Search Results - "Lei, P"

Function and regulation of chromatin insulators in dynamic genome organization by Chen, Dahong, Lei, Elissa P

“…•CTCF and cohesin are required for genome-wide organization of TADs.•TADs and compartments are not hierarchical forms of chromatin organization.•Strong…”
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Widespread Rearrangement of 3D Chromatin Organization Underlies Polycomb-Mediated Stress-Induced Silencing by Li, Li, Lyu, Xiaowen, Hou, Chunhui, Takenaka, Naomi, Nguyen, Huy Q., Ong, Chin-Tong, Cubeñas-Potts, Caelin, Hu, Ming, Lei, Elissa P., Bosco, Giovanni, Qin, Zhaohui S., Corces, Victor G.

“…Chromosomes of metazoan organisms are partitioned in the interphase nucleus into discrete topologically associating domains (TADs). Borders between TADs are…”
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IoT-based real-time production logistics synchronization system under smart cloud manufacturing by Qu, T., Lei, S. P., Wang, Z. Z., Nie, D. X., Chen, X., Huang, George Q.

“…Cloud manufacturing (CM) and Internet of things (IoT) are interlinked, yet most works only focused on one of them and take the other as a constituent…”
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Tau-mediated iron export prevents ferroptotic damage after ischemic stroke by Tuo, Q-z, Lei, P, Jackman, K A, Li, X-l, Xiong, H, Li, X-l, Liuyang, Z-y, Roisman, L, Zhang, S-t, Ayton, S, Wang, Q, Crouch, P J, Ganio, K, Wang, X-c, Pei, L, Adlard, P A, Lu, Y-m, Cappai, R, Wang, J-z, Liu, R, Bush, A I

“…Functional failure of tau contributes to age-dependent, iron-mediated neurotoxicity, and as iron accumulates in ischemic stroke tissue, we hypothesized that…”
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Transposable element landscapes in aging Drosophila by Yang, Nachen, Srivastav, Satyam P, Rahman, Reazur, Ma, Qicheng, Dayama, Gargi, Li, Sizheng, Chinen, Madoka, Lei, Elissa P, Rosbash, Michael, Lau, Nelson C

“…Genetic mechanisms that repress transposable elements (TEs) in young animals decline during aging, as reflected by increased TE expression in aged animals…”
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Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture by Cubeñas-Potts, Caelin, Rowley, M Jordan, Lyu, Xiaowen, Li, Ge, Lei, Elissa P, Corces, Victor G

“…Eukaryotic gene expression is regulated by enhancer-promoter interactions but the molecular mechanisms that govern specificity have remained elusive…”
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M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity by Bag, Indira, Chen, Shue, Rosin, Leah F., Chen, Yang, Liu, Chen-Yu, Yu, Guo-Yun, Lei, Elissa P.

“…Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear…”
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3D genome organization by Silahtaroglu, Asli, Bridger, Joanna M., Lei, Elissa P.

“…Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds…”
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Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species by Hockens, Clio, Lorenzi, Hernan, Wang, Tricia T, Lei, Elissa P, Rosin, Leah F

“…Precise regulation of chromosome dynamics in the germline is essential for reproductive success across species. Yet, the mechanisms underlying meiotic…”
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Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori by Rosin, Leah F, Gil, Jose, Drinnenberg, Ines A, Lei, Elissa P

“…Accurate chromosome segregation during meiosis is essential for reproductive success. Yet, many fundamental aspects of meiosis remain unclear, including the…”
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CT findings of adrenal schwannoma by Zhang, Y.-m, Lei, P.-f, Chen, M.-n, Lv, X.-f, Ling, Y.-h, Cai, P.-q, Gao, J.-m

“…Aim To analyse the computed tomography (CT) imaging features of patients with adrenal schwannoma. Materials and methods Eight cases of adrenal schwannoma…”
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Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling by Chen, Dahong, McManus, Catherine E., Radmanesh, Behram, Matzat, Leah H., Lei, Elissa P.

“…During development, looping of an enhancer to a promoter is frequently observed in conjunction with temporal and tissue-specific transcriptional activation…”
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HP1 recruitment in the absence of argonaute proteins in Drosophila by Moshkovich, Nellie, Lei, Elissa P

“…Highly repetitive and transposable element rich regions of the genome must be stabilized by the presence of heterochromatin. A direct role for RNA interference…”
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Advances in tumor markers of ovarian cancer for early diagnosis by Dong, X, Men, X, Zhang, W, Lei, P

“…Ovarian cancer often occurs in perimenopausal women. The mortality of ovarian cancer is in the first place among gynecological cancers because of no obvious…”
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NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization by Chen, Shue, Rosin, Leah F, Pegoraro, Gianluca, Moshkovich, Nellie, Murphy, Patrick J, Yu, Guoyun, Lei, Elissa P

“…Abstract Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers and…”
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hsa_circ_0121582 inhibits leukemia growth by dampening Wnt/β-catenin signaling by Chen, J-J., Lei, P., Zhou, M.

“…Purpose The prognosis of AML patients with chemotherapy is poor, especially those who are insensitive to and resistant to chemotherapy drugs. To clarify the…”
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Syntheses, Properties, and Aggregation Behavior of Novel Carboxylate‐Based Silicone Surfactants by Meng, Lina, Wang, Wenyu, Li, A. P. Lei, Feng, Shengyu

“…Two new anionic silicone surfactants were synthesized for the first time from dichloromethylvinylsilane or trichlorovinylsilane through hydrolysis‐condensation…”
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Lithium suppression of tau induces brain iron accumulation and neurodegeneration by Lei, P, Ayton, S, Appukuttan, A T, Moon, S, Duce, J A, Volitakis, I, Cherny, R, Wood, S J, Greenough, M, Berger, G, Pantelis, C, McGorry, P, Yung, A, Finkelstein, D I, Bush, A I

“…Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand tremor, often limit its use…”
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Resveratrol induces apoptosis of pancreatic cancers cells by inhibiting miR-21 regulation of BCL-2 expression by Liu, P., Liang, H., Xia, Q., Li, P., Kong, H., Lei, P., Wang, S., Tu, Z.

“…Objective Resveratrol is an edible polyphenolic phytoalexin present in different plant species and plays important role in inhibiting proliferation and…”
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Effects of the Reynolds Number on the Efficiency and Stall Mechanisms in a Three-stage Axial Compressor by Zhou, E, Lei, P, Fan, C, Zhang, W, Liu, K, Cheng, S

“…The Reynolds number (Re) is an important parameter that can affect compressor performance. This study experimentally and numerically investigated the effect of…”
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