Search Results - "Leijten, Emmerik F.A."

Perception of self: distinguishing autoimmunity from autoinflammation by van Kempen, Tessa S., Wenink, Mark H., Leijten, Emmerik F. A., Radstake, Timothy R. D. J., Boes, Marianne

“…Key Points Autoimmunity and autoinflammatory disorders are distinct in terms of the predominance of underlying innate or adaptive immune mechanisms,…”
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ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts by Angiolilli, Chiara, Leijten, Emmerik F.A., Bekker, Cornelis P.J., Eeftink, Ella, Giovannone, Barbara, Nordkamp, Michel Olde, van der Wal, Marlot, Thijs, Judith L., Vastert, Sebastiaan J., van Wijk, Femke, Radstake, Timothy R.D.J., van Loosdregt, Jorg

“…Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production…”
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A precision medicine trial in psoriatic arthritis-first jump in the deep end by Leijten, Emmerik F A

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MYOSITIS, 1st edition, edited by H. Chinoy and R.G. Cooper by Leijten, Emmerik F A

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First-line csDMARD monotherapy drug retention in psoriatic arthritis: methotrexate outperforms sulfasalazine by Jacobs, Marleen E, Pouw, Juliëtte N, Welsing, Paco, Radstake, Timothy R D J, Leijten, Emmerik F A

“…Abstract Objectives Conventional synthetic DMARDs (csDMARDs) are the first-line treatment for PsA, but there is conflicting data regarding their efficacy and…”
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Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjögren’s syndrome by Blokland, Sofie L M, van den Hoogen, Lucas L, Leijten, Emmerik F A, Hartgring, Sarita A Y, Fritsch, Ruth, Kruize, Aike A, van Roon, Joel A G, Radstake, Timothy R D J

“…Abstract Objective The role of innate lymphoid cells (ILCs) in the pathophysiology of rheumatic diseases is emerging. Evidence from animal studies implicate…”
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CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis by Affandi, Alsya J., Silva‐Cardoso, Sandra C., Garcia, Samuel, Leijten, Emmerik F. A., Kempen, Tessa S., Marut, Wioleta, Roon, Joel A. G., Radstake, Timothy R. D. J.

“…CXCL4 regulates multiple facets of the immune response and is highly upregulated in various Th17‐associated rheumatic diseases. However, whether CXCL4 plays a…”
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Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis by Kempen, Tessa S., Leijten, Emmerik F.A., Lindenbergh, Marthe F.S., Nordkamp, Michel Olde, Driessen, Christoph, Lebbink, Robert‐Jan, Baerlecken, Niklas, Witte, Torsten, Radstake, Timothy R.D.J., Boes, Marianne

“…Ankylosing spondylitis (AS) is associated with autoantibody production to class II MHC‐associated invariant chain peptide, CD74/CLIP. In this study, we…”
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A pan‐inflammatory microRNA‐cluster is associated with orbital non‐Hodgkin lymphoma and idiopathic orbital inflammation by Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P. J., Hiddingh, Sanne, Veen, Rob L. P., Eenhorst, Christine A. E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F. A., Haitjema, Saskia, Groot, Mark C. H., Radstake, Timothy R. D. J., Boer, Joke H., Kuiper, Jonas J. W.

“…Non‐Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology that can be…”
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Review: Innate Lymphoid Cells: Sparking Inflammatory Rheumatic Disease? by Wenink, Mark H., Leijten, Emmerik F. A., Cupedo, Tom, Radstake, Timothy R. D. J.

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Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells by Pouw, Juliëtte N, Olde Nordkamp, Michel A M, O'Toole, Tom G, Radstake, Timothy R D J, Leijten, Emmerik F A, Boes, Marianne

“…IntroductionPlasmacytoid dendritic cells (pDCs) are the main producers of type I interferon (IFN) in SLE. pDCs express high secretory carrier membrane protein…”
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DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease by Jacobs, Marleen E, Pouw, Juliëtte N, Olde Nordkamp, Michel A, Radstake, Timothy R D J, Leijten, Emmerik F A, Boes, Marianne

“…Summary Objectives Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can…”
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Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT by Kleinrensink, Nienke J, Foppen, Wouter, Ten Katen, Iris, van der Veen, Pieternella H, de Klerk, Bo, Diepstraten, Suzanne C E, Radstake, Timothy R D J, Lafeber, Floris P J G, de Jong, Pim A, Leijten, Emmerik F A

“…ObjectiveTo compare the Heel Enthesitis MRI Scoring model (HEMRIS) with clinical and PET/CT outcomes in patients with cutaneous psoriasis (Pso), psoriatic…”
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