Search Results - "Leino, L"

Fecal calcium levels of bird nestlings as a potential indicator of species-specific metal sensitivity by Espín, S., Andersson, T., Haapoja, M., Hyvönen, R., Kluen, E., Kolunen, H., Laaksonen, T., Lakka, J., Leino, L., Merimaa, K., Nurmi, J., Rainio, M., Ruuskanen, S., Rönkä, K., Sánchez-Virosta, P., Suhonen, J., Suorsa, P., Eeva, T.

“…Sensitivity of bird species to environmental metal pollution varies but there is currently no general framework to predict species-specific sensitivity. Such…”
Get full text

Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas) by Ankley, Gerald T., Kuehl, Douglas W., Kahl, Michael D., Jensen, Kathleen M., Linnum, Ann, Leino, Richard L., Villeneuve, Dan A.

“…Perfluorooctanesulfonate (PFOS) is a widespread environmental contaminant emanating from the production and/or metabolism of fluorinated chemicals with a…”
Get full text

Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity by Oliveira, Paulo J., Bjork, James A., Santos, Maria S., Leino, Richard L., Froberg, M.Kent, Moreno, António J., Wallace, Kendall B.

“…The cardiotoxicity associated with doxorubicin (DOX) therapy limits the total cumulative dose and therapeutic success of active anticancer chemotherapy…”
Get full text

Evaluation of the Aromatase Inhibitor Fadrozole in a Short-Term Reproduction Assay with the Fathead Minnow (Pimephales promelas) by Ankley, Gerald T., Kahl, Michael D., Jensen, Kathleen M., Hornung, Michael W., Korte, Joseph J., Makynen, Elizabeth A., Leino, Richard L.

“…Cytochrome P450 aromatase (CYP19) is a key enzyme in vertebrate steroidogenesis, catalyzing the conversion of C19 androgens to C18 estrogens such as…”
Get full text

Cumulative and irreversible cardiac mitochondrial dysfunction induced by doxorubicin by SHAOYU ZHOU, STARKOV, Anatoli, FROBERG, M. Kent, LEINO, Richard L, WALLACE, Kendall B

“…Interference with mitochondrial calcium regulation is proposed to be a primary causative event in the mechanism of doxorubicin-induced cardiotoxicity. We…”
Get full text

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats by Gerhart, D Z, Enerson, B E, Zhdankina, O Y, Leino, R L, Drewes, L R

“…A polyclonal affinity-purified antibody to the carboxyl-terminal end of the rat monocarboxylate transporter 1 (MCT1) was generated in chickens and used in…”
Get full text

Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse by Laihia, J.K., Taimen, P., Kujari, H., Leino, L.

“…Summary Background  cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis. Objectives  We investigated the effects of…”
Get full text

Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain by Leino, Richard L., Gerhart, David Z., Duelli, Roman, Enerson, Bradley E., Drewes, Lester R.

“…Monocarboxylate transporter (MCT1) levels in brains of adult Long–Evans rats on a high-fat (ketogenic) diet were investigated using light and electron…”
Get full text

Carvedilol Protects against Doxorubicin-Induced Mitochondrial Cardiomyopathy by Santos, D.L., Moreno, A.J.M., Leino, R.L., Froberg, M.K., Wallace, K.B.

“…Several cytopathic mechanisms have been suggested to mediate the dose-limiting cumulative and irreversible cardiomyopathy caused by doxorubicin. Recent…”
Get full text

Gonadal histology and characteristic histopathology associated with endocrine disruption in the adult fathead minnow ( Pimephales promelas) by Leino, Richard L., Jensen, Kathleen M., Ankley, Gerald T.

“…Examination of gonadal histopathology has been beneficial in understanding and assessing the effects of potential endocrine disrupting chemicals in fish and…”
Get full text

Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow by Jensen, Kathleen M., Kahl, Michael D., Makynen, Elizabeth A., Korte, Joseph J., Leino, Richard L., Butterworth, Brian C., Ankley, Gerald T.

