Search Results - "Leiden, Jeffrey M."

Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition by Tong, Qiang, Dalgin, Gökhan, Xu, Haiyan, Ting, Chao-Nan, Leiden, Jeffrey M., Hotamisligil, Gökhan S.

“…Genes that control the early stages of adipogenesis remain largely unknown. Here, we show that murine GATA-2 and GATA-3 are specifically expressed in white…”
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Phosphorylation of Troponin I by Protein Kinase A Accelerates Relaxation and Crossbridge Cycle Kinetics in Mouse Ventricular Muscle by Kentish, Jonathan C, McCloskey, Diana T, Layland, Joanne, Palmer, Sue, Leiden, Jeffrey M, Martin, Anne F, Solaro, R John

“…ABSTRACT—Phosphorylation of cardiac myofibrils by cAMP-dependent protein kinase (PKA) can increase the intrinsic rate of myofibrillar relaxation, which may…”
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Molecular Cloning of FOG-2: A Modulator of Transcription Factor GATA-4 in Cardiomyocytes by Svensson, Eric C., Tufts, Rachel L., Polk, Christine E., Leiden, Jeffrey M.

“…GATA transcription factors are important regulators of both hematopoiesis (GATA-1/2/3) and cardiogenesis (GATA-4) in mammals. The transcriptional activities of…”
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The Ets-1 transcription factor is required for the development of natural killer cells in mice by Barton, K, Muthusamy, N, Fischer, C, Ting, C N, Walunas, T L, Lanier, L L, Leiden, J M

“…In this report we have investigated the role of the Ets-1 transcription factor in the differentiation of the NK cell lineage in mice. Splenic NK cells express…”
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Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart by Fentzke, Richard C., Buck, Scott H., Patel, Jitandrakumar R., Lin, Hua, Wolska, Beata M., Stojanovic, Miroslav O., Martin, Anne F., Solaro, R. John, Moss, Richard L., Leiden, Jeffrey M.

“…To assess the specific functions of the cardiac isoform of troponin I (cTnI), we produced transgenic mice that expressed slow skeletal troponin I (ssTnI)…”
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Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB by Barton, Kevin, Muthusamy, Natarajan, Chanyangam, Monchai, Fischer, Christopher, Clendenin, Cynthia, Leiden, Jeffrey M

“…The basic/leucine zipper (bZip) transcription factor, CREB, binds to the CRE element (TGANNTCA). The transcriptional activity of CREB requires phosphorylation…”
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Accuracy of echocardiographic estimates of left ventricular mass in mice by Collins, K A, Korcarz, C E, Shroff, S G, Bednarz, J E, Fentzke, R C, Lin, H, Leiden, J M, Lang, R M

“…Genetically modified mice have created the need for accurate noninvasive left ventricular mass (LVM) measurements. Recent technical advances provide…”
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Gene Therapy — Promise, Pitfalls, and Prognosis by Leiden, Jeffrey M

“…The application of molecular genetics to human biology has had a profound effect on our ability to understand, diagnose, and treat a variety of diseases. The…”
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Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I by Arteaga, Grace M., Palmiter, Kimberly A., Leiden, Jeffrey M., Solaro, R. John

“…We compared sarcomere length (SL) dependence of the Ca 2+ -force relation of detergent-extracted bundles of fibres dissected from the left ventricle of…”
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Inhibition of Collagen-Induced Arthritis in Mice by Viral IL-10 Gene Transfer by Ma, Yuhe, Thornton, Sherry, Duwel, Laura E, Boivin, Gregory P, Giannini, Edward H, Leiden, Jeffrey M, Bluestone, Jeffrey A, Hirsch, Raphael

“…Autoimmune arthritides are characterized by an imbalance between pro- and anti-inflammatory cytokines. Viral IL-10 (vIL-10) shares many of the…”
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Expression of slow skeletal troponin I in adult transgenic mouse heart muscle reduces the force decline observed during acidic conditions by Wolska, Beata M., Vijayan, Kalpana, Arteaga, Grace M., Konhilas, John P., Phillips, Ronald M., Kim, Robert, Naya, Taihei, Leiden, Jeffrey M., Martin, Anne F., Tombe, Pieter P., Solaro, R. John

“…Acidosis in cardiac muscle is associated with a decrease in developed force. We hypothesized that slow skeletal troponin I (ssTnI), which is expressed in…”
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An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress by Harding, Heather P., Zhang, Yuhong, Zeng, Huiquing, Novoa, Isabel, Lu, Phoebe D., Calfon, Marcella, Sadri, Navid, Yun, Chi, Popko, Brian, Paules, Richard, Stojdl, David F., Bell, John C., Hettmann, Thore, Leiden, Jeffrey M., Ron, David

“…Eukaryotic cells respond to unfolded proteins in their endoplasmic reticulum (ER stress), amino acid starvation, or oxidants by phosphorylating the α subunit…”
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p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures by Jordan, Joaquin, Galindo, Maria F, Prehn, Jochen H. M, Weichselbaum, Ralph R, Beckett, Michael, Ghadge, Ghanashyam D, Roos, Raymond P, Leiden, Jeffrey M, Miller, Richard J

“…The tumor suppressor gene p53 has been implicated in the induction of apoptosis in dividing cells. We now show that overexpression of p53 using an adenoviral…”
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Characterization of murine BATF: a negative regulator of activator protein‐1 activity in the thymus by Williams, Kristi L., Nanda, Indrajit, Lyons, Gary E., Kuo, Chay T., Schmid, Michael, Leiden, Jeffrey M., Kaplan, Mark H., Taparowsky, Elizabeth J.

“…BATF belongs to the AP‐1/ATF superfamily of transcription factors and forms heterodimers with Jun proteins to bind AP‐1 consensus DNA. Unlike Fos/Jun…”
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Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein by Wang, Chung-Yih, Petryniak, Bronislawa, Thompson, Craig B., Kaelin, William G., Leiden, Jeffrey M.

“…The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates cell cycle progression. Elf-1 is a lymphoid-specific Ets transcription factor…”
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Critical Roles for Transcription Factor GATA-3 in Thymocyte Development by Pai, Sung-Yun, Truitt, Morgan L, Ting, Chao-Nan, Leiden, Jeffrey M, Glimcher, Laurie H, Ho, I-Cheng

“…The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG…”
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Canaries, coal mines and the drug supply by Leiden, Jeffrey M

“…The heparin safety crisis sends a strong signal that urgent changes in regulatory and manufacturing oversight are needed to ensure the safety of the global…”
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Stable Delivery of Physiologic Levels of Recombinant Erythropoietin to the Systemic Circulation by Intramuscular Injection of Replication-Defective Adenovirus by Tripathy, S K, Goldwasser, E, Lu, M M, Barr, E, Leiden, J M

“…A number of inherited and acquired serum protein deficiencies including hemophilias A and B, diabetes mellitus, and the erythropoietin-responsive anemias are…”
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TRANSCRIPTIONAL REGULATION OF T LYMPHOCYTE DEVELOPMENT AND FUNCTION by Kuo, Chay T, Leiden, Jeffrey M

“…The development and function of T lymphocytes are regulated tightly by signal transduction pathways that include specific cell-surface receptors, intracellular…”
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Transcription factor LKLF is sufficient to program T cell quiescence via a c-Myc-dependent pathway by Leiden, Jeffrey M, Buckley, Anne F, Kuo, Chay T

“…T lymphocytes circulate in a quiescent state until they encounter cognate antigen bound to the surface of an antigen-presenting cell. The molecular pathways…”
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