Search Results - "Leit, S."

Direct Synthesis of Previously Inaccessible Bridgehead Azabicyclics by Intramolecular Cyclization of α-Sulfonamido and α-Sulfonimido Radicals by Paquette, Leo A., Ra, Choon Sup, Schloss, Jeffrey D., Leit, Silvana M., Gallucci, Judith C.

“…Syntheses of the first bridgehead sultams and the only known bridgehead disulfonimide are described. Both approaches capitalize on the electrophilicity of…”
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356 (PB344): Preclinical characterization of NTX-452, a potent, selective and highly efficacious WRN inhibitor for the treatment of MSI-H tumors by Boiko, S., Li, D., Toms, A., Caravella, J., Carreiro, S., Bartels, F., Sitnikov, N., Browning, B., Leit, S., Jacques-O’Hagan, S., Oh, H., Florine, E., Li, Z., Scheuber, A., Phadke, A., Khong, Y.M., Britt, S., Alexander, J., Tummino, P., Svensson, R.

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Radical and Anionic Response of N-(Bromomethanesulfonyl)-Substituted α,α‘-Bridged Piperidine Substrates by Schloss, Jeffrey D, Leit, Silvana M, Paquette, Leo A

“…The N-(bromomethanesulfonyl) azabicyclic ketones 2a−c and their ex o-methylene analogues 1a−c were prepared. Our examination of the radical-induced behavior of…”
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Osteoclasts culture in compartmantalized microfluidic platforms and bone-like mineralized substrates by Estrela, Neto, Diogo, Carvalho, Daniela, Sousa, Francisco, Concei o, Lu s, Leit o, Meriem, Lamghari

“…Abstract only…”
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Outpatient vs. home-based pulmonary rehabilitation in COPD: a randomized controlled trial by Mendes de Oliveira, Júlio C, Studart Leitão Filho, Fernando S, Malosa Sampaio, Luciana M, Negrinho de Oliveira, Ana C, Hirata, Raquel Pastrello, Costa, Dirceu, Donner, Claudio F, de Oliveira, Luís Vf

“…Chronic obstructive pulmonary disease (COPD) is a common cause of morbidity and mortality affecting a large number of individuals in both developed and…”
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Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors by FOURNEL, Marielle, TRACHY-BOURGET, Marie-Claude, DELORME, Daniel, MACLEOD, A. Robert, BESTERMAN, Jeffrey M, ZUOMEI LI, YAN, P. Theresa, KALITA, Ann, BONFILS, Claire, BEAULIEU, Carole, FRECHETTE, Sylvie, LEIT, Silvana, ABOU-KHALIL, Elie, WOO, Soon-Hyung

“…Inhibition of histone deacetylases (HDACs) is emerging as a new strategy in human cancer therapy. We have designed and synthesized novel nonhydroxamate…”
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Structurally Simple Trichostatin A-Like Straight Chain Hydroxamates as Potent Histone Deacetylase Inhibitors by Woo, Soon Hyung, Frechette, Sylvie, Khalil, Elie Abou, Bouchain, Giliane, Vaisburg, Arkadii, Bernstein, Naomy, Moradei, Oscar, Leit, Silvana, Allan, Martin, Fournel, Marielle, Trachy-Bourget, Marie-Claude, Li, Zuomei, Besterman, Jeffrey M, Delorme, Daniel

“…A series of new, structurally simple trichostatin A (TSA)-like straight chain hydroxamates were prepared and evaluated for their ability to inhibit partially…”
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Development of Potential Antitumor Agents. Synthesis and Biological Evaluation of a New Set of Sulfonamide Derivatives as Histone Deacetylase Inhibitors by Bouchain, Giliane, Leit, Silvana, Frechette, Sylvie, Khalil, Elie Abou, Lavoie, Rico, Moradei, Oscar, Woo, Soon Hyung, Fournel, Marielle, Yan, Pu T, Kalita, Ann, Trachy-Bourget, Marie-Claude, Beaulieu, Carole, Li, Zuomei, Robert, Marie-France, MacLeod, A. Robert, Besterman, Jeffrey M, Delorme, Daniel

“…A series of sulfonamide hydroxamic acids and anilides have been synthesized and studied as histone deacetylase (HDAC) inhibitors that can induce…”
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Design and synthesis of a novel class of histone deacetylase inhibitors by Lavoie, Rico, Bouchain, Giliane, Frechette, Sylvie, Woo, Soon Hyung, Khalil, Elie Abou, Leit, Silvana, Fournel, Marielle, Yan, Pu T., Trachy-Bourget, Marie-Claude, Beaulieu, Carole, Li, Zuomei, Besterman, Jeffrey, Delorme, Daniel

“…Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series…”
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Discovery and Development of Novel HDAC Inhibitors for Huntington’s Disease by Patzke, H., Chesworth, R., Li, Z., Rahil, G., Wang, J., Smith, J., Huet, F.L., Shapiro, G., Leit, S., Beaulieu, P., Raeppel, F., Fournel, M., Sainte-Croix, H., Nolan, S.J., Albayya, F.P., Barbier, A., Besterman, J., Ahlijanian, M.K., Deziel, R.

