Search Results - "Leigh-Ana Rossitto"

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia by Campeau, Anaamika, Mills, Robert H., Stevens, Toer, Rossitto, Leigh-Ana, Meehan, Michael, Dorrestein, Pieter, Daly, Rebecca, Nguyen, Tanya T., Gonzalez, David J., Jeste, Dilip V., Hook, Vivian

“…Schizophrenia is a devastating psychiatric illness that detrimentally affects a significant portion of the worldwide population. Aging of schizophrenia…”
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Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice by Yuskaitis, Christopher J, Rossitto, Leigh-Ana, Gurnani, Sarika, Bainbridge, Elizabeth, Poduri, Annapurna, Sahin, Mustafa

“…Abstract DEPDC5 is now recognized as one of the genes most often implicated in familial/inherited focal epilepsy and brain malformations. Individuals with…”
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Amplification of Inflammation by Lubricin Deficiency Implicated in Incident, Erosive Gout Independent of Hyperuricemia by Elsaid, Khaled, Merriman, Tony R., Rossitto, Leigh‐Ana, Liu‐Bryan, Ru, Karsh, Jacob, Phipps‐Green, Amanda, Jay, Gregory D., Elsayed, Sandy, Qadri, Marwa, Miner, Marin, Cadzow, Murray, Dambruoso, Talia J., Schmidt, Tannin A., Dalbeth, Nicola, Chhana, Ashika, Höglund, Jennifer, Ghassemian, Majid, Campeau, Anaamika, Maltez, Nancy, Karlsson, Niclas G., Gonzalez, David J., Terkeltaub, Robert

“…Objective In gout, hyperuricemia promotes urate crystal deposition, which stimulates the NLRP3 inflammasome and interleukin‐1β (IL‐1β)–mediated arthritis…”
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Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition by Pilo, Caila A, Baffi, Timothy R, Kornev, Alexandr P, Kunkel, Maya T, Malfavon, Mario, Chen, Dong-Hui, Rossitto, Leigh-Ana, Chen, Daniel X, Huang, Liang-Chin, Longman, Cheryl, Kannan, Natarajan, Raskind, Wendy H, Gonzalez, David J, Taylor, Susan S, Gorrie, George, Newton, Alexandra C

“…Spinocerebellar ataxia type 14 (SCA14) is a neurodegenerative disease caused by germline variants in the diacylglycerol (DAG)/Ca -regulated protein kinase Cγ…”
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Factors influencing the acute pentylenetetrazole‐induced seizure paradigm and a literature review by Yuskaitis, Christopher J., Rossitto, Leigh‐Ana, Groff, Karenna J., Dhamne, Sameer C., Zhang, Bo, Lalani, Lahin K., Singh, Achint K., Rotenberg, Alexander, Sahin, Mustafa

“…Objective To confirm the critical factors affecting seizure susceptibility in acute pentylenetetrazole (PTZ) mouse epilepsy models and evaluate the prior…”
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The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients by Gonzalez, Carlos G., Mills, Robert H., Kordahi, Melissa C., Carrillo-Terrazas, Marvic, Secaira-Morocho, Henry, Widjaja, Christella E., Tsai, Matthew S., Mittal, Yash, Yee, Brian A., Vargas, Fernando, Weldon, Kelly, Gauglitz, Julia M., Delaroque, Clara, Sauceda, Consuelo, Rossitto, Leigh-Ana, Ackermann, Gail, Humphrey, Gregory, Swafford, Austin D., Siegel, Corey A., Buckey, Jay C., Raffals, Laura E., Sadler, Charlotte, Lindholm, Peter, Fisch, Kathleen M., Valaseck, Mark, Suriawinata, Arief, Yeo, Gene W., Ghosh, Pradipta, Chang, John T., Chu, Hiutung, Dorrestein, Pieter, Zhu, Qiyun, Chassaing, Benoit, Knight, Rob, Gonzalez, David J., Dulai, Parambir S.

