Search Results - "Lei, Martina Mang Leng"
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The interplay of UBE2T and Mule in regulating Wnt/β-catenin activation to promote hepatocellular carcinoma progression
Published in Cell death & disease (01-02-2021)“…Emerging evidence indicates the role of cancer stem cells (CSCs) in tumor relapse and therapeutic resistance in patients with hepatocellular carcinoma (HCC)…”
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Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers
Published in Frontiers in cell and developmental biology (21-06-2021)“…Cancer stem cells (CSCs) are subpopulations of undifferentiated cancer cells within the tumor bulk that are responsible for tumor initiation, recurrence and…”
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Broad-spectrum kinome profiling identifies CDK6 upregulation as a driver of lenvatinib resistance in hepatocellular carcinoma
Published in Nature communications (23-10-2023)“…Increasing evidence has demonstrated that drug resistance can be acquired in cancer cells by kinase rewiring, which is an obstacle for efficient cancer…”
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NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma
Published in Cancer letters (28-04-2020)“…Solid evidence shows that tumor-initiating cells (T-ICs) are the root of tumor relapse and drug resistance, which lead to a poor prognosis in patients with…”
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EPHB2 Activates β-Catenin to Enhance Cancer Stem Cell Properties and Drive Sorafenib Resistance in Hepatocellular Carcinoma
Published in Cancer research (Chicago, Ill.) (15-06-2021)“…The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer…”
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Reply to correspondence regarding "UBE2S: A novel driver of HIF-1alpha-induced metabolic reprogramming in hepatocellular carcinoma
Published in Clinical and molecular hepatology (05-08-2024)Get full text
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UBE2S: A novel driver of HIF-1alpha-induced metabolic reprogramming in hepatocellular carcinoma
Published in Clinical and molecular hepatology (23-07-2024)Get full text
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Caspase-3–Induced Activation of SREBP2 Drives Drug Resistance via Promotion of Cholesterol Biosynthesis in Hepatocellular Carcinoma
Published in Cancer research (Chicago, Ill.) (02-09-2022)“…Abstract Accumulating evidence has demonstrated that drug resistance can be acquired in cancer through the repopulation of tumors by cancer stem cell (CSC)…”
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SCYL3, as a novel binding partner and regulator of ROCK2, promotes hepatocellular carcinoma progression
Published in JHEP reports (01-01-2023)“…SCY1-like pseudokinase 3 (SCYL3) was identified as a binding partner of ezrin, implicating it in metastasis. However, the clinical relevance and functional…”
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