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(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors by Vaisburg, Arkadii, Bernstein, Naomy, Frechette, Sylvie, Allan, Martin, Abou-Khalil, Elie, Leit, Silvana, Moradei, Oscar, Bouchain, Giliane, Wang, James, Woo, Soon Hyung, Fournel, Marielle, Yan, Pu T., Trachy-Bourget, Marie-Claude, Kalita, Ann, Beaulieu, Carole, Li, Zuomei, MacLeod, A.Robert, Besterman, Jeffrey M., Delorme, Daniel

“…A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone…”
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Inaugural Huntington Disease Clinical Research Symposium Organized by the Huntington Study Group by Ross, C. A., Beglinger, L. J., Tomusk, A., Lifer, S., Hastings, S., Dawson, J., Walker, B., Whitlock, K., Johnson, S., Pacifici, Robert, Hersch, S., Katz, Russell, Wheelock, V., Schwartz, G., Mattis, P., Young, P., McArthur, D. L., Chirieac, M. C., Shinaman, A., Shoulson, I., Kane, A. E., Peavy, G. M., Jacobson, M. W., Wasserman, L., Tang, C., Zgaljardic, D., Ma, Y., Dhawan, V., Guttman, M., Eidelberg, D., Peng, S., Rosas, H. D., Gevorkian, S., Oakes, D., Latourelle, J., Fossale, E., Gillis, T., Gusella, J. F., MacDonald, M. E., Myers, R. H., Yastrubetskaya, O., Chiu, E., Goh, A., Kayson, E., Quaid, K., Sims, S., Swenson, M., Harrison, J., Moskowitz, C., Stepanov, N., Suter, G., Johnson, S. A., Nopoulos, P., Beglinger, L., Pierson, R., Lipe, H., Bird, T. D., McCusker, E. A., Lechich, A. J., Duckett, A., Klager, J., Sandler, S., Pae, A., Apostol, B. L., Zuccato, C., Illes, K., Marsh, J. L., Thompson, L. Michels, Patzke, H., Chesworth, R., Li, Z., Rahil, G., Shapiro, G., Leit, S., Beaulieu, P., Fournel, M., Barbier, A., Besterman, J., Deziel, R., Aubeeluck, A., Ross, C., Landwehrmeyer, B., Whitlock, K. B., Lee, J., Kim, R. Y., Cahill, T., Johnson, D., Jacobson, M., Goodman, L. Veatch, Cha, J. H., Adams, M., de Blieck, E. A., McCallum, C., Clarke, A., Stewart, R., Adams, W. H., Paulson, H., Hanson, J. M., Priller, J., Ecker, D.

“…Issue Title: Movement Disorders…”
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The First Examples of Bridgehead Bicyclic Sultams by Paquette, Leo A, Leit, Silvana M

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Intramolecular Cyclization of Radicals Generated from α-Halomethylsulfonamides by Leit, Silvana M, Paquette, Leo A

“…A series of homologous α-sulfonamidyl radicals has been generated by reaction of α-halomethyl precursors with tri-n-butyltin hydride under AIBN catalysis. The…”
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The planktonic rotifers of the estuarine lagunar complex of Suape (Pernambuco, Brazil) by NEUMANN-LEITAO, S, PARANUGUA, M. N, VALENTIN, J. L

“…We studied spatial and temporal distribution, abundance, diversity, equitability and species associations of the rotifers of the estuarine area of Suape…”
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Development of a two stage virtual impactor for stationary source PM10 and PM2.5 sampling by Jiang, Jing-Kun, Deng, Jian-Guon, Duan, Leit, Zhang, Qiang, Li, Zhen, Chen, Xiao-Tong, Li, Xing-Hua, Hao, Ji-Ming

“…China does not have a national standard method for stationary source PM10 and PM2.5 sampling. Current commercial PM10/PM2.5 samplers have some limitations when…”
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