Search Results - "Lei, Zuhai"

Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection by Lei, Zuhai, Zhang, Fan

“…The development of fluorophores for the second near‐infrared window (NIR‐II, 1000–1700 nm) represents an emerging, significant, and vibrant field in analytic…”
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The pursuit of polymethine fluorophores with NIR-II emission and high brightness for in vivo applications by Zhao, Xuan, Zhang, Fan, Lei, Zuhai

“…Polymethine cyanine dyes, as the most important class of organic near-infrared-II (NIR-II) fluorophores, recently received increasing attention due to their…”
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Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing by Wang, Shangfeng, Fan, Yong, Li, Dandan, Sun, Caixia, Lei, Zuhai, Lu, Lingfei, Wang, Ting, Zhang, Fan

“…The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window…”
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An Efficient 1064 nm NIR‐II Excitation Fluorescent Molecular Dye for Deep‐Tissue High‐Resolution Dynamic Bioimaging by Li, Benhao, Lu, Lingfei, Zhao, Mengyao, Lei, Zuhai, Zhang, Fan

“…A small‐molecule fluorophore FD‐1080 with both excitation and emission in the NIR‐II region has been successfully synthesized for in vivo imaging. A…”
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ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing by Zhang, Xin, Chen, Ying, He, Haisheng, Wang, Shangfeng, Lei, Zuhai, Zhang, Fan

“…Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline…”
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A Promising NIR‐II Fluorescent Sensor for Peptide‐Mediated Long‐Term Monitoring of Kidney Dysfunction by Chen, Ying, Pei, Peng, Lei, Zuhai, Zhang, Xin, Yin, Dongrui, Zhang, Fan

“…Kidney disease is usually “silent” at the early stage but can lead to severe kidney failure later on. The development of bioimaging probes with rapid…”
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NIR‐II pH Sensor with a FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization by Zhao, Mengyao, Wang, Jianbo, Lei, Zuhai, Lu, Lingfei, Wang, Shangfeng, Zhang, Hongxin, Li, Benhao, Zhang, Fan

“…Monitoring the pH in tumor lesions provides abundant physiological information. However, currently developed pH sensors only achieve sensitive detection in the…”
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Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing by Lei, Zuhai, Sun, Caixia, Pei, Peng, Wang, Shangfeng, Li, Dandan, Zhang, Xin, Zhang, Fan

“…Small‐molecule organic fluorophores, spectrally active in the 900–1700 nm region, with tunable wavelength and sensing properties are sought‐after for in vivo…”
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Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring by Li, Dandan, Wang, Shangfeng, Lei, Zuhai, Sun, Caixia, El-Toni, Ahmed Mohamed, Alhoshan, Mansour Saleh, Fan, Yong, Zhang, Fan

“…Drug-induced hepatotoxicity represents an important challenge for safety in drug development. The production of peroxynitrite (ONOO–) is proposed as an early…”
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Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near‐Infrared Spectral Region by Lei, Zuhai, Li, Xinran, Luo, Xiao, He, Haihong, Zheng, Jing, Qian, Xuhong, Yang, Youjun

“…Small‐molecule organic fluorophores spectrally active in the 800–950 nm region are sought‐after for their broad potential in biomedical and material…”
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Recent Advances in Intraoperative Nerve Bioimaging: Fluorescence‐Guided Surgery for Nerve Preservation by Chen, Ying, Zhang, Hongxin, Lei, Zuhai, Zhang, Fan

“…Accidental transection or injury of nerves during surgeries leads to severe patient morbidity and lowers the life quality of patients. The current imaging…”
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NIR-II cell endocytosis-activated fluorescent probes for in vivo high-contrast bioimaging diagnostics by He, Yue, Wang, Shangfeng, Yu, Peng, Yan, Kui, Ming, Jiang, Yao, Chenzhi, He, Zuyang, El-Toni, Ahmed Mohamed, Khan, Aslam, Zhu, Xinyan, Sun, Caixia, Lei, Zuhai, Zhang, Fan

“…Fluorescence probes have great potential to empower bioimaging, precision clinical diagnostics and surgery. However, current probes are limited to in vivo…”
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A diversity-oriented rhodamine library for wide-spectrum bactericidal agents with low inducible resistance against resistant pathogens by Luo, Xiao, Qian, Liujia, Xiao, Yansheng, Tang, Yao, Zhao, Yang, Wang, Xia, Gu, Luyan, Lei, Zuhai, Bao, Jianming, Wu, Jiahui, He, Tingting, Hu, Fupin, Zheng, Jing, Li, Honglin, Zhu, Weiping, Shao, Lei, Dong, Xiaojing, Chen, Daijie, Qian, Xuhong, Yang, Youjun

“…Antimicrobial resistance is a public health emergency and warrants coordinated global efforts. Challenge is that no alternative molecular platform has been…”
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Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection by Lei, Zuhai, Zhang, Fan

“…The development of fluorophores for the second near‐infrared window (NIR‐II, 1000–1700 nm) represents an emerging, significant, and vibrant field in analytic…”
Get full text

Unsymmetrical pentamethine cyanines for visualizing physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescence by Wang, Yicheng, Lei, Zuhai, Wang, Cong, Cao, Chong, Hu, Jiayi, Du, Ling, Han, Limei, Li, Cong

“…Acidity plays an important role in numerous physiological and pathological events. Non-invasively monitoring pH dynamics would be valuable for understanding…”
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A Ratiometric Sers Probe for Imaging the Macrophage Phenotypes in Live Mice with Epilepsy and Brain Tumor by Duan, Wenjia, Wang, Cong, Jiang, Yiqing, Sui, An, Li, Zhi, Wang, Lu, Lei, Zuhai, Aime, Silvio, Yu, Jinhua, Li, Cong

“…Macrophage performs multiple functions such as pathogen phagocytosis, antigen presentation and tissue remodeling by polarizing toward a spectrum of phenotypes…”
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A Reversible NIR‐II Ratiometric Fluorescent Probe for Real‐Time In Vivo ATP Detection by Liu, Yunyi, Zhang, Lu, Chen, Ying, Sun, Haitao, Chen, Jiajian, El‐Toni, Ahmed Mohamed, Khan, Aslam, Lei, Zuhai, Zhang, Fan

“…ATP plays a prominent role in shaping the evolution of immune cell responses to injury, infection, and cancer. However, real‐time monitoring of ATP levels in…”
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A novel chromogenic and fluorogenic scaffold for detection of oxidative radicals by Lei, Zuhai, Zeng, Zhenhua, Qian, Xuhong, Yang, Youjun

“…Radical detection has attracted significant attention recently. Here we have developed a scaffold through covalent assembly principle（OR570）, which could…”
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Spectral and biodistributional engineering of deep near-infrared chromophore by Dong, Yan, Lu, Xicun, Li, Yi, Chen, Weichao, Yin, Lei, Zhao, Jie, Hu, Xinru, Li, Xinran, Lei, Zuhai, Wu, Yuyang, Chen, Hao, Luo, Xiao, Qian, Xuhong, Yang, Youjun

“…Fluorescence-guided surgery calls for development of near-infrared fluorophores. Despite the wide-spread application and a safe clinical record of Indocyanine…”
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ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing by Zhang, Xin, Chen, Ying, He, Haisheng, Wang, Shangfeng, Lei, Zuhai, Zhang, Fan

“…Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive nitrogen species (RNS) not only in acidic tissue but also in alkaline…”
Get full text