Search Results - "Leibel, R"

Molecular physiology of weight regulation in mice and humans by Leibel, R L

“…Evolutionary considerations relating to efficiency in reproduction, and survival in hostile environments, suggest that body energy stores are sensed and…”
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Adaptive thermogenesis in humans by Rosenbaum, M, Leibel, R L

“…The increasing prevalence of obesity and its comorbidities reflects the interaction of genes that favor the storage of excess energy as fat with an environment…”
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Metabolically healthy and unhealthy obese – the 2013 Stock Conference report by Samocha‐Bonet, D, Dixit, V. D, Kahn, C. R, Leibel, R. L, Lin, X, Nieuwdorp, M, Pietiläinen, K. H, Rabasa‐Lhoret, R, Roden, M, Scherer, P. E, Klein, S, Ravussin, E

“…Obesity is closely associated with cardiovascular diseases and type 2 diabetes, but some obese individuals, despite having excessive body fat, exhibit…”
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Estimating energy expenditure in mice using an energy balance technique by Ravussin, Y, Gutman, R, LeDuc, C A, Leibel, R L

“…Objective: To compare, in mice, the accuracy of estimates of energy expenditure (EE) using an energy balance technique (TEE bal : food energy intake and body…”
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Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin by Wakae-Takada, N., Xuan, S., Watanabe, K., Meda, P., Leibel, R. L.

“…Aims/hypothesis In rodents and humans, the rate of beta cell proliferation declines rapidly after birth; formation of the islets of Langerhans begins…”
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Genetic association analysis of 30 genes related to obesity in a European American population by Li, P, Tiwari, H K, Lin, W-Y, Allison, D B, Chung, W K, Leibel, R L, Yi, N, Liu, N

“…OBJECTIVE: Obesity, which is frequently associated with diabetes, hypertension and cardiovascular diseases, is primarily the result of a net excess of caloric…”
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Epigenetic regulation of serotonin transporter expression and behavior in infant rhesus macaques by Kinnally, E. L., Capitanio, J. P., Leibel, R., Deng, L., LeDuc, C., Haghighi, F., Mann, J. J.

“…Epigenetic mechanisms may moderate genetic and environmental risk (G×E) for mood disorders. We used an experimental rhesus macaque model of early life stress…”
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Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) by Demmer, R.T., Trinh, P., Rosenbaum, M., Li, G., LeDuc, C., Leibel, R., González, A., Knight, R., Paster, B., Colombo, P.C., Desvarieux, M., Papapanou, P.N., Jacobs, D.R.

“…Microbial communities along mucosal surfaces throughout the digestive tract are hypothesized as risk factors for impaired glucose regulation and the…”
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Proteasome inhibitors, including curcumin, improve pancreatic β-cell function and insulin sensitivity in diabetic mice by Weisberg, S, Leibel, R, Tortoriello, D V

“…Background: Type 2 diabetes stems from obesity-associated insulin resistance, and in the genetically susceptible, concomitant pancreatic β-cell failure can…”
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Determination of the half-life of circulating leptin in the mouse by Burnett, L C, Skowronski, A A, Rausch, R, LeDuc, C A, Leibel, R L

“…Background: The adipokine hormone, leptin, is a major component of body weight homeostasis. Numerous studies have been performed administering recombinant…”
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Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function by ROSENBAUM, M, HIRSCH, J, MURPHY, E, LEIBEL, R. L

“…Weight gain and loss increases and decreases energy expenditure, respectively, out of proportion to changes in metabolic mass. We hypothesized that changes in…”
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Effects of chronic weight perturbation on energy homeostasis and brain structure in mice by Ravussin, Y, Gutman, R, Diano, S, Shanabrough, M, Borok, E, Sarman, B, Lehmann, A, LeDuc, C A, Rosenbaum, M, Horvath, T L, Leibel, R L

“…Maintenance of reduced body weight in lean and obese human subjects results in the persistent decrease in energy expenditure below what can be accounted for by…”
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Leptin Regulation of Agrp and Npy mRNA in the Rat Hypothalamus by Korner, J., Savontaus, E., Chua Jr, S. C., Leibel, R. L., Wardlaw, S. L.

“…Agouti‐related protein (AGRP) is synthesized in the same neurones in the arcuate nucleus as neuropeptide Y (NPY), another potent orexigenic peptide. AGRP…”
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Effects of gender, body composition, and menopause on plasma concentrations of leptin by ROSENBAUM, M, NICHOLSON, M, HIRSCH, J, HEYMSFIELD, S. B, GALLAGHER, D, CHU, F, LEIBEL, R. L

“…Circulating concentrations of leptin ([leptin]) vary directly with body mass index and percentage body fat, and may thus constitute an afferent limb of a…”
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Neurofunctional imaging of β-cell dynamics by Harris, P. E., Leibel, R. L.

“…Here, we outline how islet cells use autocrine and paracrine ‘circuits’ of classical neurotransmitters and their corresponding receptors and transporters to…”
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Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults by MATSUOKA, N, PATKI, A, TIWARI, H. K, ALLISON, D. B, JOHNSON, S. B, GREGERSEN, P. K, LEIBEL, R. L, CHUNG, W. K

“…To test for association of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) K121Q polymorphism with body mass index (BMI) and diabetes in a large…”
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VMAT2 quantitation by PET as a biomarker for β-cell mass in health and disease by Freeby, M, Goland, R, Ichise, M, Maffei, A, Leibel, R, Harris, P

“…The common pathology underlying both type 1 and type 2 diabetes (T1DM and T2DM) is insufficient β-cell mass (BCM) to meet metabolic demands. An important…”
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Phenotypes of Mouse Diabetes and Rat Fatty Due to Mutations in the OB (Leptin) Receptor by Chua, Streamson C., Chung, Wendy K., Wu-Peng, X. Sharon, Zhang, Yiying, Liu, Shun-Mei, Tartaglia, Louis, Leibel, Rudolph L.

“…Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and…”
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Effects of weight change on plasma leptin concentrations and energy expenditure by ROSENBAUM, M, NICOLSON, M, HIRSCH, J, MURPHY, E, CHU, F, LEIBEL, R. L

“…Circulating concentrations of leptin are closely correlated with body fat mass, and may thus constitute an afferent limb of a system regulating body fatness,…”
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Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset? by Ravussin, Y, LeDuc, C.A, Watanabe, K, Mueller, B.R, Skowronski, A, Rosenbaum, M, Leibel, R.L

“…Abstract Circulating leptin concentrations correlate with fat mass and signal the status of somatic energy stores to the brain. Previous studies suggest that…”
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