Search Results - "Leighton, Matthew"

Performance scaling and trade-offs for collective motor-driven transport by Leighton, Matthew P, Sivak, David A

“…Abstract Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often…”
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Dynamic and Thermodynamic Bounds for Collective Motor-Driven Transport by Leighton, Matthew P., Sivak, David A.

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Inferring Subsystem Efficiencies in Bipartite Molecular Machines by Leighton, Matthew P, Sivak, David A

“…Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and…”
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Non-equilibrium growth and twist of cross-linked collagen fibrils by Leighton, Matthew P, Kreplak, Laurent, Rutenberg, Andrew D

“…The lysyl oxidase (LOX) enzyme that catalyses cross-link formation during the assembly of collagen fibrils in vivo is too large to diffuse within assembled…”
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D-band strain underestimates fibril strain for twisted collagen fibrils at low strains by Leighton, Matthew P., Rutenberg, Andrew D., Kreplak, Laurent

“…Collagen fibrils are the main structural component of load-bearing tissues such as tendons, ligaments, skin, the cornea of the eye, and the heart. The D-band…”
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Information Arbitrage in Bipartite Heat Engines by Leighton, Matthew P., Ehrich, Jannik, Sivak, David A.

“…Heat engines and information engines have each historically served as motivating examples for the development of thermodynamics. While these two types of…”
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Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial by Leighton, Matthew P, Lam, Ching, Mehta, Samir, Spiller, Robin C

“…Irritable bowel syndrome (IBS) is reported by one in ten of the population accounting for up to 40% of new referrals to gastroenterology outpatients. Patients…”
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A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia by Suleman, Farhana, Gualeni, Benedetta, Gregson, Hannah J., Leighton, Matthew P., Piróg, Katarzyna A., Edwards, Sarah, Holden, Paul, Boot-Handford, Raymond P., Briggs, Michael D.

“…Pseudoachondroplasia (PSACH) results from mutations in cartilage oligomeric matrix protein (COMP) and the p.D469del mutation within the type III repeats of…”
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Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation by Leighton, Matthew P., Nundlall, Seema, Starborg, Tobias, Meadows, Roger S., Suleman, Farhana, Knowles, Lynette, Wagener, Raimund, Thornton, David J., Kadler, Karl E., Boot-Handford, Raymond P., Briggs, Michael D.

“…Disruption to endochondral ossification leads to delayed and irregular bone formation and can result in a heterogeneous group of genetic disorders known as the…”
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‘Mosaic Covenant’ as a Possible Referent for νόμοϛ in Paul by Matthew B. Leighton

“…Any serious enquiry into Paul’s view of the law must include lexical considerations regarding the meaning of νόμος (‘law’) itself. A general consensus has…”
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Multiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3 by Cotterill, Sally L., Jackson, Gail C., Leighton, Matthew P., Wagener, Raimund, Mäkitie, Outi, Cole, William G., Briggs, Michael D.

“…Multiple epiphyseal dysplasia (MED) is a relatively common skeletal dysplasia that can present in childhood with a variable phenotype of short stature and pain…”
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Performance trade-offs for collective motor-driven transport by Leighton, Matthew P., Sivak, David A.

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Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): a multicentre, parallel-group, randomised placebo-controlled trial by Lam, Ching, Tan, Wei, Leighton, Matthew, Hastings, Margaret, Lingaya, Melanie, Falcone, Yirga, Zhou, Xiaoying, Xu, Luting, Whorwell, Peter, Walls, Andrew F, Zaitoun, Abed, Montgomery, Alan, Spiller, Robin C

“…Background Diarrhoea-predominant irritable bowel syndrome (IBS-D) is a common outcome after inflammation due to bacterial gastroenteritis. Several studies have…”
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Multi-agency partnerships in cybercrime reduction: Mapping the UK information assurance network cooperation space by Levi, Michael, Williams, Matthew Leighton

“…Purpose – This paper aims to map out multi-agency partnerships in the UK information assurance (UKIA) network in the UK. Design/methodology/approach – The…”
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Environmental Performance of Green Building Code and Certification Systems by Suh, Sangwon, Tomar, Shivira, Leighton, Matthew, Kneifel, Joshua

“…We examined the potential life-cycle environmental impact reduction of three green building code and certification (GBCC) systems: LEED, ASHRAE 189.1, and…”
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Interoperability between ecoinvent ver. 3 and US LCI database: a case study by Suh, Sangwon, Leighton, Matthew, Tomar, Shivira, Chen, Christine

“…Purpose Building a global Life Cycle Inventory (LCI) database from scratch with a harmonized method and wide process coverage would require significant…”
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Large multi‐centre pilot randomized controlled trial testing a low‐cost, tailored, self‐help smoking cessation text message intervention for pregnant smokers (MiQuit) by Naughton, Felix, Cooper, Sue, Foster, Katharine, Emery, Joanne, Leonardi‐Bee, Jo, Sutton, Stephen, Jones, Matthew, Ussher, Michael, Whitemore, Rachel, Leighton, Matthew, Montgomery, Alan, Parrott, Steve, Coleman, Tim

“…Aims To estimate the effectiveness of pregnancy smoking cessation support delivered by short message service (SMS) text message and key parameters needed to…”
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A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D) by Lam, Ching, Tan, Wei, Leighton, Matthew, Hastings, Margaret, Lingaya, Melanie, Falcone, Yirga, Zhou, Xiaoying, Xu, Luting, Whorwell, Peter, Walls, Andrew F, Zaitoun, Abed, Montgomery, Alan, Spiller, Robin

“…Immune activation has been reported in the mucosa of IBS patients with diarrhoea (IBS-D), and some small studies have suggested that mesalazine may reduce…”
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Environmental Performance of Green Building Code and Certification Systems by Suh, Sangwon, Tomar, Shivira, Leighton, Matthew, Kneifel, Joshua

“…We examined the potential life-cycle environmental impact reduction of three green building code and certification (GBCC) systems: LEED, ASHRAE 189.1, and…”
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Multiple epiphyseal dysplasia mutations inMATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3 by Cotterill, Sally L., Jackson, Gail C., Leighton, Matthew P., Wagener, Raimund, Mäkitie, Outi, Cole, William G., Briggs, Michael D.

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