“…A short-term reproduction assay with the fathead minnow ( Pimephales promelas) has been developed to detect chemicals with the potential to disrupt…”
Get full text

Effects of the androgenic growth promoter 17-β-trenbolone on fecundity and reproductive endocrinology of the fathead minnow by Ankley, Gerald T., Jensen, Kathleen M., Makynen, Elizabeth A., Kahl, Michael D., Korte, Joseph J., Hornung, Michael W., Henry, Tala R., Denny, Jeffrey S., Leino, Richard L., Wilson, Vickie S., Cardon, Mary C., Hartig, Phillip C., Gray, L. Earl

“…Trenbolone acetate is a synthetic steroid that is extensively used in the United States as a growth promoter in beef cattle. The acetate is administered to…”
Get full text

Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro by Viiri, J, Jauhonen, H M, Kauppinen, A, Ryhänen, T, Paimela, T, Hyttinen, J, Sorri, I, Laihia, J K, Leino, L, Kaarniranta, K

“…Urocanic acid (UCA) is a major ultraviolet (UV)-absorbing endogenous chromophore in the epidermis and is also an efficacious immunosuppressant. The…”
Get full text

Effect of cis-urocanic acid on bovine neutrophil generation of reactive oxygen species by Rinaldi, M, Moroni, P, Leino, L, Laihia, J, Paape, M J, Bannerman, D D

“…Neutrophils play a fundamental role in the host innate immune response during mastitis and other bacterial-mediated diseases of cattle. One of the critical…”
Get more information

Expression of the monocarboxylate transporter MCT2 by rat brain glia by Gerhart, David Z., Enerson, Bradley E., Zhdankina, Olga Y., Leino, Richard L., Drewes, Lester R.

“…The nucleotide sequence of the rat monocarboxylate transporter MCT2 was determined from brain‐derived cDNA. A polyclonal antibody was raised in chickens…”
Get full text

Distribution of monocarboxylate transporters MCT1 and MCT2 in rat retina by Gerhart, D.Z., Leino, R.L., Drewes, L.R.

“…Transport of lactic acid and other monocarboxylates such as pyruvate and the ketone bodies through cellular membranes is facilitated by specific transport…”
Get full text

Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study by Leino, Richard L, Gerhart, David Z, Drewes, Lester R

“…Transcellular transport of energy substrates across the vascular endothelial cells of the brain is accomplished by integral membrane carrier proteins, such as…”
Get full text

Evaluation of the methoxytriazine herbicide prometon using a short-term fathead minnow reproduction test and a suite of in vitro bioassays by Villeneuve, Daniel L., Murphy, Margaret B., Kahl, Michael D., Jensen, Kathleen M., Butterworth, Brian C., Makynen, Elizabeth A., Durhan, Elizabeth J., Linnum, Ann, Leino, Richard L., Curtis, Lawrence R., Giesy, John P., Ankley, Gerald T.

“…Prometon is one of the most consistently detected herbicides in the U.S. environment. However, no previous assessment of the potential for prometon or related…”
Get full text

Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17[beta]-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) by Villeneuve, Daniel L, Jensen, Kathleen M, Cavallin, Jenna E, Durhan, Elizabeth J, Garcia-Reyero, Natàlia, Kahl, Michael D, Leino, Richard L, Makynen, Elizabeth A, Wehmas, Leah C, Perkins, Edward J, Ankley, Gerald T

“…Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system…”
Get full text

Effects of the antimicrobial contaminant triclocarban, and co‐exposure with the androgen 17β‐trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) by Villeneuve, Daniel L., Jensen, Kathleen M., Cavallin, Jenna E., Durhan, Elizabeth J., Garcia‐Reyero, Natàlia, Kahl, Michael D., Leino, Richard L., Makynen, Elizabeth A., Wehmas, Leah C., Perkins, Edward J., Ankley, Gerald T.

“…Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system…”
Get full text