Search Results - "Leijten, Jeroen C H"

Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae by Leijten, Jeroen C H, Moreira Teixeira, Liliana S, Landman, Ellie B M, van Blitterswijk, Clemens A, Karperien, Marcel

“…Hypertrophic differentiation of growth plate chondrocytes induces angiogenesis which alleviates hypoxia normally present in cartilage. In the current study, we…”
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Fetal mesenchymal stromal cells differentiating towards chondrocytes acquire a gene expression profile resembling human growth plate cartilage by van Gool, Sandy A, Emons, Joyce A M, Leijten, Jeroen C H, Decker, Eva, Sticht, Carsten, van Houwelingen, Johannes C, Goeman, Jelle J, Kleijburg, Carin, Scherjon, Sicco A, Gretz, Norbert, Wit, Jan Maarten, Rappold, Gudrun, Post, Janine N, Karperien, Marcel

“…We used human fetal bone marrow-derived mesenchymal stromal cells (hfMSCs) differentiating towards chondrocytes as an alternative model for the human growth…”
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Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation by Wu, Ling, Leijten, Jeroen C H, Georgi, Nicole, Post, Janine N, van Blitterswijk, Clemens A, Karperien, Marcel

“…Previous studies showed that coculture of primary chondrocytes (PCs) with various sources of multipotent cells results in a higher relative amount of cartilage…”
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GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors by Leijten, Jeroen C H, Bos, Steffan D, Landman, Ellie B M, Georgi, Nicole, Jahr, Holger, Meulenbelt, Ingrid, Post, Janine N, van Blitterswijk, Clemens A, Karperien, Marcel

“…Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone…”
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Cell sources for articular cartilage repair strategies: shifting from monocultures to cocultures by Leijten, Jeroen C H, Georgi, Nicole, Wu, Ling, van Blitterswijk, Clemens A, Karperien, Marcel

“…The repair of articular cartilage is challenging due to the sparse native cell population combined with the avascular and aneural nature of the tissue. In…”
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Boosting angiogenesis and functional vascularization in injectable dextran-hyaluronic acid hydrogels by endothelial-like mesenchymal stromal cells by Portalska, Karolina Janeczek, Teixeira, Liliana Moreira, Leijten, Jeroen C H, Jin, Rong, van Blitterswijk, Clemens, de Boer, Jan, Karperien, Marcel

“…Angiogenesis and neovascularization are fundamental for the success of clinically relevant-sized tissue-engineered (TE) constructs. The next generation of TE…”
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A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering by Spitters, Tim W G M, Leijten, Jeroen C H, Deus, Filipe D, Costa, Ines B F, van Apeldoorn, Aart A, van Blitterswijk, Clemens A, Karperien, Marcel

“…In cartilage, tissue engineering bioreactors can create a controlled environment to study chondrocyte behavior under mechanical stimulation or produce…”
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Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage by Paggi, Carlo Alberto, Venzac, Bastien, Karperien, Marcel, Leijten, Jeroen C.H., Le Gac, Séverine

“…•Monolithic device with a vertical membrane for mechanical stimulation of tissues.•Actuation unit with 3 individual chambers to apply negative and/or positive…”
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Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells by Zhong, Leilei, Huang, Xiaobin, Rodrigues, Emilie Dooms, Leijten, Jeroen C H, Verrips, Theo, El Khattabi, Mohamed, Karperien, Marcel, Post, Janine N

“…Hypertrophic differentiation occurs during in vitro chondrogenesis of mesenchymal stem cells (MSCs), decreasing the quality of the cartilage construct…”
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The effect of platelet lysate supplementation of a dextran-based hydrogel on cartilage formation by Moreira Teixeira, Liliana S, Leijten, Jeroen C.H, Wennink, Jos W.H, Chatterjea, Anindita G, Feijen, Jan, van Blitterswijk, Clemens A, Dijkstra, Pieter J, Karperien, Marcel

“…Abstract In situ gelating dextran-tyramine (Dex-TA) injectable hydrogels have previously shown promising features for cartilage repair. Yet, despite suitable…”
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In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animal by Higuera, Gustavo A, Hendriks, Jeanine A A, van Dalum, Joost, Wu, Ling, Schotel, Roka, Moreira-Teixeira, Liliana, van den Doel, Mirella, Leijten, Jeroen C H, Riesle, Jens, Karperien, Marcel, van Blitterswijk, Clemens A, Moroni, Lorenzo

“…Animal experiments help to progress and ensure safety of an increasing number of novel therapies, drug development and chemicals. Unfortunately, these also…”
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In vivo screening of extracellular matrix components produced under multiple experimental conditions implanted in one animalElectronic supplementary information (ESI) available. See DOI: 10.1039/c3ib40023a by Higuera, Gustavo A, Hendriks, Jeanine A. A, van Dalum, Joost, Wu, Ling, Schotel, Roka, Moreira-Teixeira, Liliana, van den Doel, Mirella, Leijten, Jeroen C. H, Riesle, Jens, Karperien, Marcel, van Blitterswijk, Clemens A, Moroni, Lorenzo

“…Animal experiments help to progress and ensure safety of an increasing number of novel therapies, drug development and chemicals. Unfortunately, these also…”
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