Search Results - "Leire Arbillaga"

Genotoxicity of Aflatoxin B1 and Ochratoxin A after simultaneous application of the in vivo micronucleus and comet assay by Corcuera, Laura-Ana, Vettorazzi, Ariane, Arbillaga, Leire, Pérez, Noemí, Gil, Ana Gloria, Azqueta, Amaya, González-Peñas, Elena, García-Jalón, Jose Antonio, López de Cerain, Adela

“…Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) are genotoxic mycotoxins that can contaminate a variety of foodstuffs, the liver and the kidney being their target…”
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Coffee and spent coffee extracts protect against cell mutagens and inhibit growth of food-borne pathogen microorganisms by Monente, Carmen, Bravo, Jimena, Vitas, Ana Isabel, Arbillaga, Leire, De Peña, M. Paz, Cid, Concepción

“…•Coffee and spent coffee protect against DNA mutation (mutagenicity Ames Test).•Coffee and spent coffee strongly reduce the action of indirect mutagens (up to…”
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Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG by Azqueta, Amaya, Arbillaga, Leire, López de Cerain, Adela, Collins, Andrew

“…The alkaline comet assay, when employed as a genotoxicity test, has relatively low sensitivity because it fails to detect--at non-cytotoxic…”
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Antioxidant and genoprotective effects of spent coffee extracts in human cells by Bravo, Jimena, Arbillaga, Leire, de Peña, M. Paz, Cid, Concepcion

“…•Spent coffee has antioxidant and genoprotective (comet assay) effects in HeLa cells.•Cell viability (MTT) was not affected by spent coffee extracts (>80%) up…”
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Synthesis and biological evaluation of quinoxaline di-N-oxide derivatives with in vitro trypanocidal activity by Pérez-Silanes, Silvia, Torres, Enrique, Arbillaga, Leire, Varela, Javier, Cerecetto, Hugo, González, Mercedes, Azqueta, Amaya, Moreno-Viguri, Elsa

“…[Display omitted] We report the synthesis and in vitro activity against Trypanosoma cruzi epimastigotes of 15 novel quinoxaline derivatives. Ten of the…”
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Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents by Torres, Enrique, Moreno-Viguri, Elsa, Galiano, Silvia, Devarapally, Goutham, Crawford, Philip W., Azqueta, Amaia, Arbillaga, Leire, Varela, Javier, Birriel, Estefanía, Di Maio, Rossanna, Cerecetto, Hugo, González, Mercedes, Aldana, Ignacio, Monge, Antonio, Pérez-Silanes, Silvia

“…As a continuation of our research and with the aim of obtaining new agents against Chagas disease, an extremely neglected disease which threatens 100 million…”
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The medication discrepancy detection service: A cost-effective multidisciplinary clinical approach by Oñatibia-Astibia, Ainhoa, Malet-Larrea, Amaia, Mendizabal, Amaia, Valverde, Elena, Larrañaga, Belen, Gastelurrutia, Miguel Ángel, Ezcurra, Martín, Arbillaga, Leire, Calvo, Begoña, Goyenechea, Estibaliz

“…To estimate the effectiveness of a Medication Discrepancy Detection Service (MDDS), a collaborative service between the community pharmacy and Primary Care…”
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Non-clinical toxicity studies on bioactive compounds within the framework of nutritional and health claims by Gil, Ana Gloria, Arbillaga, Leire, López de Cerain, Adela

“…The growing presence of products on the market with added value in terms of health makes essential their regulation and harmonization in critical aspects such…”
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Kidney and liver distribution of ochratoxin A in male and female F344 rats by Vettorazzi, Ariane, de Trocóniz, Iñaki Fernández, González-Peñas, Elena, Arbillaga, Leire, Corcuera, Laura-Ana, Gil, Ana Gloria, de Cerain, Adela López

