Search Results - "Leist, TP"

Familial Multiple Sclerosis and Other Inherited Disorders of the White Matter by Kalman, Bernadette, Leist, Thomas P.

“…BACKGROUND:An objective demonstration of lesions disseminated in time and space remains the core of the last revision of diagnostic criteria for multiple…”
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Pooled safety and tolerability data from four placebo-controlled teriflunomide studies and extensions by Comi, Giancarlo, Freedman, Mark S, Kappos, Ludwig, Olsson, Tomas P, Miller, Aaron E, Wolinsky, Jerry S, O'Connor, Paul W, Benamor, Myriam, Dukovic, Deborah, Truffinet, Philippe, Leist, Thomas P

“…Abstract Background Teriflunomide, a once-daily oral immunomodulator for the treatment of relapsing-remitting multiple sclerosis, has demonstrated consistent…”
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Long-term safety and efficacy of dalfampridine for walking impairment in patients with multiple sclerosis: Results of open-label extensions of two Phase 3 clinical trials by Goodman, Andrew D, Bethoux, Francois, Brown, Theodore R, Schapiro, Randall T, Cohen, Ron, Marinucci, Lawrence N, Henney, Herbert R, Blight, Andrew R, Agius, M, Arnason, BGW, Bethoux, FA, Bever, CT, Bowen, JD, Brown, TR, Dietrich, DW, Edwards, K, Freedman, MS, Freedman, M, Kachuck, NJ, Kaufman, MD, Keilson, M, Khan, O, Krupp, LB, Leist, TP, Lindsey, JW, Lublin, FD, Mass, MK, Mattson, D, McGowan, D, Naismith, R, O’Connell, C, Oger, JJ, Panitch, H, Picone, MA, Rammohan, KW, Schapiro, RT, Schwid, SR, Scott, T, Short, C, Thrower, BW, Vollmer, TL, Camac, A, Cooper, JA, Chumley, WF, Cross, A, Dunnigan, RT, Gitt, JS, Hillen, M, Jeffrey, DR, Khatri, BO, Kresa-Reahl, K, Moon, S, Preiningerova, J, Tullman, M, Weinstock-Guttman, B, Wynn, DR

“…Background: In Phase 3 double-blind trials (MS-F203 and MS-F204), dalfampridine extended release tablets 10 mg twice daily (dalfampridine-ER; prolonged-release…”
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Clinical-Magnetic Resonance Imaging Correlations in Multiple Sclerosis by Zivadinov, Robert, Leist, Thomas P.

“…ABSTRACT Conventional magnetic resonance imaging (MRI) has routinely been used to improve the accuracy of multiple sclerosis (MS) diagnosis and monitoring,…”
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“Number Needed to treat” analysis to Assess the comparative outcomes from Teriflunomide and dimethyl fumarate studies in relapsing multiple sclerosis by Leist, TP, Montalban, X, Miller, AE, Dive-Pouletty, C, Freedman, MS

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PND13 - “Number Needed to treat” analysis to Assess the comparative outcomes from Teriflunomide and dimethyl fumarate studies in relapsing multiple sclerosis by Leist, TP, Montalban, X, Miller, AE, Dive-Pouletty, C, Freedman, MS

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Interferon- beta 1a therapy in human T-lymphotropic virus type I-associated neurologic disease by Oh, Unsong, Yamano, Yoshihisa, Mora, Carlos A, Ohayon, Joan, Bagnato, Francesca, Butman, John A, Dambrosia, James, Leist, Thomas P, McFarland, Henry, Jacobson, Steven

“…Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an immune-mediated inflammatory disorder of the…”
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Increased Activated Human T Cell Lymphotropic Virus Type I (HTLV-I) Tax11-19-Specific Memory and Effector CD8+ Cells in Patients with HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis: Correlation with HTLV-I Provirus Load by Nagai, Masahiro, Kubota, Ryuji, Greten, Tim F., Schneck, Jonathan P., Leist, Thomas P., Jacobson, Steven

“…To discern the T cell subtype associated with T cell differentiation, the expression of CD45RA and CD27 was measured from total CD8high cells and from human T…”
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Direct Visualization of Antigen-Specific T Cells: HTLV-1 Tax11-19-Specific CD8+T Cells are Activated in Peripheral Blood and Accumulate in Cerebrospinal Fluid from HAM/TSP Patients by Greten, Tim F., Slansky, Jill E., Kubota, Ryuji, Soldan, Samantha S., Jaffee, Elizabeth M., Leist, Thomas P., Pardoll, Drew M., Jacobson, Steven, Schneck, Jonathan P.

