Search Results - "Leier, Hans"

Cannabinoids Block Cellular Entry of SARS-CoV‑2 and the Emerging Variants by van Breemen, Richard B, Muchiri, Ruth N, Bates, Timothy A, Weinstein, Jules B, Leier, Hans C, Farley, Scotland, Tafesse, Fikadu G

“…As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2…”
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Lipids and pathogenic flaviviruses: An intimate union by Leier, Hans C, Messer, William B, Tafesse, Fikadu G

“…Flaviviridae: A growing family of human pathogens Among the major contributors to the positive-strand RNA virus global disease burden are the flaviviruses, a…”
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Age-Dependent Neutralization of SARS-CoV-2 and P.1 Variant by Vaccine Immune Serum Samples by Bates, Timothy A, Leier, Hans C, Lyski, Zoe L, Goodman, James R, Curlin, Marcel E, Messer, William B, Tafesse, Fikadu G

“…This study examines the relationship between age and neutralizing antibody titers against the SARS-CoV-2 USA-WA1/2020 strain and the P.1 variant after 2 doses…”
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Vaccination before or after SARS-CoV-2 infection leads to robust humoral response and antibodies that effectively neutralize variants by Bates, Timothy A, McBride, Savannah K, Leier, Hans C, Guzman, Gaelen, Lyski, Zoe L, Schoen, Devin, Winders, Bradie, Lee, Joon-Yong, Lee, David Xthona, Messer, William B, Curlin, Marcel E, Tafesse, Fikadu G

“…Current coronavirus disease 2019 (COVID-19) vaccines effectively reduce overall morbidity and mortality and are vitally important to controlling the pandemic…”
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Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum by Bates, Timothy A., Leier, Hans C., Lyski, Zoe L., McBride, Savannah K., Coulter, Felicity J., Weinstein, Jules B., Goodman, James R., Lu, Zhengchun, Siegel, Sarah A. R., Sullivan, Peter, Strnad, Matt, Brunton, Amanda E., Lee, David X., Adey, Andrew C., Bimber, Benjamin N., O’Roak, Brian J., Curlin, Marcel E., Messer, William B., Tafesse, Fikadu G.

“…SARS-CoV-2 and its variants continue to infect hundreds of thousands every day despite the rollout of effective vaccines. Therefore, it is essential to…”
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Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2 by Bates, Timothy A., Weinstein, Jules B., Farley, Scotland, Leier, Hans C., Messer, William B., Tafesse, Fikadu G.

“…In the ongoing coronavirus disease 2019 (COVID-19) pandemic, there remain unanswered questions regarding the nature and significance of the humoral immune…”
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A global lipid map defines a network essential for Zika virus replication by Leier, Hans C., Weinstein, Jules B., Kyle, Jennifer E., Lee, Joon-Yong, Bramer, Lisa M., Stratton, Kelly G., Kempthorne, Douglas, Navratil, Aaron R., Tafesse, Endale G., Hornemann, Thorsten, Messer, William B., Dennis, Edward A., Metz, Thomas O., Barklis, Eric, Tafesse, Fikadu G.

“…Zika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form replication sites. How ZIKV dysregulates lipid networks to allow…”
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A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants by Farley, Scotland E., Kyle, Jennifer E., Leier, Hans C., Bramer, Lisa M., Weinstein, Jules B., Bates, Timothy A., Lee, Joon-Yong, Metz, Thomas O., Schultz, Carsten, Tafesse, Fikadu G.

“…A comprehensive understanding of host dependency factors for SARS-CoV-2 remains elusive. Here, we map alterations in host lipids following SARS-CoV-2 infection…”
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Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry by Niekamp, Patrick, Guzman, Gaelen, Leier, Hans C, Rashidfarrokhi, Ali, Richina, Veronica, Pott, Fabian, Barisch, Caroline, Holthuis, Joost C M, Tafesse, Fikadu G

“…Phagocytosis by alveolar macrophages is the obligate first step in ( ) infection, yet the mechanism underlying this process is incompletely understood. Here,…”
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Ceramide synthase 2 deletion decreases the infectivity of HIV-1 by Barklis, Eric, Alfadhli, Ayna, Kyle, Jennifer E., Bramer, Lisa M., Bloodsworth, Kent J., Barklis, Robin Lid, Leier, Hans C., Petty, R. Max, Zelnik, Iris D., Metz, Thomas O., Futerman, Anthony H., Tafesse, Fikadu G.

“…The lipid composition of HIV-1 virions is enriched in sphingomyelin (SM), but the roles that SM or other sphingolipids (SLs) might play in the HIV-1…”
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Early Draper-mediated glial refinement of neuropil architecture and synapse number in the Drosophila antennal lobe by Jindal, Darren A, Leier, Hans C, Salazar, Gabriela, Foden, Alexander J, Seitz, Elizabeth A, Wilkov, Abigail J, Coutinho-Budd, Jaeda C, Broihier, Heather T

“…Glial phagocytic activity refines connectivity, though molecular mechanisms regulating this exquisitely sensitive process are incompletely defined. We…”
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An extended interval between vaccination and infection enhances hybrid immunity against SARS-CoV-2 variants by Bates, Timothy A, Leier, Hans C, McBride, Savannah K, Schoen, Devin, Lyski, Zoe L, Lee, David X, Messer, William B, Curlin, Marcel E, Tafesse, Fikadu G

“…As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be important globally. Official weekly cases have not dropped below 2 million…”
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A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants by Weinstein, Jules B., Bates, Timothy A., Leier, Hans C., McBride, Savannah K., Barklis, Eric, Tafesse, Fikadu G.

“…The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH),…”
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Sphingolipids: A double-edged sword in the defense against Mycobacterium tuberculosis by Guzman, Gaelen D, Leier, Hans, Niekamp, Patrick, Holthuis, Joost, Tafesse, Fikadu G.

“…Mycobacterium tuberculosis (Mtb) is a pathogen with a massive global health impact, and yet fundamental questions remain regarding the underlying mechanisms of…”
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Hybrid immunity and vaccine breakthrough lead to robust humoral response and antibodies that effectively neutralize SARS-CoV-2 variants by Bates, Timothy A, McBride, Savannah K, Leier, Hans C, Lyski, Zoe L, Messer, William B, Curlin, Marcel E, Tafesse, Fikadu G.

“…Current COVID-19 vaccines significantly reduce overall morbidity and mortality and are vitally important to halting the pandemic; individuals who previously…”
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Defining the roles of host lipids in flavivirus infection by Tafesse, Fikadu G., Leier, Hans C., Weinstein, Jules B., Navratil, Aaron R., Messer, William B., Dennis, Edward A., Barklis, Eric

“…The flavivirus family includes Zika virus (ZIKV), Dengue virus, West Nile virus, Japanese Encephalitis and Yellow Fever virus, each of which causes a major…”
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A global lipid map defines a network essential for Zika virus replication by Leier, Hans C., Weinstein, Jules B., Kyle, Jennifer E., Lee, Joon-Yong, Bramer, Lisa M., Stratton, Kelly G., Kempthorne, Douglas, Navratil, Aaron R., Tafesse, Endale G., Hornemann, Thorsten, Messer, William B., Dennis, Edward A., Metz, Thomas O., Barklis, Eric W., Tafesse, Fikadu G.

“…>Zika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form replication sites. How ZIKV dysregulates lipid networks to allow…”
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