Search Results - "Leijten, Emmerik F. A."

Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies by Pouw, Juliëtte N., Olde Nordkamp, Michel A. M., van Kempen, Tessa, Concepcion, Arno N., van Laar, Jacob M., van Wijk, Femke, Spierings, Julia, Leijten, Emmerik F. A., Boes, Marianne

“…In psoriatic arthritis (PsA), predisposing class I HLA alleles, the presence of synovial clonally proliferated CD8 + T cells and autoantibodies all point…”
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Suppression of IL‐12/IL‐23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon‐γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon‐driven diseases by Vincken, Nanette L. A., Welsing, Paco M. J., Silva‐Cardoso, Sandra C., Bekker, Cornelis P. J., Lopes, Ana P., Olde Nordkamp, Michel, Leijten, Emmerik F. A., Radstake, Timothy R. D. J., Angiolilli, Chiara

“…Interleukin (IL)‐12 and IL‐23 are pro‐inflammatory cytokines produced by dendritic cells (DCs) and associated with Psoriasis (Pso) and Psoriatic Arthritis…”
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Author Correction: Regulatory T cells in psoriatic arthritis: an IL-17A-producing, Foxp3intCD161 + RORγt + ICOS + phenotype, that associates with the presence of ADAMTSL5 autoantibodies by Pouw, Juliëtte N., Olde Nordkamp, Michel A. M., van Kempen, Tessa, Concepcion, Arno N., van Laar, Jacob M., van Wijk, Femke, Spierings, Julia, Leijten, Emmerik F. A., Boes, Marianne

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Review: Innate Lymphoid Cells: Sparking Inflammatory Rheumatic Disease? by Wenink, Mark H., Leijten, Emmerik F. A., Cupedo, Tom, Radstake, Timothy R. D. J.

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Perception of self: distinguishing autoimmunity from autoinflammation by van Kempen, Tessa S., Wenink, Mark H., Leijten, Emmerik F. A., Radstake, Timothy R. D. J., Boes, Marianne

“…Key Points Autoimmunity and autoinflammatory disorders are distinct in terms of the predominance of underlying innate or adaptive immune mechanisms,…”
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TOFA-PREDICT study protocol: a stratification trial to determine key immunological factors predicting tofacitinib efficacy and drug-free remission in psoriatic arthritis (PsA) by Kleinrensink, Nienke J, Perton, Frank T, Pouw, Juliëtte N, Vincken, Nanette L A, Hartgring, Sarita A Y, Jansen, Mylène P, Arbabi, Saeed, Foppen, Wouter, de Jong, Pim A, Tekstra, Janneke, Leijten, Emmerik F A, Spierings, Julia, Lafeber, Floris P J G, Welsing, Paco M J, Heijstek, Marloes W

“…IntroductionPsoriatic arthritis (PsA) is a chronic, inflammatory, musculoskeletal disease that affects up to 30% of patients with psoriasis. Current challenges…”
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Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti‐CD74 autoantibodies in human ankylosing spondylitis by Kempen, Tessa S., Leijten, Emmerik F.A., Lindenbergh, Marthe F.S., Nordkamp, Michel Olde, Driessen, Christoph, Lebbink, Robert‐Jan, Baerlecken, Niklas, Witte, Torsten, Radstake, Timothy R.D.J., Boes, Marianne

“…Ankylosing spondylitis (AS) is associated with autoantibody production to class II MHC‐associated invariant chain peptide, CD74/CLIP. In this study, we…”
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Activation-induced colocalisation of SCAMP5 with IFNα in human plasmacytoid dendritic cells by Pouw, Juliëtte N, Olde Nordkamp, Michel A M, O'Toole, Tom G, Radstake, Timothy R D J, Leijten, Emmerik F A, Boes, Marianne

“…IntroductionPlasmacytoid dendritic cells (pDCs) are the main producers of type I interferon (IFN) in SLE. pDCs express high secretory carrier membrane protein…”
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Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT by Kleinrensink, Nienke J, Foppen, Wouter, Ten Katen, Iris, van der Veen, Pieternella H, de Klerk, Bo, Diepstraten, Suzanne C E, Radstake, Timothy R D J, Lafeber, Floris P J G, de Jong, Pim A, Leijten, Emmerik F A

“…ObjectiveTo compare the Heel Enthesitis MRI Scoring model (HEMRIS) with clinical and PET/CT outcomes in patients with cutaneous psoriasis (Pso), psoriatic…”
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Brief Report: Enrichment of Activated Group 3 Innate Lymphoid Cells in Psoriatic Arthritis Synovial Fluid by Leijten, Emmerik F. A., van Kempen, Tessa S., Boes, Marianne, Michels‐van Amelsfort, Jocea M. R., Hijnen, Dirkjan, Hartgring, Sarita A. Y., van Roon, Joel A. G., Wenink, Mark H., Radstake, Timothy R. D. J.

