Search Results - "Leibowitz, J"

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice by Leibowitz, Brian J., Wei, Liang, Zhang, Lin, Ping, Xiaochun, Epperly, Michael, Greenberger, Joel, Cheng, Tao, Yu, Jian

“…The role of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome is controversial. Here we use bone marrow…”
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Predicting post-treatment symptom severity for adults receiving psychological therapy in routine care for generalised anxiety disorder: a machine learning approach by Delamain, H., Buckman, J.E.J., O'Driscoll, C., Suh, J.W., Stott, J., Singh, S., Naqvi, S.A., Leibowitz, J., Pilling, S., Saunders, R.

“…Approximately half of generalised anxiety disorder (GAD) patients do not recover from first-line treatments, and no validated prediction models exist to inform…”
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Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21 by Leibowitz, Brian J, Qiu, Wei, Liu, Hongtao, Cheng, Tao, Zhang, Lin, Yu, Jian

“…The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically…”
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Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22 by Espinal, Alexis, Epperly, Michael W, Mukherjee, Amitava, Fisher, Renee, Shields, Donna, Wang, Hong, Huq, M Saiful, Hamade, Diala Fatima, Vlad, Anda M, Coffman, Lan, Buckanovich, Ronald, Yu, Jian, Leibowitz, Brian J, van Pijkeren, Jan-Peter, Patel, Ravi B, Stolz, Donna, Watkins, Simon, Ejaz, Asim, Greenberger, Joel S

“…(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by…”
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Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation by Wang, Xinwei, Wei, Liang, Cramer, Julie M., Leibowitz, Brian J., Judge, Colleen, Epperly, Michael, Greenberger, Joel, Wang, Fengchao, Li, Linheng, Stelzner, Matthias G., Dunn, James C. Y., Martin, Martin G., Lagasse, Eric, Zhang, Lin, Yu, Jian

“…Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt…”
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Group cognitive behavioural treatment for insomnia in primary care: a randomized controlled trial by Cape, J, Leibowitz, J, Whittington, C, Espie, C A, Pilling, S

“…Insomnia disorder is common and often co-morbid with mental health conditions. Cognitive behavioural therapy (CBT) for insomnia is effective, but is rarely…”
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eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis by Ruan, Hang, Li, Xiangyun, Xu, Xiang, Leibowitz, Brian J, Tong, Jingshan, Chen, Lujia, Ao, Luoquan, Xing, Wei, Luo, Jianhua, Yu, Yanping, Schoen, Robert E, Sonenberg, Nahum, Lu, Xinghua, Zhang, Lin, Yu, Jian

“…To better understand a role of eIF4E S209 in oncogenic translation, we generated heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI…”
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Obtaining a faculty position in STEM at a research-intensive institution by Vigoreaux, Jim O, Leibowitz, Michael J

“…Progressing from postdoctoral training to a STEM faculty appointment at a Research Intensive Institution (RII) is a daunting transition, and may be especially…”
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The Impact of Alcohol Use on Drop-out and Psychological Treatment Outcomes in Improving Access to Psychological Therapies Services: an Audit by Buckman, J E J, Naismith, I, Saunders, R, Morrison, T, Linke, S, Leibowitz, J, Pilling, S

“…The impact of alcohol use disorders (AUD) on psychological treatments for depression or anxiety in primary care psychological treatment services is unknown. To…”
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Characterization of Plaque-Sized Variants of Daniel’s (DA) Strain in Theiler’s Virus-Induced Epilepsy by Bijalwan, M., Young, C. R., Tingling, J., Zhou, X. J., Rimmelin, A. R., Leibowitz, J. L., Welsh, C. J.

