Search Results - "Leiser, Margarita"

Animal Model for Maturity-onset Diabetes of the Young Generated by Disruption of the Mouse Glucokinase Gene (∗) by Bali, Deeksha, Svetlanov, Anton, Lee, Han-Woong, Fusco-DeMane, David, Leiser, Margarita, Li, Baojie, Barzilai, Nir, Surana, Manju, Hou, Harry, Fleischer, Norman, DePinho, Ronald, Rossetti, Luciano, Efrat, Shimon

“…Glucokinase catalyzes a rate-limiting step in glucose metabolism in hepatocytes and pancreatic β cells and is considered the “glucose sensor” for regulation of…”
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Discordant Effects of Glucosamine on Insulin-stimulated Glucose Metabolism and Phosphatidylinositol 3-Kinase Activity by Hawkins, Meredith, Hu, Meizhu, Yu, Jinghua, Eder, Howard, Vuguin, Patricia, She, Li, Barzilai, Nir, Leiser, Margarita, Backer, Jonathan M., Rossetti, Luciano

“…The impact of increased GlcN availability on insulin-stimulated p85/p110 phosphatidylinositol 3-kinase (PI3K) activity in skeletal muscle was examined in…”
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Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass by Gelling, Richard W, Vuguin, Patricia M, Du, Xiu Quan, Cui, Lingguang, Rømer, John, Pederson, Raymond A, Leiser, Margarita, Sørensen, Heidi, Holst, Jens J, Fledelius, Christian, Johansen, Peter B, Fleischer, Norman, McIntosh, Christopher H S, Nishimura, Erica, Charron, Maureen J

“…In addition to its primary role in regulating glucose production from the liver, glucagon has many other actions, reflected by the wide tissue distribution of…”
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Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic β-cells to correct diabetes in allogeneic mice by Kojaoghlanian, T, Joseph, A, Follenzi, A, Zheng, J H, Leiser, M, Fleischer, N, Horwitz, M S, DiLorenzo, T P, Goldstein, H

“…The effectiveness of genetic engineering with lentivectors to protect transplanted cells from allogeneic rejection was examined using, as a model, type 1…”
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Functional analysis of a conditionally transformed pancreatic beta-cell line by FLEISCHER, N, CHUAN CHEN, SURANA, M, LEISER, M, ROSSETTI, L, PRALONG, W, EFRAT, S

“…Functional analysis of a conditionally transformed pancreatic beta-cell line. N Fleischer , C Chen , M Surana , M Leiser , L Rossetti , W Pralong and S Efrat…”
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Clonal insulinoma cell line that stably maintains correct glucose responsiveness by KNAACK, D, FIORE, D. M, MANJU SURANA, LEISER, M, LAURANCE, M, FUSCO-DEMANE, D, HEGRE, O. D, FLEISCHER, N, EFRAT, S

“…A number of pancreatic beta-tumor cell (beta TC) lines have been derived from insulinomas arising in transgenic mice expressing the SV40 T antigen gene under…”
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Murine insulinoma cell line with normal glucose-regulated insulin secretion by EFRAT, S, LEISER, M, SURANA, M, TAL, M, FUSCO-DEMANE, D, FLEISCHER, N

“…Pancreatic beta TC lines derived from insulinomas arising in transgenic mice expressing SV40 Tag under control of the insulin promoter manifest a…”
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cAMP-dependent phosphorylation of the cardiac-type alpha 1 subunit of the voltage-dependent Ca2+ channel in a murine pancreatic beta-cell line by Leiser, M, Fleischer, N

“…cAMP-dependent phosphorylation of the cardiac-type alpha 1 subunit of the voltage-dependent Ca2+ channel in a murine pancreatic beta-cell line. M Leiser and N…”
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Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion by Efrat, Shimon, Leiser, Margarita, Y.-Jian Wu, Fusco-DeMane, David, Emran, Obaidullah A., Surana, Manju, Jetton, Thomas L., Magnuson, Mark A., Weir, Gordon, Fleischer, Norman

“…Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in…”
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cAMP-dependent phosphorylation of the cardiac-type α1 subunit of the voltage-dependent Ca2+ channel in a murine pancreatic β-cell line by LEISER, M, FLEISCHER, N

“…Two voltage-dependent calcium channels (VDCCs) have been reported in pancreatic islets: the β-cell/endocrine-brain and cardiac subtypes. The cardiac-type α1…”
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{Val(12)}HRAS downregulates GLUT2 in (beta) cells of transgenic mice without affecting glucose homeostasis by Tal, Michael, Leiser, Margarita, Surana, Manju, Lodish, Harvey

“…Evidence is presented that a pronounced decrease in Beta-cell glucose transporter isotype GLUT2 has no immediate effect on glucose homeostasis. It is suggested…”
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Ribozyme-mediated attenuation of pancreatic (beta)-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion by Efrat, Shimon, Leiser, Margarita, Wu, Y-Jian, Fusco-De Mane, David

“…To generate an animal model for maturity-onset diabetes of the young (MODY), a glucokinase (GK) antisense RNA with a ribozyme element under control of the…”
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[Val12]HRAS Downregulates GLUT2 in β Cells of Transgenic Mice without Affecting Glucose Homeostasis by Tal, Michael, Y-Jian Wu, Leiser, Margarita, Surana, Manju, Lodish, Harvey, Fleischer, Norman, Weir, Gordon, Efrat, Shimon

“…Glucose-induced insulin release from pancreatic β cells depends on the β-cell metabolism of glucose, which generates intracellular signals for secretion. The…”
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A study of energy conservation in Rhodospirillum rubrum chromatophores by Leiser, Margarita

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Cyclic AMP turnover and signal amplification: a reply by Leiser, Margarita, Fleischer, Norman, Erlichman, Jack

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Comparison of the electrochemical proton gradient and phosphate potential maintained by Rhodospirillum rubrum chromatophores in the steady state by Leiser, M, Gromet-Elhanan, Z

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Demonstration of acid—base phosphorylation in chromatophores in the presence of a K + diffusion potential by Leiser, Margarita, Gromet-Elhanan, Zippora

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