Search Results - "Leight, Susan N"

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer's disease by Gibbons, Garrett S, Kim, Soo-Jung, Wu, Qihui, Riddle, Dawn M, Leight, Susan N, Changolkar, Lakshmi, Xu, Hong, Meymand, Emily S, O'Reilly, Mia, Zhang, Bin, Brunden, Kurt R, Trojanowski, John Q, Lee, Virginia M Y

“…The spread of tau pathology in Alzheimer's disease (AD) is mediated by cell-to-cell transmission of pathological tau seeds released from neurons that, upon…”
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Thromboxane Receptor Activation Mediates Isoprostane-Induced Increases in Amyloid Pathology in Tg2576 Mice by Shineman, Diana W, Zhang, Bin, Leight, Susan N, Pratico, Domenico, Lee, Virginia M.-Y

“…Alzheimer's disease (AD) amyloid plaques are composed of amyloid-beta (Abeta) peptides produced from proteolytic cleavage of amyloid precursor protein (APP)…”
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Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies by Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Changolkar, Lakshmi, Riddle, Dawn M, Leight, Susan N, Irwin, David J, Trojanowski, John Q, Lee, Virginia M Y

“…Abstract Aggregation of tau into fibrillar structures within the CNS is a pathological hallmark of a clinically heterogeneous set of neurodegenerative diseases…”
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GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils by Gibbons, Garrett S, Banks, Rachel A, Kim, Bumjin, Xu, Hong, Changolkar, Lakshmi, Leight, Susan N, Riddle, Dawn M, Li, Chi, Gathagan, Ronald J, Brown, Hannah J, Zhang, Bin, Trojanowski, John Q, Lee, Virginia M-Y

“…Neurodegenerative proteinopathies characterized by intracellular aggregates of tau proteins, termed tauopathies, include Alzheimer's disease (AD),…”
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Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils by Zhang, Bin, Kehm, Victoria, Gathagan, Ron, Leight, Susan N, Trojanowski, John Q, Lee, Virginia M-Y, Luk, Kelvin C

“…The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common feature found in…”
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Accelerated Aβ Deposition in APPswe/PS1ΔE9 Mice with Hemizygous Deletions of TTR (Transthyretin) by Choi, Se Hoon, Leight, Susan N., Lee, Virginia M.-Y., Li, Tong, Wong, Philip C., Johnson, Jeffrey A., Saraiva, Maria J., Sisodia, Sangram S.

“…A cardinal pathological lesion of Alzheimer's disease (AD) is the deposition of amyloid β (Aβ) in the brain. We previously reported that exposing transgenic…”
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Accelerated A{beta} Deposition in APPswe/PS1 Delta E9 Mice with Hemizygous Deletions of TTR (Transthyretin) by Choi, Se Hoon, Leight, Susan N, Lee, Virginia M-Y, Li, Tong, Wong, Philip C, Johnson, Jeffrey A, Saraiva, Maria J, Sisodia, Sangram S

“…A cardinal pathological lesion of Alzheimer's disease (AD) is the deposition of amyloid {szligbeta} (A{szligbeta}) in the brain. We previously reported that…”
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Accelerated A{beta} Deposition in APPswe/PS1{Delta}E9 Mice with Hemizygous Deletions of TTR (Transthyretin) by Choi, Se Hoon, Leight, Susan N, Lee, Virginia M.-Y, Li, Tong, Wong, Philip C, Johnson, Jeffrey A, Saraiva, Maria J, Sisodia, Sangram S

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Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin) by Choi, Se Hoon, Leight, Susan N, Lee, Virginia M-Y, Li, Tong, Wong, Philip C, Johnson, Jeffrey A, Saraiva, Maria J, Sisodia, Sangram S

“…A cardinal pathological lesion of Alzheimer's disease (AD) is the deposition of amyloid beta (Abeta) in the brain. We previously reported that exposing…”
Get full text