“…Objective Innate lymphoid cells (ILCs) are a recently discovered group of cells that are essential to epithelial homeostasis and are implicated in psoriasis…”
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ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts by Angiolilli, Chiara, Leijten, Emmerik F.A., Bekker, Cornelis P.J., Eeftink, Ella, Giovannone, Barbara, Nordkamp, Michel Olde, van der Wal, Marlot, Thijs, Judith L., Vastert, Sebastiaan J., van Wijk, Femke, Radstake, Timothy R.D.J., van Loosdregt, Jorg

“…Dermal fibroblasts are strategically positioned underneath the basal epidermis layer to support keratinocyte proliferation and extracellular matrix production…”
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A precision medicine trial in psoriatic arthritis-first jump in the deep end by Leijten, Emmerik F A

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MYOSITIS, 1st edition, edited by H. Chinoy and R.G. Cooper by Leijten, Emmerik F A

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First-line csDMARD monotherapy drug retention in psoriatic arthritis: methotrexate outperforms sulfasalazine by Jacobs, Marleen E, Pouw, Juliëtte N, Welsing, Paco, Radstake, Timothy R D J, Leijten, Emmerik F A

“…Abstract Objectives Conventional synthetic DMARDs (csDMARDs) are the first-line treatment for PsA, but there is conflicting data regarding their efficacy and…”
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Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjögren’s syndrome by Blokland, Sofie L M, van den Hoogen, Lucas L, Leijten, Emmerik F A, Hartgring, Sarita A Y, Fritsch, Ruth, Kruize, Aike A, van Roon, Joel A G, Radstake, Timothy R D J

“…Abstract Objective The role of innate lymphoid cells (ILCs) in the pathophysiology of rheumatic diseases is emerging. Evidence from animal studies implicate…”
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CXCL4 is a novel inducer of human Th17 cells and correlates with IL‐17 and IL‐22 in psoriatic arthritis by Affandi, Alsya J., Silva‐Cardoso, Sandra C., Garcia, Samuel, Leijten, Emmerik F. A., Kempen, Tessa S., Marut, Wioleta, Roon, Joel A. G., Radstake, Timothy R. D. J.

“…CXCL4 regulates multiple facets of the immune response and is highly upregulated in various Th17‐associated rheumatic diseases. However, whether CXCL4 plays a…”
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A pan‐inflammatory microRNA‐cluster is associated with orbital non‐Hodgkin lymphoma and idiopathic orbital inflammation by Laban, Kamil G., Kalmann, Rachel, Bekker, Cornelis P. J., Hiddingh, Sanne, Veen, Rob L. P., Eenhorst, Christine A. E., Genders, Stijn W., Mourits, Maarten P., Verhagen, Fleurieke H., Leijten, Emmerik F. A., Haitjema, Saskia, Groot, Mark C. H., Radstake, Timothy R. D. J., Boer, Joke H., Kuiper, Jonas J. W.

“…Non‐Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology that can be…”
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Longitudinal Follow-Up Using the Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) Shows Minimal Changes in Heel Enthesitis Assessed in Spondyloarthritis and Psoriasis Patients by Kleinrensink, Nienke J, Foppen, Wouter, Katen, Iris Ten, Leijten, Emmerik F A, de Jong, Pim A, Spierings, Julia

“…Enthesitis is a common clinical feature of spondyloarthritis (SpA). For reliable assessment of enthesitis the Heel Enthesitis Magnetic Resonance Imaging…”
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DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease by Jacobs, Marleen E, Pouw, Juliëtte N, Olde Nordkamp, Michel A, Radstake, Timothy R D J, Leijten, Emmerik F A, Boes, Marianne

“…Summary Objectives Signals at the contact site of antigen-presenting cells (APCs) and T cells help orchestrate the adaptive immune response. CD155 on APCs can…”
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Multimodal Imaging of Structural Damage and Inflammation in Psoriatic Arthritis: A comparison of DMARD-Naive and DMARD-Failure Patients by Renkli, Nağme Ö, Kleinrensink, Nienke J, Spierings, Julia, Mastbergen, Simon, Vonkeman, Harald E, Mooij, Shasti C, Schipper, Lydia, Herman, Amin, Ten Katen, Iris, Nap, Frank J, Hol, Marjolein E, de Jong, Pim A, Jansen, Mylène P, Foppen, Wouter

“…To compare inflammatory and structural differences in active Psoriatic Arthritis (PsA) between disease-modifying antirheumatic drug (DMARD)-naive and…”
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