Search Results - "Leistner, Adrian"

Analytical Quality by Design: Achieving Robustness of an LC-CAD Method for the Analysis of Non-Volatile Fatty Acids by Walther, Rasmus, Krmar, Jovana, Leistner, Adrian, Svrkota, Bojana, Otašević, Biljana, Malenović, Andjelija, Holzgrabe, Ulrike, Protić, Ana

“…An alternative to the time-consuming and error-prone pharmacopoeial gas chromatography method for the analysis of fatty acids (FAs) is urgently needed. The…”
Get full text

Charged aerosol detector response modeling for fatty acids based on experimental settings and molecular features: a machine learning approach by Pawellek, Ruben, Krmar, Jovana, Leistner, Adrian, Djajić, Nevena, Otašević, Biljana, Protić, Ana, Holzgrabe, Ulrike

“…The charged aerosol detector (CAD) is the latest representative of aerosol-based detectors that generate a response independent of the analytes’ chemical…”
Get full text

Alternative methods to assess the impurity profile of a monographed API using acarbose as an example by Leistner, Adrian, Holzgrabe, Ulrike

“…Even though the impurity analysis of the Ph. Eur. is considered well-studied, its methodology should be reviewed periodically to ensure that it is working…”
Get full text

Impurity profiling of dapsone using gradient HPLC method by Leistner, Adrian, Holzgrabe, Ulrike

“…•Development and validation of a HPLC method for the impurity control of dapsone.•Replacement of the TLC related substances test by HPLC…”
Get full text

Impurity Profiling of Baclofen Using Gradient HPLC–UV Method by Leistner, Adrian, Holzgrabe, Ulrike

“…The GABA B receptor agonist baclofen is a medication commonly used for the treatment of muscle spasticity. It is an amino acid and related to the…”
Get full text

Risk assessment report of potential impurities in cetirizine dihydrochloride by Leistner, Adrian, Haerling, Stephan, Kreher, Joerg-Detlef, Becker, Ivonne, Jung, Dirk, Holzgrabe, Ulrike

“…•Implementation of an assessment for unexpected impurities arising in drug synthesis.•Different ways impurities of Cetirizine dihydrochloride can arise are…”
Get full text