Search Results - "Leitão, Maria"

Properties of Therapeutic Deep Eutectic Solvents of l-Arginine and Ethambutol for Tuberculosis Treatment by Santos, Filipa, P S Leitão, Maria Inês, C Duarte, Ana Rita

“…The treatment for tuberculosis infection usually involves a prolonged regimen of multiple antibacterial drugs, which might lead to various secondary effects…”
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Antitumor Activity and Reductive Stress by Platinum(II) N‐Heterocyclic Carbenes based on Guanosine by Leitão, Maria Inês P. S., Turos‐Cabal, Maria, Sanchez‐Sanchez, Ana Maria, Gomes, Clara S. B., Herrera, Federico, Martin, Vanesa, Petronilho, Ana

“…Platinum(II) complexes bearing N‐heterocyclic carbenes based guanosine and caffeine have been synthesized by unassisted C−H oxidative addition, leading to the…”
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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies by Leitão, Maria Inês P. S., Morais, Tânia S.

“…Innovative strategies for targeted anticancer therapies have gained significant momentum, with metal complexes emerging as tunable catalysts for more effective…”
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Synthesis of Platinum(II) N-Heterocyclic Carbenes Based on Adenosine by Leitão, Maria Inês P. S., Francescato, Giulia, Gomes, Clara S. B., Petronilho, Ana

“…Organometallic derivatization of nucleosides is a highly promising strategy for the improvement of the therapeutic profile of nucleosides. Herein, a…”
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Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1 by de Alencar, Daniel Machado, Gonçalves, Juliana, Vieira, Andreia, Cerqueira, Sofia A, Sebastião, Cruz, Leitão, Maria Inês P S, Francescato, Giulia, Antenori, Paola, Soares, Helena, Petronilho, Ana

“…We report herein a set of 3'-azido-3'-deoxythymidine (AZT) derivatives based on triazoles and triazolium salts for HIV-1 infection. The compounds were…”
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Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer's disease by Leitão, Maria João, Silva-Spínola, Anuschka, Santana, Isabel, Olmedo, Veronica, Nadal, Alicia, Le Bastard, Nathalie, Baldeiras, Inês

“…Ongoing efforts within the Alzheimer's disease (AD) field have focused on improving the intra- and inter-laboratory variability for cerebrospinal fluid (CSF)…”
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Nickel N‐heterocyclic carbene complexes based on xanthines: Synthesis and antifungal activity on Candida sp by Francescato, Giulia, Silva, Sofia M. da, Leitão, Maria Inês P. S., Gaspar‐Cordeiro, Ana, Giannopoulos, Nikolaos, Gomes, Clara S. B., Pimentel, Catarina, Petronilho, Ana

“…Invasive fungal diseases affect more than two million people worldwide. The increasing incidence of invasive fungal infections is the result of many factors,…”
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Blood biomarkers in mild cognitive impairment patients: Relationship between analytes and progression to Alzheimer disease dementia by Silva‐Spínola, Anuschka, Lima, Marisa, Leitão, Maria João, Bernardes, Catarina, Durães, João, Duro, Diana, Tábuas‐Pereira, Miguel, Santana, Isabel, Baldeiras, Inês

“…Background and purpose Blood‐based biomarkers are promising tools for the diagnosis of Alzheimer disease (AD) at prodromal stages (mild cognitive impairment…”
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Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia by Silva‐Spínola, Anuschka, Lima, Marisa, Leitão, Maria João, Durães, João, Tábuas‐Pereira, Miguel, Almeida, Maria Rosário, Santana, Isabel, Baldeiras, Inês

“…Background and purpose Neurofilament light chain (NfL) has recently been proposed as a promising biomarker in frontotemporal dementia (FTD). We investigated…”
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C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia by Fernandes, Andreia, Tábuas-Pereira, Miguel, Duro, Diana, Lima, Marisa, Gens, Helena, Santiago, Beatriz, Durães, João, Almeida, Maria Rosário, Leitão, Maria João, Baldeiras, Inês, Santana, Isabel

“…Increasing evidence suggests that inflammation plays an important role in brain aging and neurodegeneration. Pathological studies demonstrate the presence of…”
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Molecular targets of HPV oncoproteins: Potential biomarkers for cervical carcinogenesis by de Freitas, Antonio Carlos, Coimbra, Eliane Campos, Leitão, Maria da Conceição Gomes

