Search Results - "Leif E. Vinge"

G Protein-Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure by Raake, Philip W, Vinge, Leif E, Gao, Erhe, Boucher, Matthieu, Rengo, Giuseppe, Chen, Xiongwen, DeGeorge, Brent R, Matkovich, Scot, Houser, Steven R, Most, Patrick, Eckhart, Andrea D, Dorn, Gerald W, Koch, Walter J

“…Myocardial G protein-coupled receptor kinase (GRK)2 is a critical regulator of cardiac β-adrenergic receptor (βAR) signaling and cardiac function. Its…”
Get full text

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent Jr, Chuprun, J. Kurt, Harris, David M, Gao, Erhe, Eckhart, Andrea D, Pitcher, Julie A, Koch, Walter J

“…G protein-coupled receptor (GPCR) kinases (GRKs) are critical regulators of cellular signaling and function. In cardiomyocytes, GRK2 and GRK5 are two GRKs…”
Get full text

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury by Ahmed, M Shakil, Gravning, Jørgen, Martinov, Vladimir N, von Lueder, Thomas G, Edvardsen, Thor, Czibik, Gabor, Moe, Ingvild T, Vinge, Leif E, Øie, Erik, Valen, Guro, Attramadal, Håvard

“…CCN2/connective tissue growth factor (CTGF), a CCN family matricellular protein repressed in healthy hearts after birth, is induced in heart failure of various…”
Get more information

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts by Torp, May-Kristin, Yang, Kuan, Ranheim, Trine, Husø Lauritzen, Knut, Alfsnes, Katrine, Vinge, Leif E, Aukrust, Pål, Stensløkken, Kåre-Olav, Yndestad, Arne, Sandanger, Øystein

“…IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune…”
Get full text

Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure by Fosshaug, Linn E., MD, Dahl, Christen P., MD, PhD, Risnes, Ivar, MD, PhD, Bohov, Pavol, PhD, Berge, Rolf K., PhD, Nymo, Ståle, MD, Geiran, Odd, MD, PhD, Yndestad, Arne, PhD, Gullestad, Lars, MD, PhD, Aukrust, Pål, MD, PhD, Vinge, Leif E., MD, PhD, Øie, Erik, MD, PhD

“…Abstract Background Adipose tissue has endocrine properties, secreting a wide range of mediators into the circulation, including factors involved in…”
Get full text

Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress by DEGEORGE, Brent R, ERHE GAO, ECKHART, Andrea D, KOCH, Walter J, BOUCHER, Matthieu, VINGE, Leif E, MARTINI, Jeffrey S, RAAKE, Philip W, CHUPRUN, J. Kurt, HARRIS, David M, KIM, Gilbert W, SOLTYS, Stephen

“…A salient characteristic of dysfunctional myocardium progressing to heart failure is an upregulation of the adenylyl cyclase inhibitory guanine nucleotide (G)…”
Get full text

Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload by Waehre, Anne, Halvorsen, Bente, Yndestad, Arne, Husberg, Cathrine, Sjaastad, Ivar, Nygård, Ståle, Dahl, Christen P, Ahmed, M Shakil, Finsen, Alexandra V, Reims, Henrik, Louch, William E, Hilfiker-Kleiner, Denise, Vinge, Leif E, Roald, Borghild, Attramadal, Håvard, Lipp, Martin, Gullestad, Lars, Aukrust, Pål, Christensen, Geir

“…Inflammatory mechanisms have been suggested to play a role in the development of heart failure (HF), but a role for chemokines is largely unknown. Based on…”
Get full text

Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload by von Lueder, Thomas G, Gravning, Jørgen, How, Ole-Jakob, Vinge, Leif E, Ahmed, Mohammed Shakil, Krobert, Kurt A, Levy, Finn Olav, Larsen, Terje S, Smiseth, Otto A, Aasum, Ellen, Attramadal, Håvard

“…Transgenic mice with cardiac-specific expression of a peptide inhibitor of G protein-coupled receptor kinase (GRK)3 [transgenic COOH-terminal GRK3 (GRK3ct)…”
Get more information

Krill oil attenuates left ventricular dilatation after myocardial infarction in rats by Fosshaug, Linn E, Berge, Rolf K, Beitnes, Jan O, Berge, Kjetil, Vik, Hogne, Aukrust, Pål, Gullestad, Lars, Vinge, Leif E, Øie, Erik

“…In the western world, heart failure (HF) is one of the most important causes of cardiovascular mortality. Supplement with n-3 polyunsaturated fatty acids…”
Get full text

Wnt5a is elevated in heart failure and affects cardiac fibroblast function by Abraityte, Aurelija, Vinge, Leif E., Askevold, Erik T., Lekva, Tove, Michelsen, Annika E., Ranheim, Trine, Alfsnes, Katrine, Fiane, Arnt, Aakhus, Svend, Lunde, Ida G., Dahl, Christen P., Aukrust, Pål, Christensen, Geir, Gullestad, Lars, Yndestad, Arne, Ueland, Thor

“…Wnt signaling is dysregulated in heart failure (HF) and may promote cardiac hypertrophy, fibrosis, and inflammation. Blocking the Wnt ligand Wnt5a prevents HF…”
Get full text

Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle by Waehre, Anne, Vistnes, Maria, Sjaastad, Ivar, Nygård, Ståle, Husberg, Cathrine, Lunde, Ida Gjervold, Aukrust, Pål, Yndestad, Arne, Vinge, Leif E, Behmen, Dina, Neukamm, Christian, Brun, Henrik, Thaulow, Erik, Christensen, Geir

“…Chemokines have been suggested to play a role during development of left ventricular failure, but little is known about their role during right ventricular…”
Get full text

Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarction by Fosshaug, Linn E., Colas, Romain A., Anstensrud, Anne K., Gregersen, Ida, Nymo, Ståle, Sagen, Ellen L., Michelsen, Annika, Vinge, Leif E., Øie, Erik, Gullestad, Lars, Halvorsen, Bente, Hansen, Trond V., Aukrust, Pål, Dalli, Jesmond, Yndestad, Arne

“…Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to as…”
Get full text

Cardiac G-Protein―Coupled Receptor Kinase 2 Ablation Induces a Novel Ca2+ Handling Phenotype Resistant to Adverse Alterations and Remodeling After Myocardial Infarction by RAAKE, Philip W, XIAOYING ZHANG, HOUSER, Steven R, KATUS, Hugo A, XIONGWEN CHEN, KOCH, Walter J, VINGE, Leif E, BRINKS, Henriette, GAO, Erhe, JALEEL, Naser, YINGXIN LI, MINGXIN TANG, MOST, Patrick, DORN, Gerald W

“…G-protein-coupled receptor kinase 2 (GRK2) is a primary regulator of β-adrenergic signaling in the heart. G-protein-coupled receptor kinase 2 ablation impedes…”
Get full text

Tumor necrosis factor superfamily molecules in acute coronary syndromes by Aukrust, Pål, Sandberg, Wiggo J, Otterdal, Kari, Vinge, Leif E, Gullestad, Lars, Yndestad, Arne, Halvorsen, Bente, Ueland, Thor

“…Accumulating evidence suggests that inflammatory pathways play an essential role in all stages of atherogenesis. Inflammatory processes are not only involved…”
Get more information

Endothelial S100A1 Modulates Vascular Function via Nitric Oxide by Pleger, Sven T, Harris, David M, Shan, Changguang, Vinge, Leif E, Chuprun, J Kurt, Berzins, Brett, Pleger, Wiebke, Druckman, Charles, Völkers, Mirko, Heierhorst, Jörg, Øie, Erik, Remppis, Andrew, Katus, Hugo A, Scalia, Rosario, Eckhart, Andrea D, Koch, Walter J, Most, Patrick

“…S100A1, a Ca-binding protein of the EF-hand type, is known to modulate sarcoplasmic reticulum Ca handling in skeletal muscle and cardiomyocytes. Recently,…”
Get full text

Inhibition of angiotensin II Gq signaling augments β-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure by Harris, David M, Chen, Xiongwen, Pesant, Stéphanie, Cohn, Heather I, MacDonnell, Scott M, Boucher, Matthieu, Vinge, Leif E, Raake, Philip, Moraca, Susan R, Li, Dongjun, Most, Patrick, Houser, Steven R, Koch, Walter J, Eckhart, Andrea D

“…Abstract Chronic ventricular pressure overload states, such as hypertension, and elevated levels of neurohormones (norepinephrine, angiotensin II,…”
Get full text

Selectively Targeting Gi Signaling in Normal and Dysfunctional Myocardium by DeGeorge, Brent R, Gao, Erhe, Boucher, Matthieu, Vinge, Leif E, Martini, Jeffrey S, Raake, Philip W, Soltys, Stephen, Harris, David M, Chuprun, Kurt J, Eckhart, Andrea D, Koch, Walter J

Get full text

A Novel Nuclear Function for GRK5 and Its Potential Role in the Hypertrophic Response by Martini, Jeffrey S, Raake, Philip, Vinge, Leif E, DeGeorge, Brent R, Chuprun, John K, Harris, David M, Eckhart, Andrea E, Pitcher, Julie A, Koch, Walter J

Get full text

Early increase of specialized pro-resolving lipid mediators in patients with ST-elevation myocardial infarctionResearch in context by Linn E. Fosshaug, Romain A. Colas, Anne K. Anstensrud, Ida Gregersen, Ståle Nymo, Ellen L. Sagen, Annika Michelsen, Leif E. Vinge, Erik Øie, Lars Gullestad, Bente Halvorsen, Trond V. Hansen, Pål Aukrust, Jesmond Dalli, Arne Yndestad

“…Background: Termination of acute inflammation is an active process orchestrated by lipid mediators (LM) derived from polyunsaturated fatty acids, referred to…”
Get full text

Abstract 163: Inhibition of p38a Regulates SERCA2a Function by Kaikkonen, Leena, Magga, Johanna, Ronkainen, Veli-Pekka, Koivisto, Elina, Perjes, ábel, Chuprun, Kurt, Vinge, Leif E, Aro, Jani, Ulvila, Johanna, Alakoski, Tarja, Bibb, James, Szokodi, Istvan, Koch, Walter J, Ruskoaho, Heikki, Kerkelä, Risto

“…Abstract only Rationale: p38 MAPK is a negative regulator of cardiac contractile function, but the underlying molecular mechanism is not well understood…”
Get full text