Search Results - "Leibowitz, Brian J."

Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice by Leibowitz, Brian J., Wei, Liang, Zhang, Lin, Ping, Xiaochun, Epperly, Michael, Greenberger, Joel, Cheng, Tao, Yu, Jian

“…The role of bone marrow (BM) and BM-derived cells in radiation-induced acute gastrointestinal (GI) syndrome is controversial. Here we use bone marrow…”
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Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21 by Leibowitz, Brian J, Qiu, Wei, Liu, Hongtao, Cheng, Tao, Zhang, Lin, Yu, Jian

“…The role of p53 in tissue protection is not well understood. Loss of p53 blocks apoptosis in the intestinal crypts following irradiation but paradoxically…”
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Intestinal Radiation Protection and Mitigation by Second-Generation Probiotic Lactobacillus-reuteri Engineered to Deliver Interleukin-22 by Espinal, Alexis, Epperly, Michael W, Mukherjee, Amitava, Fisher, Renee, Shields, Donna, Wang, Hong, Huq, M Saiful, Hamade, Diala Fatima, Vlad, Anda M, Coffman, Lan, Buckanovich, Ronald, Yu, Jian, Leibowitz, Brian J, van Pijkeren, Jan-Peter, Patel, Ravi B, Stolz, Donna, Watkins, Simon, Ejaz, Asim, Greenberger, Joel S

“…(1) Background: The systemic administration of therapeutic agents to the intestine including cytokines, such as Interleukin-22 (IL-22), is compromised by…”
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Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation by Wang, Xinwei, Wei, Liang, Cramer, Julie M., Leibowitz, Brian J., Judge, Colleen, Epperly, Michael, Greenberger, Joel, Wang, Fengchao, Li, Linheng, Stelzner, Matthias G., Dunn, James C. Y., Martin, Martin G., Lagasse, Eric, Zhang, Lin, Yu, Jian

“…Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt…”
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eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis by Ruan, Hang, Li, Xiangyun, Xu, Xiang, Leibowitz, Brian J, Tong, Jingshan, Chen, Lujia, Ao, Luoquan, Xing, Wei, Luo, Jianhua, Yu, Yanping, Schoen, Robert E, Sonenberg, Nahum, Lu, Xinghua, Zhang, Lin, Yu, Jian

“…To better understand a role of eIF4E S209 in oncogenic translation, we generated heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI…”
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UNSEG: unsupervised segmentation of cells and their nuclei in complex tissue samples by Kochetov, Bogdan, Bell, Phoenix D., Garcia, Paulo S., Shalaby, Akram S., Raphael, Rebecca, Raymond, Benjamin, Leibowitz, Brian J., Schoedel, Karen, Brand, Rhonda M., Brand, Randall E., Yu, Jian, Zhang, Lin, Diergaarde, Brenda, Schoen, Robert E., Singhi, Aatur, Uttam, Shikhar

“…Multiplexed imaging technologies have made it possible to interrogate complex tissue microenvironments at sub-cellular resolution within their native spatial…”
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Targeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer by Ruan, Hang, Leibowitz, Brian J., Peng, Yingpeng, Shen, Lin, Chen, Lujia, Kuang, Charlie, Schoen, Robert E., Lu, Xinghua, Zhang, Lin, Yu, Jian

“…Mutant KRAS is a key driver in colorectal cancer (CRC) and promotes Myc translation and Myc-dependent stress adaptation and proliferation. Here, we report that…”
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Immunogenic cell death in colon cancer prevention and therapy by Ruan, Hang, Leibowitz, Brian J., Zhang, Lin, Yu, Jian

“…Colorectal cancer (CRC) is a leading cause of cancer‐related death worldwide. The colonic mucosa constitutes a critical barrier and a major site of immune…”
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γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue by Orenstein, Alexander, Berlyoung, April S, Rastede, Elizabeth E, Pham, Ha H, Fouquerel, Elise, Murphy, Connor T, Leibowitz, Brian J, Yu, Jian, Srivastava, Tumul, Armitage, Bruce A, Opresko, Patricia L

“…Measurement of telomere length by fluorescent in situ hybridization is widely used for biomedical and epidemiological research, but there has been relatively…”
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Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells by Leibowitz, Brian J., Cohick, Wendie S.

