvala, H, Ivanova, O. E, Koike, S, Kroes, A. C. M, Lukashev, A, Perera, D, Roivainen, M, Susi, P, Trallero, G, Evans, D. J, Simmonds, P

“…Enterovirus 71 (EV71) is responsible for frequent large-scale outbreaks of hand, foot, and mouth disease worldwide and represent a major etiological agent of…”
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A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 by Dietz, Harry C, Loeys, Bart L, Chen, Junji, Neptune, Enid R, Judge, Daniel P, Podowski, Megan, Holm, Tammy, Meyers, Jennifer, Leitch, Carmen C, Katsanis, Nicholas, Sharifi, Neda, Xu, F Lauren, Myers, Loretha A, Spevak, Philip J, Cameron, Duke E, Backer, Julie De, Hellemans, Jan, Chen, Yan, Davis, Elaine C, Webb, Catherine L, Kress, Wolfram, Coucke, Paul, Rifkin, Daniel B, De Paepe, Anne M

“…We report heterozygous mutations in the genes encoding either type I or type II transforming growth factor β receptor in ten families with a newly described…”
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Epidemiology and Clinical Associations of Human Parechovirus Respiratory Infections by Harvala, H, Robertson, I, McWilliam Leitch, E.C, Benschop, K, Wolthers, K.C, Templeton, K, Simmonds, P

“…Infections with human parechoviruses (HPeVs) are prevalent in young children and have been associated with mild gastroenteritis and, less frequently, with…”
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Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome by Katsanis, Nicholas, Ansley, Stephen J, Badano, Jose L, Blacque, Oliver E, Hill, Josephine, Hoskins, Bethan E, Leitch, Carmen C, Chul Kim, Jun, Ross, Alison J, Eichers, Erica R, Teslovich, Tanya M, Mah, Allan K, Johnsen, Robert C, Cavender, John C, Alan Lewis, Richard, Leroux, Michel R, Beales, Philip L

“…Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized primarily by retinal dystrophy, obesity, polydactyly, renal malformations and…”
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Upgrading Light Hydrocarbons via Tandem Catalysis: A Dual Homogeneous Ta/Ir System for Alkane/Alkene Coupling by Leitch, David C, Lam, Yan Choi, Labinger, Jay A, Bercaw, John E

“…Light alkanes and alkenes are abundant but are underutilized as energy carriers because of their high volatility and low energy density. A tandem catalytic…”
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RFX transcription factors are essential for hearing in mice by Elkon, Ran, Milon, Beatrice, Morrison, Laura, Shah, Manan, Vijayakumar, Sarath, Racherla, Manoj, Leitch, Carmen C., Silipino, Lorna, Hadi, Shadan, Weiss-Gayet, Michèle, Barras, Emmanuèle, Schmid, Christoph D., Ait-Lounis, Aouatef, Barnes, Ashley, Song, Yang, Eisenman, David J., Eliyahu, Efrat, Frolenkov, Gregory I., Strome, Scott E., Durand, Bénédicte, Zaghloul, Norann A., Jones, Sherri M., Reith, Walter, Hertzano, Ronna

“…Sensorineural hearing loss is a common and currently irreversible disorder, because mammalian hair cells (HCs) do not regenerate and current stem cell and gene…”
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Unraveling the New England orocline, east Gondwana accretionary margin by Cawood, P. A., Pisarevsky, S. A., Leitch, E. C.

“…The New England orocline lies within the Eastern Australian segment of the Terra Australis accretionary orogen and developed during the late Paleozoic to early…”
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