Search Results - "Leight, Jennifer L"

Matrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition by Leight, Jennifer L, Wozniak, Michele A, Chen, Sophia, Lynch, Michelle L, Chen, Christopher S

“…The transforming growth factor-β (TGF-β) signaling pathway is often misregulated during cancer progression. In early stages of tumorigenesis, TGF-β acts as a…”
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Extracellular Matrix Remodeling and Stiffening Modulate Tumor Phenotype and Treatment Response by Leight, Jennifer L, Drain, Allison P, Weaver, Valerie M

“…Solid tumors are characterized by a remodeled and stiffened extracellular matrix. The extracellular matrix is not a passive by-product of the tumor, but…”
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Development of a Cellularly Degradable PEG Hydrogel to Promote Articular Cartilage Extracellular Matrix Deposition by Sridhar, Balaji V., Brock, John L., Silver, Jason S., Leight, Jennifer L., Randolph, Mark A., Anseth, Kristi S.

“…Healing articular cartilage remains a significant clinical challenge because of its limited self‐healing capacity. While delivery of autologous chondrocytes to…”
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Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland by Jones, Caitlin E., Hammer, Anisha M., Cho, YouJin, Sizemore, Gina M., Cukierman, Edna, Yee, Lisa D., Ghadiali, Samir N., Ostrowski, Michael C., Leight, Jennifer L.

“…The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor…”
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A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity by Dedhia, Priya H., Sivakumar, Hemamylammal, Rodriguez, Marco A., Nairon, Kylie G., Zent, Joshua M., Zheng, Xuguang, Jones, Katie, Popova, Liudmila V., Leight, Jennifer L., Skardal, Aleksander

“…Adrenocortical carcinoma (ACC) has a poor prognosis, and no new drugs have been identified in decades. The absence of drug development can partly be attributed…”
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MDM2 Derived from Dedifferentiated Liposarcoma Extracellular Vesicles Induces MMP2 Production from Preadipocytes by Casadei, Lucia, Calore, Federica, Braggio, Danielle A, Zewdu, Abeba, Deshmukh, Ameya A, Fadda, Paolo, Lopez, Gonzalo, Wabitsch, Martin, Song, Chi, Leight, Jennifer L, Grignol, Valerie P, Lev, Dina, Croce, Carlo M, Pollock, Raphael E

“…Dedifferentiated liposarcoma (DDLPS) is frequently diagnosed late, and patients typically respond poorly to treatments. DDLPS is molecularly characterized by…”
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Multifunctional bioscaffolds for 3D culture of melanoma cells reveal increased MMP activity and migration with BRAF kinase inhibition by Leight, Jennifer L., Tokuda, Emi Y., Jones, Caitlin E., Lin, Austin J., Anseth, Kristi S.

“…Matrix metalloproteinases (MMPs) are important for many different types of cancer-related processes, including metastasis. Understanding the functional impact…”
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Pten regulates collagen fibrillogenesis by fibroblasts through SPARC by Jones, Caitlin E, Sharick, Joe T, Colbert, Sheila E, Shukla, Vasudha C, Zent, Joshua M, Ostrowski, Michael C, Ghadiali, Samir N, Sizemore, Steven T, Leight, Jennifer L

“…Collagen deposition contributes to both high mammographic density and breast cancer progression. Low stromal PTEN expression has been observed in as many as…”
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In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness by Wormsbaecher, Clarissa, Hindman, Andrea R, Avendano, Alex, Cortes-Medina, Marcos, Jones, Caitlin E, Bushman, Andrew, Onua, Lotanna, Kovalchin, Claire E, Murphy, Alina R, Helber, Hannah L, Shapiro, Ali, Voytovitch, Kyle, Kuang, Xingyan, Aguilar-Valenzuela, Renan, Leight, Jennifer L, Song, Jonathan W, Burd, Craig J

“…In utero endocrine disruption is linked to increased risk of breast cancer later in life. Despite numerous studies establishing this linkage, the long-term…”
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Detection of proteolytic activity by covalent tethering of fluorogenic substrates in zymogram gels by Deshmukh, Ameya A, Weist, Jessica L, Leight, Jennifer L