“…Cervical cancer is the second most common cancer among women worldwide and is responsible for 275,000 deaths each year. Persistent infection with high-risk…”
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Exploring the potential of fully automated LUMIPULSE G plasma assays for detecting Alzheimer's disease pathology by Silva-Spínola, Anuschka, Leitão, Maria João, Nadal, Alicia, Le Bastard, Nathalie, Santana, Isabel, Baldeiras, Inês

“…LUMIPULSE G-automated immunoassays represent a widely used method for the quantification of Alzheimer's disease (AD) biomarkers in the cerebrospinal fluid…”
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The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study by Ximenes, Jorge Luiz Saraiva, Rocha-Filho, Joel Avancini, Galvão, Flavio Henrique Ferreira, Lanchotte, Cinthia, Kubrusly, Marcia Saldanha, Leitão, Regina Maria Cubero, Jukemura, Jose, Moscoso, Agustin Vintimilla, Abdo, Emilio Elias, D'Albuquerque, Luiz Augusto Carneiro, Figueira, Estela Regina Ramos

“…Liver ischaemia-reperfusion (IR) during hepatic surgeries can lead to liver cell death via oxidative stress and the activation of immune cells, the release of…”
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Neuroprotective effect of blackberry (Rubus sp.) polyphenols is potentiated after simulated gastrointestinal digestion by Tavares, Lucélia, Figueira, Inês, Macedo, Diana, McDougall, Gordon J., Leitão, Maria Cristina, Vieira, Helena L.A., Stewart, Derek, Alves, Paula M., Ferreira, Ricardo B., Santos, Cláudia N.

“…► We evaluated undigested and in vitro digested blackberry metabolites. ► Blackberry digested in vitro showed different phenolic composition. ► Physiological…”
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Domestic Violence Victimization Risk Assessment in Children and Adolescents: A Systematic Review by Cunha, Daniela Rita Ribeiro, Leitão, Maria Emília, Sani, Ana Isabel

“…Background: Risk assessment is the process of collecting information towards the goal of protecting the physical and psychological integrity of the victim,…”
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Benzo[a]phenoxazinium chlorides: Synthesis, antifungal activity, in silico studies and evaluation as fluorescent probes by Leitão, Maria Inês P.S., Rama Raju, B., Cerqueira, Nuno M.F.S.A., Sousa, Maria João, Gonçalves, M. Sameiro T.

“…[Display omitted] •New benzo[a]phenoxazinium salts with chloride, ester and methyl as terminals were synthesized.•The antiproliferative activity with others…”
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Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease by Tábuas-Pereira, Miguel, Durães, João, Lopes, Joana, Sales, Francisco, Bento, Conceição, Duro, Diana, Santiago, Beatriz, Almeida, Maria Rosário, Leitão, Maria João, Baldeiras, Inês, Santana, Isabel

“…Neurofibrillary tangles and tau protein, the neuropathological hallmarks of Alzheimer's disease (AD), have been identified in patients with epilepsy. Tau…”
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Reduced Expression of IL-1β and IL-18 Proinflammatory Interleukins Increases the Risk of Developing Cervical Cancer by Matamoros, Jose Anibal, da Silva, Maria Isabel Ferreira, de Moura, Patrícia Muniz Mendes Freire, Leitão, Maria da Conceição Gomes, Coimbra, Eliane Campos

“…Background: The objective of this study was to analyze the gene expression profile of the proinflammatory interleukins, (IL-1β and IL-18) in patients with…”
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HEAVY METAL-INDUCED OXIDATIVE STRESS IN ALGAE by Pinto, Ernani, Sigaud-kutner, Teresa C. S., Leitão, Maria A. S., Okamoto, Oswaldo K., Morse, David, Colepicolo, Pio

“…Heavy metals, depending on their oxidation states, can be highly reactive and, as a consequence, toxic to most organisms. They are produced by an expanding…”
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Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors by Tábuas-Pereira, Miguel, Baldeiras, Inês, Duro, Diana, Santiago, Beatriz, Ribeiro, Maria Helena, Leitão, Maria João, Oliveira, Catarina, Santana, Isabel

“…Despite having the same histopathological characteristics, early-onset and late-onset Alzheimer's disease (AD) patients show some distinct clinical and…”
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