“…Hyperbaric oxygen therapy (HBOT) is a promising treatment for moderate-to-severe ulcerative colitis. However, our current understanding of the host and…”
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Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes by Russell, Baylee J., Brown, Steven D., Siguenza, Nicole, Mai, Irene, Saran, Anand R., Lingaraju, Amulya, Maissy, Erica S., Dantas Machado, Ana C., Pinto, Antonio F.M., Sanchez, Concepcion, Rossitto, Leigh-Ana, Miyamoto, Yukiko, Richter, R. Alexander, Ho, Samuel B., Eckmann, Lars, Hasty, Jeff, Gonzalez, David J., Saghatelian, Alan, Knight, Rob, Zarrinpar, Amir

“…Live bacterial therapeutics (LBTs) could reverse diseases by engrafting in the gut and providing persistent beneficial functions in the host. However, attempts…”
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A novel gain-of-function phosphorylation site modulates PTPN22 inhibition of TCR signaling by Zhuang, Chuling, Yang, Shen, Gonzalez, Carlos G., Ainsworth, Richard I., Li, Sheng, Kobayashi, Masumi Takayama, Wierzbicki, Igor, Rossitto, Leigh-Ana M., Wen, Yutao, Peti, Wolfgang, Stanford, Stephanie M., Gonzalez, David J., Murali, Ramachandran, Santelli, Eugenio, Bottini, Nunzio

“…Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is encoded by a major autoimmunity gene and is a known inhibitor of T cell receptor (TCR) signaling…”
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Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer's Disease Brain by Podvin, Sonia, Jiang, Zhenze, Boyarko, Ben, Rossitto, Leigh-Ana, O'Donoghue, Anthony, Rissman, Robert A, Hook, Vivian

“…Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in cognitive deficits and brain neurodegeneration. Neuropeptides comprise…”
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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting by Yuskaitis, Christopher J., Modasia, Jinita B., Schrötter, Sandra, Rossitto, Leigh-Ana, Groff, Karenna J., Morici, Christopher, Mithal, Divakar S., Chakrabarty, Ram P., Chandel, Navdeep S., Manning, Brendan D., Sahin, Mustafa

“…Caloric restriction and acute fasting are known to reduce seizures but through unclear mechanisms. mTOR signaling has been suggested as a potential mechanism…”
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Dysregulation of Human Juvenile Huntington's Disease Brain Proteomes in Cortex and Putamen Involves Mitochondrial and Neuropeptide Systems by Podvin, Sonia, Mosier, Charles, Poon, William, Wei, Enlin, Rossotto, Leigh-Ana, Hook, Vivian

“…Huntington's disease (HD) is a genetic neurodegenerative disease caused by trinucleotide repeat CAG expansions in the human HTT gene. Early onset juvenile HD…”
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The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis PatientsSummary by Carlos G. Gonzalez, Robert H. Mills, Melissa C. Kordahi, Marvic Carrillo-Terrazas, Henry Secaira-Morocho, Christella E. Widjaja, Matthew S. Tsai, Yash Mittal, Brian A. Yee, Fernando Vargas, Kelly Weldon, Julia M. Gauglitz, Clara Delaroque, Consuelo Sauceda, Leigh-Ana Rossitto, Gail Ackermann, Gregory Humphrey, Austin D. Swafford, Corey A. Siegel, Jay C. Buckey, Jr, Laura E. Raffals, Charlotte Sadler, Peter Lindholm, Kathleen M. Fisch, Mark Valaseck, Arief Suriawinata, Gene W. Yeo, Pradipta Ghosh, John T. Chang, Hiutung Chu, Pieter Dorrestein, Qiyun Zhu, Benoit Chassaing, Rob Knight, David J. Gonzalez, Parambir S. Dulai

“…Background & Aims: Hyperbaric oxygen therapy (HBOT) is a promising treatment for moderate-to-severe ulcerative colitis. However, our current understanding of…”
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