Search Results - "Lei, Ruipeng"

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing by Wang, Yiquan, Lei, Ruipeng, Nourmohammad, Armita, Wu, Nicholas C

“…As one of the main influenza antigens, neuraminidase (NA) in H3N2 virus has evolved extensively for more than 50 years due to continuous immune pressure. While…”
Get full text

Analysis of ethics dumping and proposed solutions in the field of biomedical research in China by Liao, Bohua, Ma, Yonghui, Lei, Ruipeng

“…As international academic exchanges and cooperation deepen, China has actively engaged in international biomedical research collaboration and achieved…”
Get full text

A leap of faith: building the trust in human biobanks by Zhang, Yi, Liao, Bohua, Lei, Ruipeng

“…Background: Human biobanks are an essential resource for contemporary medical research, crucial in treating and preventing human diseases and improving health…”
Get full text

Some remarks on the argument appealing to nature against synthetic biology by Lei, Ruipeng, Peng, Yifan, He, Yutian, Li, Jun

“…This paper will focus on analyzing the argument with appealing to nature against synthetic biology and provide a counter-argument against it through…”
Get full text

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike by Tan, Timothy J. C., Mou, Zongjun, Lei, Ruipeng, Ouyang, Wenhao O., Yuan, Meng, Song, Ge, Andrabi, Raiees, Wilson, Ian A., Kieffer, Collin, Dai, Xinghong, Matreyek, Kenneth A., Wu, Nicholas C.

“…Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with…”
Get full text

Mutational fitness landscape of human influenza H3N2 neuraminidase by Lei, Ruipeng, Hernandez Garcia, Andrea, Tan, Timothy J.C., Teo, Qi Wen, Wang, Yiquan, Zhang, Xiwen, Luo, Shitong, Nair, Satish K., Peng, Jian, Wu, Nicholas C.

“…Influenza neuraminidase (NA) has received increasing attention as an effective vaccine target. However, its mutational tolerance is not well characterized…”
Get full text

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning by Lei, Ruipeng, Qing, Enya, Odle, Abby, Yuan, Meng, Gunawardene, Chaminda D., Tan, Timothy J. C., So, Natalie, Ouyang, Wenhao O., Wilson, Ian A., Gallagher, Tom, Perlman, Stanley, Wu, Nicholas C., Wong, Lok-Yin Roy

“…The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope…”
Get full text

Mutational fitness landscape of human influenza H3N2 neuraminidase by Lei, Ruipeng, Hernandez Garcia, Andrea, Tan, Timothy J.C., Teo, Qi Wen, Wang, Yiquan, Zhang, Xiwen, Luo, Shitong, Nair, Satish K., Peng, Jian, Wu, Nicholas C.

Get full text

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem by Teo, Qi Wen, Wang, Yiquan, Lv, Huibin, Tan, Timothy J.C., Lei, Ruipeng, Mao, Kevin J., Wu, Nicholas C.

“…IGHV1-69 is frequently utilized by broadly neutralizing influenza antibodies to the hemagglutinin (HA) stem. These IGHV1-69 HA stem antibodies have diverse…”
Get full text

Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin by Lei, Ruipeng, Liang, Weiwen, Ouyang, Wenhao O., Hernandez Garcia, Andrea, Kikuchi, Chika, Wang, Shengyang, McBride, Ryan, Tan, Timothy J. C., Sun, Yuanxin, Chen, Chunke, Graham, Claire S., Rodriguez, Lucia A., Shen, Ivana R., Choi, Danbi, Bruzzone, Roberto, Paulson, James C., Nair, Satish K., Mok, Chris K. P., Wu, Nicholas C.

“…The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe…”
Get full text

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase by Lei, Ruipeng, Tan, Timothy J. C., Hernandez Garcia, Andrea, Wang, Yiquan, Diefenbacher, Meghan, Teo, Chuyun, Gopan, Gopika, Tavakoli Dargani, Zahra, Teo, Qi Wen, Graham, Claire S., Brooke, Christopher B., Nair, Satish K., Wu, Nicholas C.

