Search Results - "Leips, Jeff"

Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression by BUNT, Stephanie K, LINGLIN YANG, SINHA, Pratima, CLEMENTS, Virginia K, LEIPS, Jeff, OSTRAND-ROSENBERG, Suzanne

“…Chronic inflammation is frequently associated with malignant growth and is thought to promote and enhance tumor progression, although the mechanisms which…”
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Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits by Durham, Mary F., Magwire, Michael M., Stone, Eric A., Leips, Jeff

“…Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this…”
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Variable light environments induce plastic spectral tuning by regional opsin coexpression in the African cichlid fish, Metriaclima zebra by Dalton, Brian E., Lu, Jessica, Leips, Jeff, Cronin, Thomas W., Carleton, Karen L.

“…Critical behaviours such as predation and mate choice often depend on vision. Visual systems are sensitive to the spectrum of light in their environment, which…”
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Ancestral ecological regime shapes reaction to food limitation in the Least Killifish, Heterandria formosa by Felmy, Anja, Leips, Jeff, Travis, Joseph

“…Populations with different densities often show genetically based differences in life histories. The divergent life histories could be driven by several agents…”
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Sex-specific responses to simulated territorial intrusions provide evidence for relaxed selection pressure on female song in Orchard Orioles by Moyer, Michelle, Neerchal, Nagaraj, Lohr, Bernard, Leips, Jeff, Osorio, Eriberto, Bare, Ellie, Raza, Aiman, Molake, Bukola, Omland, Kevin

“…Female song has been significantly understudied compared with male song, and our understanding of how this elaborate signal trait may function has been limited…”
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Knockdown expression of Syndecan in the fat body impacts nutrient metabolism and the organismal response to environmental stresses in Drosophila melanogaster by Eveland, Matthew, Brokamp, Gabrielle A., Lue, Chia-Hua, Harbison, Susan T., Leips, Jeff, De Luca, Maria

“…The heparan sulfate proteoglycan syndecans are transmembrane proteins involved in multiple physiological processes, including cell-matrix adhesion and…”
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Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster by Jumbo-Lucioni, Patricia, Ayroles, Julien F, Chambers, Michelle Moses, Jordan, Katherine W, Leips, Jeff, Mackay, Trudy Fc, De Luca, Maria

“…Obesity and phenotypic traits associated with this condition exhibit significant heritability in natural populations of most organisms. While a number of genes…”
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A conserved role for syndecan family members in the regulation of whole-body energy metabolism by De Luca, Maria, Klimentidis, Yann C, Casazza, Krista, Chambers, Michelle Moses, Cho, Ruth, Harbison, Susan T, Jumbo-Lucioni, Patricia, Zhang, Shaoyan, Leips, Jeff, Fernandez, Jose R

“…Syndecans are a family of type-I transmembrane proteins that are involved in cell-matrix adhesion, migration, neuronal development, and inflammation. Previous…”
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Phenotypic Variation and Natural Selection at Catsup, a Pleiotropic Quantitative Trait Gene in Drosophila by Carbone, Mary Anna, Jordan, Katherine W., Lyman, Richard F., Harbison, Susan T., Leips, Jeff, Morgan, Theodore J., DeLuca, Maria, Awadalla, Philip, Mackay, Trudy F.C.

“…Quantitative traits are shaped by networks of pleiotropic genes [1]. To understand the mechanisms that maintain genetic variation for quantitative traits in…”
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High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster by Gurganus, M.C, Nuzhdin, S.V, Leips, J.W, Mackay, T.F.C

“…We have mapped quantitative trait loci (QTL) harboring naturally occurring allelic variation for Drosophila bristle number. Lines with high (H) and low (L)…”
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Pleiotropy, constraint, and modularity in the evolution of life histories: insights from genomic analyses by Hughes, Kimberly A., Leips, Jeff

“…Multicellular organisms display an enormous range of life history (LH) strategies and present an evolutionary conundrum; despite strong natural selection, LH…”
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Phagocytic ability declines with age in adult Drosophila hemocytes by Horn, Lucas, Leips, Jeff, Starz‐Gaiano, Michelle

“…Summary Most multicellular organisms show a physiological decline in immune function with age. However, little is known about the mechanisms underlying these…”
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Using Color to Define Species Boundaries: Quantitative Analysis in the Orchard Oriole Complex Supports the Recognition of two Species by Kiere, Lynna M., Hofmann, Christopher M., Tracy, Ian E., Cronin, Thomas W., Leips, Jeff, Omland, Kevin E.

“…Abstract Abstract. The recent divergence of Orchard (Icterus spurius spurius) and Fuertes's Orioles (I. s. fuertesi) makes them an ideal system for…”
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Large Brains, Small Guts: The Expensive Tissue Hypothesis Supported within Anurans by Liao, Wen Bo, Lou, Shang Ling, Zeng, Yu, Kotrschal, Alexander

“…Brain size differs substantially among species, and several hypotheses have been proposed to explain the evolution of brain size. Because the brain is among…”
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Next Steps in Integrative Biology: Mapping Interactive Processes Across Levels of Biological Organization by Cavigelli, Sonia, Leips, Jeff, Xiang, Qiu-Yun Jenny, Lemke, Dawn, Konow, Nicolai

“…Emergent biological processes result from complex interactions within and across levels of biological organization, ranging from molecular to environmental…”
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Evolution in Population Parameters: Density-Dependent Selection or Density-Dependent Fitness? by Travis, Joseph, Leips, Jeff, Rodd, F. Helen

“…Density-dependent selection is one of earliest topics of joint interest to both ecologists and evolutionary biologists and thus occupies an important position…”
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Coevolutionary Epidemiology: Disease Spread, Local Adaptation, and Sex by Lively, Curtis M.

“…How does evolution in parasite populations affect the rate of disease spread? In the present study, I derived the mean reproductive rate (R̄ 0) for a…”
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GENOMIC BASIS OF AGING AND LIFE-HISTORY EVOLUTION IN DROSOPHILA MELANOGASTER by Remolina, Silvia C., Chang, Peter L., Leips, Jeff, Nuzhdin, Sergey V., Hughes, Kimberly A.

“…Natural diversity in aging and other life-history patterns is a hallmark of organismal variation. Related species, populations, and individuals within…”
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Development and Assessment of Modules to Integrate Quantitative Skills in Introductory Biology Courses by Hoffman, Kathleen, Leupen, Sarah, Dowell, Kathy, Kephart, Kerrie, Leips, Jeff

“…Redesigning undergraduate biology courses to integrate quantitative reasoning and skill development is critical to prepare students for careers in modern…”
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Geographic and Seasonal Variation in Species Diversity and Community Composition of Frugivorous Drosophila (Diptera: Drosophilidae) and their Leptopilina (Hymenoptera: Figitidae) Parasitoids by Lue, Chia-Hua, Borowy, Dorothy, Buffington, Matthew L, Leips, Jeff

“…Many studies have investigated species diversity patterns across space and time, but few have explored patterns of coexistence of tightly interacting species…”
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