“…Epilepsy is a complex neurological disease characterized by recurrent seizures. Patients with viral encephalitis have a 16-fold increased risk of developing…”
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Loss of Caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis by Brown, M F, Leibowitz, B J, Chen, D, He, K, Zou, F, Sobol, R W, Beer-Stolz, D, Zhang, L, Yu, J

“…Caspase-3 is the best known executioner caspase in apoptosis. We generated caspase-3 knockout (C3KO) and knockdown human colorectal cancer cells, and found…”
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Attentional Control as a Predictor of Response to Psychological Treatment for Depression and Relapse up to 1 year After Treatment: A Pilot Cohort Study by Buckman, J E J, Saunders, R, Fearon, P, Leibowitz, J, Pilling, S

“…Identifying depressed patients unlikely to reach remission and those likely to relapse after reaching remission is of great importance, but there are few…”
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Scientific Societies Advancing STEM Workforce Diversity: Lessons and Outcomes from the Minorities Affairs Committee of the American Society for Cell Biology by Segarra, Verónica A, Blatch, Sydella, Boyce, Michael, Carrero-Martinez, Franklin, Aguilera, Renato J, Leibowitz, Michael J, Zavala, MariaElena, Hammonds-Odie, Latanya, Edwards, Ashanti

“…Promoting diversity and inclusiveness in the STEM academic workforce remains a key challenge and national priority. Scientific societies can play a significant…”
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UNSEG: unsupervised segmentation of cells and their nuclei in complex tissue samples by Kochetov, Bogdan, Bell, Phoenix D., Garcia, Paulo S., Shalaby, Akram S., Raphael, Rebecca, Raymond, Benjamin, Leibowitz, Brian J., Schoedel, Karen, Brand, Rhonda M., Brand, Randall E., Yu, Jian, Zhang, Lin, Diergaarde, Brenda, Schoen, Robert E., Singhi, Aatur, Uttam, Shikhar

“…Multiplexed imaging technologies have made it possible to interrogate complex tissue microenvironments at sub-cellular resolution within their native spatial…”
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Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer by Ruan, Hang, Leibowitz, Brian J., Peng, Yingpeng, Shen, Lin, Chen, Lujia, Kuang, Charlie, Schoen, Robert E., Lu, Xinghua, Zhang, Lin, Yu, Jian

“…Mutant KRAS is a key driver in colorectal cancer (CRC) and promotes Myc translation and Myc-dependent stress adaptation and proliferation. Here, we report that…”
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γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue by Orenstein, Alexander, Berlyoung, April S, Rastede, Elizabeth E, Pham, Ha H, Fouquerel, Elise, Murphy, Connor T, Leibowitz, Brian J, Yu, Jian, Srivastava, Tumul, Armitage, Bruce A, Opresko, Patricia L

“…Measurement of telomere length by fluorescent in situ hybridization is widely used for biomedical and epidemiological research, but there has been relatively…”
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Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells by Leibowitz, Brian J., Cohick, Wendie S.

“…TNF‐α and IGF‐I exert opposing effects on mammary epithelial cell (MEC) growth and survival. However, both increase IGF binding protein‐3 (IGFBP‐3) expression,…”
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Immunogenic cell death in colon cancer prevention and therapy by Ruan, Hang, Leibowitz, Brian J., Zhang, Lin, Yu, Jian

“…Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune…”
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The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK by Neely, R J, Brose, M S, Gray, C M, McCorkell, K A, Leibowitz, J M, Ma, C, Rothstein, J L, May, M J

“…The oncogenic fusion protein RET/PTC3 (RP3) that is expressed in papillary thyroid carcinoma (PTC) and thyroid epithelia in Hashimoto's thyroiditis activates…”
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A hydrogel prepared by in situ cross-linking of a thiol-containing poly(ethylene glycol)-based copolymer: a new biomaterial for protein drug delivery by Qiu, Bo, Stefanos, Simon, Ma, Jianglin, Lalloo, Anita, Perry, Barbara A., Leibowitz, Michael J., Sinko, Patrick J., Stein, Stanley

“…A new poly(ethylene glycol)-based copolymer containing multiple thiol (–SH) groups was cross-linked in situ to form a polymer hydrogel under mild conditions…”
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