Search Results - "Leitch, A"

Mechanoredox Chemistry as an Emerging Strategy in Synthesis by Leitch, Jamie A., Browne, Duncan L.

“…Recent research endeavors have established that the mechanochemical activation of piezoelectric materials can open new avenues in redox chemistry. Impact…”
Get full text

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole by Leitch, Jamie A, Bhonoah, Yunas, Frost, Christopher G

“…The indole scaffold will continue to play a vital part in the future of drug discovery and agrochemical development. Because of this, the necessity for elegant…”
Get full text

Genomic Plasticity and the Diversity of Polyploid Plants by Leitch, A. R., Leitch, I. J.

“…Polyploidy, a change whereby the entire chromosome set is multiplied, arises through mitotic or meiotic misdivisions and frequently involves unreduced gametes…”
Get full text

Ecological and genetic factors linked to contrasting genome dynamics in seed plants by Leitch, A. R, Leitch, I. J

“…CONTENTS: Summary 629 I. Introduction – overview 629 II. Genome structures 631 III. Factors that have shaped the genomes of angiosperms and gymnosperms 640 IV…”
Get full text

Locoregional Recurrence After Sentinel Lymph Node Dissection With or Without Axillary Dissection in Patients With Sentinel Lymph Node Metastases: Long-term Follow-up From the American College of Surgeons Oncology Group (Alliance) ACOSOG Z0011 Randomized Trial by Giuliano, Armando E, Ballman, Karla, McCall, Linda, Beitsch, Peter, Whitworth, Pat W, Blumencranz, Peter, Leitch, A Marilyn, Saha, Sukamal, Morrow, Monica, Hunt, Kelly K

“…BACKGROUND AND OBJECTIVE:The early results of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial demonstrated no difference in locoregional…”
Get full text

Dearomative Photocatalytic Construction of Bridged 1,3‐Diazepanes by Leitch, Jamie A., Rogova, Tatiana, Duarte, Fernanda, Dixon, Darren J.

“…The construction of diverse sp3‐rich skeletal ring systems is of importance to drug discovery programmes and natural product synthesis. Herein, we report the…”
Get full text

Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial by Giuliano, Armando E, Ballman, Karla V, McCall, Linda, Beitsch, Peter D, Brennan, Meghan B, Kelemen, Pond R, Ollila, David W, Hansen, Nora M, Whitworth, Pat W, Blumencranz, Peter W, Leitch, A. Marilyn, Saha, Sukamal, Hunt, Kelly K, Morrow, Monica

“…IMPORTANCE: The results of the American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial were first reported in 2005 with a median follow-up of…”
Get full text

Catalytic Reductive Functionalization of Tertiary Amides using Vaska’s Complex: Synthesis of Complex Tertiary Amine Building Blocks and Natural Products by Matheau-Raven, Daniel, Gabriel, Pablo, Leitch, Jamie A, Almehmadi, Yaseen A, Yamazaki, Ken, Dixon, Darren J

“…The tertiary amide is a ubiquitous functional group and plays an irreplaceable role in medicinal chemistry. Its robust nature has meantin the pastthat…”
Get full text

Continuous flow mechanochemistry: reactive extrusion as an enabling technology in organic synthesis by Bolt, Robert R A, Leitch, Jamie A, Jones, Andrew C, Nicholson, William I, Browne, Duncan L

“…Rapid and wide-ranging developments have established mechanochemistry as a powerful avenue in sustainable organic synthesis. This is primarily due to unique…”
Get more information

Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial by Giuliano, Armando E, McCall, Linda, Beitsch, Peter, Whitworth, Pat W, Blumencranz, Peter, Leitch, A Marilyn, Saha, Sukamal, Hunt, Kelly K, Morrow, Monica, Ballman, Karla

“…Sentinel lymph node dissection (SLND) has eliminated the need for axillary dissection (ALND) in patients whose sentinel node (SN) is tumor-free. However,…”
Get full text

Association of Occult Metastases in Sentinel Lymph Nodes and Bone Marrow With Survival Among Women With Early-Stage Invasive Breast Cancer by Giuliano, Armando E, Hawes, Debra, Ballman, Karla V, Whitworth, Pat W, Blumencranz, Peter W, Reintgen, Douglas S, Morrow, Monica, Leitch, A. Marilyn, Hunt, Kelly K, McCall, Linda M, Abati, Andrea, Cote, Richard

“…CONTEXT Immunochemical staining of sentinel lymph nodes (SLNs) and bone marrow identifies breast cancer metastases not seen with routine pathological or…”
Get full text