“…Neuraminidase (NA) of human influenza H3N2 virus has evolved rapidly and been accumulating mutations for more than half-century. However, biophysical…”
Get full text

Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses by Daulagala, Pavithra, Mann, Brian R, Leung, Kathy, Lau, Eric H Y, Yung, Louise, Lei, Ruipeng, Nizami, Sarea I N, Wu, Joseph T, Chiu, Susan S, Daniels, Rodney S, Wu, Nicholas C, Wentworth, David, Peiris, Malik, Yen, Hui-Ling

“…Immune imprinting is a driver known to shape the anti-hemagglutinin (HA) antibody landscape of individuals born within the same birth cohort. With the HA and…”
Get full text

Ethical framework on risk governance of synthetic biology by Bohua, Liao, Yuexin, Wang, Yakun, Ou, Kunlan, Zuo, Huan, Liu, Ruipeng, Lei

“…Synthetic biology is an emerging multidisciplinary field that aims to design and construct new biological systems not found in nature. Whereas synthetic…”
Get full text

The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro by Li, Xun, Su, Juan, Fang, Rui, Zheng, Lucheng, Lei, Ruipeng, Wang, Xiaoye, Lei, Zhihai, Jin, Mengmeng, Jiao, Yang, Hou, Yuanlong, Guo, Tingting, Ma, Zhiyu

“…•RFRP-3 inhibit GnRH release and expression.•Inhibitory effect of RFRP-3 on gonadotropin secretion and the expression of gonadotropin gene subunits.•Inhibitory…”
Get full text

Modulation of trinucleotide repeat instability by DNA polymerase β polymorphic variant R137Q by Ren, Yaou, Lai, Yanhao, Laverde, Eduardo E, Lei, Ruipeng, Rein, Hayley L, Liu, Yuan

“…Trinucleotide repeat (TNR) instability is associated with human neurodegenerative diseases and cancer. Recent studies have pointed out that DNA base excision…”
Get full text

Regulation and management of the biosecurity for synthetic biology by Zeng, Xiaomei, Jiang, Hailun, Yang, Guangying, Ou, Yakun, Lu, Shan, Jiang, Jia, Lei, Ruipeng, Su, Li

“…Synthetic biology (SynBio) is a high-profile interdiscipline combining engineering with science. As a dual-purpose discipline, SynBio is bringing large changes…”
Get full text

Top five ethical lessons of COVID-19 that the world must learn by Smith, Maxwell J, Ahmad, Aasim, Arawi, Thalia, Dawson, Angus, Emanuel, Ezekiel J, Garani-Papadatos, T, Ghimire, Prakash, Iliyasu, Zubairu, Lei, Ruipeng, Mastroleo, Ignacio, Mathur, Roli, Okeibunor, Joseph, Parker, Michael, Saenz, Carla, Thomé, Beatriz, Upshur, Ross E G, Voo, Teck Chuan

“…As the world reflects upon one year since the first cases of coronavirus disease 2019 (COVID-19) and prepare for and experience surges in cases, it is…”
Get full text

Ethical and regulatory issues in human gene editing: Chinese perspective by Lei, Ruipeng, Qiu, Renzong

“…This paper focuses on the ethical and regulatory issues raised by gene editing. In the introduction of this paper, authors provide the background where the…”
Get full text

A Strategy to Prevent and Control Zoonoses? by Lei, Ruipeng, Qiu, Renzong

“…The authors argue that in preventing and controlling the pandemic of Covid‐19, we should have taken an offensive or proactive strategy rather than a defensive…”
Get full text

Reboot ethics governance in China by Lei, Ruipeng, Zhai, Xiaomei, Zhu, Wei, Qiu, Renzong

“…The shocking announcement of genetically modified babies creates an opportunity to overhaul the nation’s science, argue Ruipeng Lei and colleagues. The…”
Get full text