“…Human T lymphotropic virus type 1 (HTLV-1) -associated myelopathy/tropic spastic paraparesis is a demyelinating inflammatory neurologic disease associated with…”
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Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients by Soldan, Samantha S., Leist, Thomas P., Juhng, K. Newton, McFarland, Henry F., Jacobson, Steven

“…Several reports have suggested an association of human herpevirus 6 (HHV‐6) and multiple sclerosis (MS) based on immunohistochemical demonstration of HHV‐6 DNA…”
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Enhancing magnetic resonance imaging lesions and cerebral atrophy in patients with relapsing multiple sclerosis by Leist, T P, Gobbini, M I, Frank, J A, McFarland, H F

“…To examine the relation between the frequency of enhancing magnetic resonance imaging lesions and their characteristics of enhancement and atrophy in patients…”
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A mitochondrial component of neurodegeneration in multiple sclerosis by Kalman, Bernadette, Leist, Thomas P

“…Neurodegeneration is the main pathological correlate of accumulating disability in progressive stages of Multiple Sclerosis (MS), but both histologic and…”
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Genetic variants of Complex I in multiple sclerosis by Vyshkina, Tamara, Banisor, Ileana, Shugart, Yin Yao, Leist, Thomas P., Kalman, Bernadette

“…A mitochondrial mechanism contributes to neurodegeneration in multiple sclerosis (MS). Genetic variants of Complex I genes may influence the nature of tissue…”
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Interferon beta-1b and intravenous methylprednisolone promote lesion recovery in multiple sclerosis by Richert, N.D., Ostuni, J.L., Bash, C.N., Leist, T.P., McFarland, H.F., Frank, J.A.

“…To determine whether lesion evolution in relapsing-remitting multiple sclerosis (RRMS) patients is altered by treatment with interferonbeta1b (IFNbeta-1b) or…”
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Three Placebo-Controlled Teriflunomide Studies: Pooled Safety Data by Leist, TP, Freedman, MS, Kappos, L, Olsson, TP, Miller, AE, Wolinsky, JS, O'Connor, P, Benamor, M, Truffinet, P, Dukovic, D, Li, J, Comi, G

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Pooled safety analyses from the teriflunomide clinical development program by Leist, TP, Freedman, MS, Kappos, L, Olsson, TP, Miller, AE, Wolinsky, JS, O'Connor, PW, Benamor, M, Truffinet, P, Dukovic, D, Comi, G

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Association of haplotypes in the beta-chemokine locus with multiple sclerosis by Vyshkina, Tamara, Shugart, Yin Yao, Birnbaum, Gary, Leist, Thomas P, Kalman, Bernadette

“…Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data…”
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Longitudinal MRI study: the effects of azathioprine in MS patients refractory to interferon beta-1b by Markovic-Plese, S, Bielekova, B, Kadom, N, Leist, T P, Martin, R, Frank, J A, McFarland, H F

“…An open-label study was performed to assess the effectiveness of oral azathioprine (AZA) on augmenting the response to interferon beta-1b (IFNbeta-1b) in…”
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Progressive necrotizing myelopathy: part of the spectrum of neuromyelitis optica? by Okai, Annette F., Muppidi, Srikanth, Bagla, Ritu, Leist, Thomas P.

“…This case series reviews the clinical, radiographic and laboratory findings of five patients with progressive idiopathic myelopathy with evidence of cord…”
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CD45 (PTPRC) as a candidate gene in multiple sclerosis by Vyshkina, Tamara, Leist, Thomas P, Shugart, Yin Yao, Kalman, Bernadette

“…The 77C→ G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis…”
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