“…► OTA levels in kidney and liver after one or repeated oral doses to F344 rats both sexes. ► Concentrations very similar between both organs. ► Distribution…”
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Defining and characterising age‐friendly community pharmacies: a qualitative study by Malet‐Larrea, Amaia, Arbillaga, Leire, Gastelurrutia, Miguel Á., Larrañaga, Belén, Garay, Ángel, Benrimoj, Shalom I., Oñatibia‐Astibia, Ainhoa, Goyenechea, Estíbaliz

“…Introduction The Global Network of Age‐friendly Cities is a project promoted by the World Health Organization as a response to demographic ageing and…”
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Oxidative DNA damage induced by Ochratoxin A in the HK-2 human kidney cell line: evidence of the relationship with cytotoxicity by Arbillaga, Leire, Azqueta, Amaia, Ezpeleta, Olga, Cerain, Adela López de

“…Ochratoxin A (OTA) is a mycotoxin produced by species of the genera Aspergillus and Penicillium. The kidneys are the target organ of this mycotoxin and it is…”
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DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide by Junnotula, Venkatraman, Rajapakse, Anuruddha, Arbillaga, Leire, López de Cerain, Adela, Solano, Beatriz, Villar, Raquel, Monge, Antonio, Gates, Kent S.

“…The heterocyclic N-oxide, 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, 1), shows promising antitumor activity in preclinical studies, but there is a…”
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Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration by Arbillaga, Leire, Vettorazzi, Ariane, Gil, Ana G, van Delft, Joost HM, García-Jalón, José Antonio, López de Cerain, Adela

“…Ochratoxin A (OTA), a naturally occurring mycotoxin, is nephrotoxic in all animal species tested and is considered a potent renal carcinogen, particularly in…”
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In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A by Arbillaga, Leire, Azqueta, Amaia, van Delft, Joost H.M., López de Cerain, Adela

“…Ochratoxin A (OTA) is a mycotoxin often found in cereals and agricultural products. There is unequivocal evidence of renal carcinogenicity of OTA in male rats,…”
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The medication discrepancy detection service: A cost-effective multidisciplinary clinical approach by Ainhoa Oñatibia-Astibia, Amaia Malet-Larrea, Amaia Mendizabal, Elena Valverde, Belen Larrañaga, Miguel Ángel Gastelurrutia, Martín Ezcurra, Leire Arbillaga, Begoña Calvo, Estibaliz Goyenechea

“…Objective: To estimate the effectiveness of a Medication Discrepancy Detection Service (MDDS), a collaborative service between the community pharmacy and…”
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Simple high-performance liquid chromatography—fluorescence detection method for plasma, kidney and liver of rat as a tool for toxicology studies by Vettorazzi, Ariane, Gonzalez-Peñas, Elena, Arbillaga, Leire, Corcuera, Laura-Ana, López de Cerain, Adela

“…A fast and simple HPLC-FLD (high-performance liquid chromatography-fluorescence detection) analytical method has been developed and validated for the…”
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A quinoxaline 1,4-di- N-oxide derivative induces DNA oxidative damage not attenuated by vitamin C and E treatment by Azqueta, Amaia, Arbillaga, Leire, Pachón, Gisela, Cascante, Marta, Creppy, Edmond E, Cerain, Adela López de

“…Some anticancer compounds are pro-drugs which give rise to toxic species through enzymatic reduction. The quinoxaline-di- N-oxide derivative Q-85 HCl…”
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Validation of an Antiviral Assay Method for Quantifying Ifn-α5 Activity in Macaque and Human Serum by Arbillaga, Leire, Murillo-Arbizu, Mayte, González, Iranzu, Gil, Ana G, Vettorazzi, Ariane, González-Peñas, Elena, Larrea, Esther, de Cerain, Adela López

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Ochratoxin A-induced renal gene expression changes in F344 rats after repeated oral administration by Arbillaga, Leire, Vettorazzi, Ariane, Gil, Ana G., de Cerain, Adela López

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Influence of the vehicle in the distribution and accumulation of ochratoxin A after oral administration in F-344 rats by Vettorazzi, Ariane, Arbillaga, Leire, Gil, Ana G., González-Peñas, Elena, de Cerain, Adela López

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