Axillary Dissection vs No Axillary Dissection in Women With Invasive Breast Cancer and Sentinel Node Metastasis: A Randomized Clinical Trial by Giuliano, Armando E, Hunt, Kelly K, Ballman, Karla V, Beitsch, Peter D, Whitworth, Pat W, Blumencranz, Peter W, Leitch, A. Marilyn, Saha, Sukamal, McCall, Linda M, Morrow, Monica

“…CONTEXT Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal…”
Get full text

Tumor Biology Correlates With Rates of Breast-Conserving Surgery and Pathologic Complete Response After Neoadjuvant Chemotherapy for Breast Cancer: Findings From the ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial by Boughey, Judy C, McCall, Linda M, Ballman, Karla V, Mittendorf, Elizabeth A, Ahrendt, Gretchen M, Wilke, Lee G, Taback, Bret, Leitch, A Marilyn, Flippo-Morton, Teresa, Hunt, Kelly K

“…OBJECTIVE:To determine the impact of tumor biology on rates of breast-conserving surgery and pathologic complete response (pCR) after neoadjuvant chemotherapy…”
Get full text

Temperature‐Controlled Mechanochemistry for the Nickel‐Catalyzed Suzuki–Miyaura‐Type Coupling of Aryl Sulfamates via Ball Milling and Twin‐Screw Extrusion. by Bolt, Robert R. A., Raby‐Buck, Sarah E., Ingram, Katharine, Leitch, Jamie A., Browne, Duncan L.

“…The use of temperature‐controlled mechanochemistry to enable the mechanochemical nickel‐catalyzed Suzuki–Miyaura coupling is herein described. Transitioning…”
Get full text

Ruthenium‐Catalyzed para‐Selective C−H Alkylation of Aniline Derivatives by Leitch, Jamie A., McMullin, Claire L., Paterson, Andrew J., Mahon, Mary F., Bhonoah, Yunas, Frost, Christopher G.

“…The para‐selective C−H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via…”
Get full text

Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer: The ACOSOG Z1071 (Alliance) Clinical Trial by Boughey, Judy C, Suman, Vera J, Mittendorf, Elizabeth A, Ahrendt, Gretchen M, Wilke, Lee G, Taback, Bret, Leitch, A. Marilyn, Kuerer, Henry M, Bowling, Monet, Flippo-Morton, Teresa S, Byrd, David R, Ollila, David W, Julian, Thomas B, McLaughlin, Sarah A, McCall, Linda, Symmans, W. Fraser, Le-Petross, Huong T, Haffty, Bruce G, Buchholz, Thomas A, Nelson, Heidi, Hunt, Kelly K

“…IMPORTANCE Sentinel lymph node (SLN) surgery provides reliable nodal staging information with less morbidity than axillary lymph node dissection (ALND) for…”
Get full text

Reverse Polarity Reductive Functionalization of Tertiary Amides via a Dual Iridium-Catalyzed Hydrosilylation and Single Electron Transfer Strategy by Rogova, Tatiana, Gabriel, Pablo, Zavitsanou, Stamatia, Leitch, Jamie A, Duarte, Fernanda, Dixon, Darren J

“…A strategy for the mild generation of synthetically valuable α-amino radicals from robust tertiary amide building blocks has been developed. By combining…”
Get full text

Fluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2 -positive breast cancer (Z1041): a randomised, controlled, phase 3 trial by Buzdar, Aman U, Prof, Suman, Vera J, Prof, Meric-Bernstam, Funda, Prof, Leitch, A Marilyn, Prof, Ellis, Matthew J, Prof, Boughey, Judy C, MD, Unzeitig, Gary, MD, Royce, Melanie, Prof, McCall, Linda M, MS, Ewer, Michael S, Prof, Hunt, Kelly K, Prof

“…Summary Background Neoadjuvant chemotherapy with trastuzumab for patients with HER2 -positive breast cancer can produce a pathological complete response in the…”
Get full text

Magma Mushes of the Fogo Island Batholith: a Study of Magmatic Processes at Multiple Scales by Graham, B, Dunning, G, Leitch, A M

“…Abstract This field, petrographic, and geochemical study examines mingling of compositionally similar rocks at multiple scales. Evidence of complex magma…”
Get full text

Nicotine in floral nectar pharmacologically influences bumblebee learning of floral features by Baracchi, D., Marples, A., Jenkins, A. J., Leitch, A. R., Chittka, L.

“…Many plants defend themselves against herbivores by chemical deterrents in their tissues and the presence of such substances in floral nectar means that…”
Get full text