“…Current zymographic techniques detect only a subset of known proteases due to the limited number of native proteins that have been optimized for incorporation…”
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Tumor cell-conditioned media drives collagen remodeling via fibroblast and pericyte activation in an in vitro premetastatic niche model by Nairon, Kylie G., DePalma, Thomas J., Zent, Joshua M., Leight, Jennifer L., Skardal, Aleksander

“…Primary tumors secrete large quantities of cytokines and exosomes into the bloodstream, which are uptaken at downstream sites and induce a pro-fibrotic,…”
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Three dimensional models of dedifferentiated liposarcoma cell lines: scaffold-based and scaffold-free approaches by Tahara, Sayumi, de Faria, Fernanda Costas C., Sarchet, Patricia, Calore, Federica, Sharick, Joe, Leight, Jennifer L., Casadei, Lucia, Pollock, Raphael E.

“…Sarcomas are rare malignancies, the number of reports is limited, and this rarity makes further research difficult even though liposarcoma is one of major…”
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Click chemistry functionalization of self‐assembling peptide hydrogels by Sharick, Joe T., Atieh, Angelina J., Gooch, Keith J., Leight, Jennifer L.

“…Self‐assembling peptide (SAP) hydrogels provide a fibrous microenvironment to cells while also giving users control of biochemical and mechanical cues…”
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Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer by Drain, Allison P, Zahir, Nastaran, Northey, Jason J, Zhang, Hui, Huang, Po-Jui, Maller, Ori, Lakins, Johnathon N, Yu, Xinmiao, Leight, Jennifer L, Alston-Mills, Brenda P, Hwang, E Shelley, Chen, Yunn-Yi, Park, Catherine C, Weaver, Valerie M

“…Triple-negative breast cancers (TNBCs) are associated with poor survival mediated by treatment resistance. TNBCs are fibrotic, yet little is known regarding…”
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Direct measurement of matrix metalloproteinase activity in 3D cellular microenvironments using a fluorogenic peptide substrate by Leight, Jennifer L, Alge, Daniel L, Maier, Andrew J, Anseth, Kristi S

“…Abstract Incorporation of degradable moieties into synthetic hydrogels has greatly increased the utility of these three-dimensional matrices for in vitro cell…”
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Modulation of matrix elasticity with PEG hydrogels to study melanoma drug responsiveness by Tokuda, Emi Y, Leight, Jennifer L, Anseth, Kristi S

“…Abstract Metastatic melanoma is highly resistant to drug treatment, and the underlying mechanisms of this resistance remain unclear. Increased tissue stiffness…”
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Negative normal stress in semiflexible biopolymer gels by Janmey, Paul A, MacKintosh, Fred C, McCormick, Margaret E, Rammensee, Sebastian, Leight, Jennifer L, Georges, Penelope C

“…When subject to stress or external loads, most materials resist deformation. Any stable material, for instance, resists compression-even liquids. Solids also…”
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Measuring Global Cellular Matrix Metalloproteinase and Metabolic Activity in 3D Hydrogels by Fakhouri, Abdulaziz S, Leight, Jennifer L

“…Three-dimensional (3D) cell culture systems often more closely recapitulate in vivo cellular responses and functions than traditional two-dimensional (2D)…”
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Myoferlin regulates epithelial cancer cell plasticity and migration through autocrine TGF-β1 signaling by Barnhouse, Victoria R, Weist, Jessica L, Shukla, Vasudha C, Ghadiali, Samir N, Kniss, Douglas A, Leight, Jennifer L

“…Epithelial cancer cells can undergo an epithelial-mesenchymal transition (EMT), a complex genetic program that enables cells to break free from the primary…”
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High-Throughput Three-Dimensional Hydrogel Cell Encapsulation Assay for Measuring Matrix Metalloproteinase Activity by Fakhouri, Abdulaziz S, Weist, Jessica L, Tomusko, Anthony R, Leight, Jennifer L

“…Three-dimensional (3D) cell culture systems more closely mimic the in vivo cellular microenvironment than traditional two-dimensional cell culture methods,…”
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