Search Results - "Leigh James"

Localized Merkel cell carcinoma treatment considerations: a response to the forty-year experience at the Peter MacCallum cancer centre by Leigh, James, Gebauer, Kurt

“…Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine tumour of the skin with poor prognosis and rising global incidence. A recently published…”
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Validation of the days alive and out of hospital outcome measure after emergency laparotomy: a retrospective cohort study by Spurling, Leigh-James, Moonesinghe, S Ramani, Oliver, C Matthew

“…Days alive and out of hospital (DAOH) is a composite, patient-centred outcome measure describing a patient's postoperative recovery, encompassing…”
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Priming from within: TLR2 dependent but receptor independent activation of the mammary macrophage inflammasome by Streptococcus uberis by Hinds, Abbie, Ward, Philip, Archer, Nathan, Leigh, James

“…is a member of the pyogenic cluster of commonly associated with intramammary infection and mastitis in dairy cattle. It is a poorly controlled globally endemic…”
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Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions by Tomes, Abbie, Archer, Nathan, Leigh, James

“…Macrophages residing in milk are vital during intramammary infections. This study sought to develop a method enabling the investigation of macrophage responses…”
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Survival of Streptococcus uberis on bedding substrates by Sherwin, Virginia E., Egan, Sharon A., Green, Martin J., Leigh, James A.

“…•Streptococcus uberis survived on sand and straw bedding for at least 35 days.•Streptococcus uberis did not survive on sawdust for more than 7…”
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Streptococcus uberis strains isolated from the bovine mammary gland evade immune recognition by mammary epithelial cells, but not of macrophages by Günther, Juliane, Czabanska, Anna, Bauer, Isabel, Leigh, James A, Holst, Otto, Seyfert, Hans-Martin

“…Streptococcus uberis is frequently isolated from the mammary gland of dairy cattle. Infection with some strains can induce mild subclinical inflammation whilst…”
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Reinquiries in Advertising Research by Eisend, Martin, Franke, George R., Leigh, James H.

“…Journal of Advertising Reinquiries in Advertising Research…”
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Defining the ABC of gene essentiality in streptococci by Charbonneau, Amelia R L, Forman, Oliver P, Cain, Amy K, Newland, Graham, Robinson, Carl, Boursnell, Mike, Parkhill, Julian, Leigh, James A, Maskell, Duncan J, Waller, Andrew S

“…Utilising next generation sequencing to interrogate saturated bacterial mutant libraries provides unprecedented information for the assignment of genome-wide…”
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Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis by Ward, Philip N, Holden, Matthew T G, Leigh, James A, Lennard, Nicola, Bignell, Alexandra, Barron, Andy, Clark, Louise, Quail, Michael A, Woodward, John, Barrell, Bart G, Egan, Sharon A, Field, Terence R, Maskell, Duncan, Kehoe, Michael, Dowson, Christopher G, Chanter, Neil, Whatmore, Adrian M, Bentley, Stephen D, Parkhill, Julian

“…Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises…”
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Australia's Ongoing Legacy of Asbestos: Significant Challenges Remain Even after the Complete Banning of Asbestos Almost Fifteen Years Ago by Soeberg, Matthew, Vallance, Deborah A, Keena, Victoria, Takahashi, Ken, Leigh, James

“…The most effective way of reducing the global burden of asbestos-related diseases is through the implementation of asbestos bans and minimising occupational…”
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PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data by Blanchard, Adam M., Taylor, Adam, Warry, Andrew, Shephard, Freya, Curwen, Alice, Leigh, James A., Emes, Richard D., Egan, Sharon A.

“…Current methods for visualising and interrogating high-throughput transposon insertion mutagenesis sequencing (TIS) data requires a significant time investment…”
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Virulence related sequences; insights provided by comparative genomics of Streptococcus uberis of differing virulence by Hossain, Maqsud, Egan, Sharon A, Coffey, Tracey, Ward, Philip N, Wilson, Ray, Leigh, James A, Emes, Richard D

“…Streptococcus uberis, a Gram-positive, catalase-negative member of the family Streptococcaceae is an important environmental pathogen responsible for a…”
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Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle by Russell, Christopher D, Widdison, Stephanie, Leigh, James A, Coffey, Tracey J

“…Bovine mastitis remains the most common and costly disease of dairy cattle worldwide. A complementary control measure to herd hygiene and vaccine development…”
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Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch by Wu, Ming-Cheng, Lowe, Phillip T, Robinson, Christopher J, Vincent, Helen A, Dixon, Neil, Leigh, James, Micklefield, Jason

“…Re-engineered riboswitches that no longer respond to cellular metabolites, but that instead can be controlled by synthetic molecules, are potentially useful…”
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Estimating the global burden of low back pain attributable to combined occupational exposures by Punnett, Laura, Prüss-Ütün, Annette, Nelson, Deborah Imel, Fingerhut, Marilyn A., Leigh, James, Tak, SangWoo, Phillips, Sharonne

“…Background There is little information about the global burden of non‐traumatic low back pain (LBP) attributable to the effects of physical and psychosocial…”
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The global burden of disease due to occupational carcinogens by Driscoll, Timothy, Nelson, Deborah Imel, Steenland, Kyle, Leigh, James, Concha-Barrientos, Marisol, Fingerhut, Marilyn, Prüss-Üstün, Annette

“…Background The worldwide mortality and morbidity from lung cancer, leukemia, and malignant mesothelioma arising from occupational exposures to carcinogens are…”
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A Paradox in Bacterial Pathogenesis: Activation of the Local Macrophage Inflammasome Is Required for Virulence of Streptococcus uberis by Archer, Nathan, Egan, Sharon A, Coffey, Tracey J, Emes, Richard D, Addis, M Filippa, Ward, Philip N, Blanchard, Adam M, Leigh, James A

“…is a common cause of intramammary infection and mastitis in dairy cattle. Unlike other mammary pathogens, evades detection by mammary epithelial cells, and the…”
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Enzymatic Enantioselective Decarboxylative Protonation of Heteroaryl Malonates by Lewin, Ross, Goodall, Mark, Thompson, Mark L., Leigh, James, Breuer, Michael, Baldenius, Kai, Micklefield, Jason

“…The enzyme aryl/alkenyl malonate decarboxylase (AMDase) catalyses the enantioselective decarboxylative protonation (EDP) of a range of disubstituted malonic…”
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PIMMS (Pragmatic Insertional Mutation Mapping System) Laboratory Methodology a Readily Accessible Tool for Identification of Essential Genes in Streptococcus by Blanchard, Adam M, Egan, Sharon A, Emes, Richard D, Warry, Andrew, Leigh, James A

“…The Pragmatic Insertional Mutation Mapping (PIMMS) laboratory protocol was developed alongside various bioinformatics packages (Blanchard et al., 2015) to…”
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PCR-Based Direct Detection of Streptococcus uberis from Subclinical and Clinical Dairy Cattle Milk Samples by Egan, Sharon A., Coffey, Tracey J., Pickwell, Natalie D., Walker, Olivia, Santi, Morena, Sherwin, Virginia E., Leigh, James A.

“…Streptococcus uberis is one of the leading causes worldwide of mastitis in the dairy industry, with the most likely sources of infection attributed to…”
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