Search Results - "Lei, Jianlin"

Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex by Yan, Renhong, Zhao, Xin, Lei, Jianlin, Zhou, Qiang

“…The L-type amino acid transporter 1 (LAT1; also known as SLC7A5) catalyses the cross-membrane flux of large neutral amino acids in a sodium- and pH-independent…”
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Recognition of the amyloid precursor protein by human γ-secretase by Zhou, Rui, Yang, Guanghui, Guo, Xuefei, Zhou, Qiang, Lei, Jianlin, Shi, Yigong

“…Cleavage of amyloid precursor protein (APP) by the intramembrane protease γ-secretase is linked to Alzheimer's disease (AD). We report an atomic structure of…”
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Structural basis for the recognition of Sonic Hedgehog by human Patched1 by Gong, Xin, Qian, Hongwu, Cao, Pingping, Zhao, Xin, Zhou, Qiang, Lei, Jianlin, Yan, Nieng

“…The Hedgehog (Hh) pathway involved in development and regeneration is activated by the extracellular binding of Hh to the membrane receptor Patched (Ptch). We…”
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Structure of a human catalytic step I spliceosome by Zhan, Xiechao, Yan, Chuangye, Zhang, Xiaofeng, Lei, Jianlin, Shi, Yigong

“…Splicing by the spliceosome involves branching and exon ligation. The branching reaction leads to the formation of the catalytic step I spliceosome (C…”
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Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins by Shen Huaizong, Liu Dongliang, Wu, Kun, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structure of the Human Lipid Exporter ABCA1 by Qian, Hongwu, Zhao, Xin, Cao, Pingping, Lei, Jianlin, Yan, Nieng, Gong, Xin

“…ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor…”
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The architecture of the mammalian respirasome by Gu, Jinke, Wu, Meng, Guo, Runyu, Yan, Kaige, Lei, Jianlin, Gao, Ning, Yang, Maojun

“…The respiratory chain complexes I, III and IV (CI, CIII and CIV) are present in the bacterial membrane or the inner mitochondrial membrane and have a role of…”
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Structure of the human PKD1-PKD2 complex by Su, Qiang, Hu, Feizhuo, Ge, Xiaofei, Lei, Jianlin, Yu, Shengqiang, Wang, Tingliang, Zhou, Qiang, Mei, Changlin, Shi, Yigong

“…Mutations in two genes, and , account for most cases of autosomal dominant polycystic kidney disease, one of the most common monogenetic disorders. Here we…”
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Structure and mechanogating of the mammalian tactile channel PIEZO2 by Wang, Li, Zhou, Heng, Zhang, Mingmin, Liu, Wenhao, Deng, Tuan, Zhao, Qiancheng, Li, Yiran, Lei, Jianlin, Li, Xueming, Xiao, Bailong

“…PIEZO2 is a mechanosensitive cation channel that has a key role in sensing touch, tactile pain, breathing and blood pressure. Here we describe the…”
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Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates by Wang, Nan, Jiang, Xin, Zhang, Shuo, Zhu, Angqi, Yuan, Yafei, Xu, Hanwen, Lei, Jianlin, Yan, Chuangye

“…Proton-coupled monocarboxylate transporters MCT1-4 catalyze the transmembrane movement of metabolically essential monocarboxylates and have been targeted for…”
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Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution by Fan, Xiao, Wang, Jia, Zhang, Xing, Yang, Zi, Zhang, Jin-Can, Zhao, Lingyun, Peng, Hai-Lin, Lei, Jianlin, Wang, Hong-Wei

“…The fast development of single-particle cryogenic electron microscopy (cryo-EM) has made it more feasible to obtain the 3D structure of well-behaved…”
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Structural basis for the modulation of voltage-gated sodium channels by animal toxins by Shen, Huaizong, Li, Zhangqiang, Jiang, Yan, Pan, Xiaojing, Wu, Jianping, Cristofori-Armstrong, Ben, Smith, Jennifer J, Chin, Yanni K Y, Lei, Jianlin, Zhou, Qiang, King, Glenn F, Yan, Nieng

“…Animal toxins that modulate the activity of voltage-gated sodium (Na ) channels are broadly divided into two categories-pore blockers and gating modifiers. The…”
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Structures of the human spliceosomes before and after release of the ligated exon by Zhang, Xiaofeng, Zhan, Xiechao, Yan, Chuangye, Zhang, Wenyu, Liu, Dongliang, Lei, Jianlin, Shi, Yigong

“…Pre-mRNA splicing is executed by the spliceosome, which has eight major functional states each with distinct composition. Five of these eight human…”
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Structure of the Nav1.4-β1 Complex from Electric Eel by Yan, Zhen, Zhou, Qiang, Wang, Lin, Wu, Jianping, Zhao, Yanyu, Huang, Gaoxingyu, Peng, Wei, Shen, Huaizong, Lei, Jianlin, Yan, Nieng

“…Voltage-gated sodium (Nav) channels initiate and propagate action potentials. Here, we present the cryo-EM structure of EeNav1.4, the Nav channel from electric…”
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Structure of the human activated spliceosome in three conformational states by Zhang, Xiaofeng, Yan, Chuangye, Zhan, Xiechao, Li, Lijia, Lei, Jianlin, Shi, Yigong

“…During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (B act complex), which has a…”
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Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA by Pan Xiaojing, Li Zhangqiang, Huang Xiaoshuang, Huang Gaoxingyu, Gao Shuai, Shen Huaizong, Liu, Lei, Lei Jianlin, Nieng, Yan

“…Targeting sodium channelsVoltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these…”
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Structures of the human pre-catalytic spliceosome and its precursor spliceosome by Zhan, Xiechao, Yan, Chuangye, Zhang, Xiaofeng, Lei, Jianlin, Shi, Yigong

“…The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (B act complex)…”
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Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel by Zhao, Yanyu, Huang, Gaoxingyu, Wu, Jianping, Wu, Qiurong, Gao, Shuai, Yan, Zhen, Lei, Jianlin, Yan, Nieng

“…The L-type voltage-gated Ca2+ (Cav) channels are modulated by various compounds exemplified by 1,4-dihydropyridines (DHP), benzothiazepines (BTZ), and…”
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Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 by Pan Xiaojing, Li Zhangqiang, Zhou, Qiang, Shen Huaizong, Wu, Kun, Huang Xiaoshuang, Chen Jiaofeng, Zhang Juanrong, Zhu Xuechen, Lei Jianlin, Xiong, Wei, Gong Haipeng, Xiao Bailong, Nieng, Yan

“…Structures of voltage-gated sodium channelsIn “excitable” cells, like neurons and muscle cells, a difference in electrical potential is used to transmit…”
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An Atomic Structure of the Human Spliceosome by Zhang, Xiaofeng, Yan, Chuangye, Hang, Jing, Finci, Lorenzo I., Lei, Jianlin, Shi, Yigong

“…Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron…”
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