“…TNF‐α and IGF‐I exert opposing effects on mammary epithelial cell (MEC) growth and survival. However, both increase IGF binding protein‐3 (IGFBP‐3) expression,…”
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Targeting Myc-driven stress addiction in colorectal cancer by Saeed, Haris, Leibowitz, Brian J., Zhang, Lin, Yu, Jian

“…MYC is a proto-oncogene that encodes a powerful regulator of transcription and cellular programs essential for normal development, as well as the growth and…”
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Inhibition of CDK4/6 protects against radiation-induced intestinal injury in mice by Wei, Liang, Leibowitz, Brian J, Wang, Xinwei, Epperly, Michael, Greenberger, Joel, Zhang, Lin, Yu, Jian

“…Radiotherapy causes dose-limiting toxicity and long-term complications in rapidly renewing tissues, including the gastrointestinal tract. Currently, there is…”
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mTOR inhibition suppresses Myc-driven polyposis by inducing immunogenic cell death by Leibowitz, Brian J., Zhao, Guangyi, Xia, Wenxin, Wang, Yuhan, Ruan, Hang, Zhang, Lin, Yu, Jian

“…Myc is a key driver of colorectal cancer initiation and progression, but remains a difficult drug target. In this study, we show that mTOR inhibition potently…”
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Non-steroidal anti-inflammatory drugs induce immunogenic cell death in suppressing colorectal tumorigenesis by Fletcher, Rochelle, Tong, Jingshan, Risnik, Denise, Leibowitz, Brian J., Wang, Yi-Jun, Concha-Benavente, Fernando, DeLiberty, Jonathan M., Stolz, Donna B., Pai, Reet K., Ferris, Robert L., Schoen, Robert E., Yu, Jian, Zhang, Lin

“…Use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal cancer (CRC). However, the mechanism by which NSAIDs…”
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FAK Drives Resistance to Therapy in HPV-Negative Head and Neck Cancer in a p53-Dependent Manner by Pifer, Phillip M, Yang, Liangpeng, Kumar, Manish, Xie, Tongxin, Frederick, Mitchell, Hefner, Andrew, Beadle, Beth, Molkentine, David, Molkentine, Jessica, Dhawan, Annika, Abdelhakiem, Mohamed, Osman, Abdullah A, Leibowitz, Brian J, Myers, Jeffrey N, Pickering, Curtis R, Sandulache, Vlad C, Heymach, John, Skinner, Heath D

“…Radiation and platinum-based chemotherapy form the backbone of therapy in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). We…”
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Targeting p53-dependent stem cell loss for intestinal chemoprotection by Leibowitz, Brian J, Yang, Liheng, Wei, Liang, Buchanan, Monica E, Rachid, Madani, Parise, Robert A, Beumer, Jan H, Eiseman, Julie L, Schoen, Robert E, Zhang, Lin, Yu, Jian

“…The gastrointestinal (GI) epithelium is the fastest renewing adult tissue and is maintained by tissue-specific stem cells. Treatment-induced GI side effects…”
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The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice by Wei, Liang, Leibowitz, Brian J., Epperly, Michael, Bi, Cheng, Li, Allen, Steinman, Justin, Wipf, Peter, Li, Song, Zhang, Lin, Greenberger, Joel, Yu, Jian

“…Total body irradiation (TBI) leads to dose- and tissue-specific lethality. In the current study, we demonstrate that a mitochondrion-targeted nitroxide JP4-039…”
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Lactobacillus reuteri Releasing IL-22 (LR-IL-22) Facilitates Intestinal Radioprotection for Whole-Abdomen Irradiation (WAI) of Ovarian Cancer by Hamade, Diala F., Espinal, Alexis, Yu, Jian, Leibowitz, Brian J., Fisher, Renee, Hou, Wen, Shields, Donna, van Pijkeren, Jan-Peter, Mukherjee, Amitava, Epperly, Michael W., Vlad, Anda M., Coffman, Lan, Wang, Hong, Saiful Huq, M., Patel, Ravi, Huang, Jason, Greenberger, Joel S.

“…Oral administration (gavage) of a second-generation probiotic, Lactobacillus reuteri (L. reuteri), that releases interleukin-22 (LR-IL-22) at 24 h after…”
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Interferon b drives intestinal regeneration after radiation by Leibowitz, Brian J, Zhao, Guangyi, Wei, Liang, Ruan, Hang, Epperly, Michael, Chen, Lujia, Lu, Xinghua, Greenberger, Joel S, Zhang, Lin, Yu, Jian

“…The cGAS-STING cytosolic DNA sensing pathway is critical for host defense. Here, we report that cGAS-STING–dependent type 1 interferon (IFN) response drives…”
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Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation by Zhang, Xichen, Fisher, Renee, Hou, Wen, Shields, Donna, Epperly, Michael W, Wang, Hong, Wei, Liang, Leibowitz, Brian J, Yu, Jian, Alexander, Laura M, VAN Pijkeren, Jan-Peter, Watkins, Simon, Wipf, Peter, Greenberger, Joel S

“…Intestinal damage induced by total body irradiation (TBI) reduces leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells,…”
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