Search Results - "Lehvaslaiho, H"

The Ensembl genome database project by Hubbard, T, Barker, D, Birney, E, Cameron, G, Chen, Y, Clark, L, Cox, T, Cuff, J, Curwen, V, Down, T, Durbin, R, Eyras, E, Gilbert, J, Hammond, M, Huminiecki, L, Kasprzyk, A, Lehvaslaiho, H, Lijnzaad, P, Melsopp, C, Mongin, E, Pettett, R, Pocock, M, Potter, S, Rust, A, Schmidt, E, Searle, S, Slater, G, Smith, J, Spooner, W, Stabenau, A, Stalker, J, Stupka, E, Ureta-Vidal, A, Vastrik, I, Clamp, M

“…The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organise biology around the sequences of large genomes. It is a…”
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Ensembl 2002: accommodating comparative genomics by Clamp, M., Andrews, D., Barker, D., Bevan, P., Cameron, G., Chen, Y., Clark, L., Cox, T., Cuff, J., Curwen, V., Down, T., Durbin, R., Eyras, E., Gilbert, J., Hammond, M., Hubbard, T., Kasprzyk, A., Keefe, D., Lehvaslaiho, H., Iyer, V., Melsopp, C., Mongin, E., Pettett, R., Potter, S., Rust, A., Schmidt, E., Searle, S., Slater, G., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Stupka, E., Ureta-Vidal, A., Vastrik, I., Birney, E.

“…The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organise biology around the sequences of large genomes. It is a…”
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Ensembl 2004 by Birney, E., Andrews, D., Bevan, P., Caccamo, M., Cameron, G., Chen, Y., Clarke, L., Coates, G., Cox, T., Cuff, J., Curwen, V., Cutts, T., Down, T., Durbin, R., Eyras, E., Fernandez‐Suarez, X. M., Gane, P., Gibbins, B., Gilbert, J., Hammond, M., Hotz, H., Iyer, V., Kahari, A., Jekosch, K., Kasprzyk, A., Keefe, D., Keenan, S., Lehvaslaiho, H., McVicker, G., Melsopp, C., Meidl, P., Mongin, E., Pettett, R., Potter, S., Proctor, G., Rae, M., Searle, S., Slater, G., Smedley, D., Smith, J., Spooner, W., Stabenau, A., Stalker, J., Storey, R., Ureta‐Vidal, A., Woodwark, C., Clamp, M., Hubbard, T.

“…The Ensembl (http://www.ensembl.org/) database project provides a bioinformatics framework to organize biology around the sequences of large genomes. It is a…”
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Recommendations for locus-specific databases and their curation by Cotton, R.G.H, Auerbach, A.D, Beckmann, J.S, Blumenfeld, O.O, Brookes, A.J, Brown, A.F, Carrera, P, Cox, D.W, Gottlieb, B, Greenblatt, M.S, Hilbert, P, Lehvaslaiho, H, Liang, P, Marsh, S, Nebert, D.W, Povey, S, Rossetti, S, Scriver, C.R, Summar, M, Tolan, D.R, Verma, I.C, Vihinen, M, den Dunnen, J.T

“…Expert curation and complete collection of mutations in genes that affect human health is essential for proper genetic healthcare and research. Expert curation…”
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structured simple form for ordering genetic tests is needed to ensure coupling of clinical detail (phenotype) with DNA variants (genotype) to ensure utility in publication and databases by Cotton, R.G.H, Auerbach, A.D, Brown, A.F, Carrera, P, Christodoulou, J, Claustres, M, Compton, J, Cox, D.W, De Baere, E, den Dunnen, J.T, Greenblatt, M, Fujiwara, M, Hilbert, P, Jani, A, Lehvaslaiho, H, Nebert, D.W, Verma, I, Vihinen, M

“…Researchers and clinicians ideally need instant access to all the variation in their gene/locus of interest to efficiently conduct their research and genetic…”
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Human sequence variation and mutation databases by Lehvaslaiho, H.

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Distribution and genetic heterogeneity of Puumala virus in Sweden by Horling, Jan, Lundkvist, Ake, Jaarola, Maarit, Plyusnin, Alexander, Tegelstrom, Hakan, Persson, Katarina, Lehvaslaiho, Heikki, Hornfeldt, Birger, Vaheri, Antti, Niklasson, Bo

“…1 Swedish Institute for Infectious Disease Control, S-105 21 Stockholm, Sweden 2 Microbiology and Tumour Biology Centre, Karolinska Institute, S-171 77…”
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A chimeric EGF‐R‐neu proto‐oncogene allows EGF to regulate neu tyrosine kinase and cell transformation by Lehväslaiho, H., Lehtola, L., Sistonen, L., Alitalo, K.

“…The neu oncogene, characterized by Weinberg and colleagues, is a transforming gene found in ethylnitrosourea‐induced rat neuro/glioblastomas; its human…”
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Sequences of wild Puumala virus genes show a correlation of genetic variation with geographic origin of the strains by Plyusnin, Alexander, Vapalahti, Olli, Ulfves, Kristian, Lehvaslaiho, Heikki, Apekina, Natalia, Gavrilovskaya, Irene, Blinov, Vladimir, Vaheri, Antti

“…1 Department of Virology, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), FIN-00014 Helsinki, Finland, 2 Research Institute of Poliomyelitis and Viral…”
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HGVbase: a curated resource describing human DNA variation and phenotype relationships by Fredman, D., Munns, G., Rios, D., Sjöholm, F., Siegfried, M., Lenhard, B., Lehväslaiho, H., Brookes, A. J.

“…The Human Genome Variation Database (HGVbase; http://hgvbase.cgb.ki.se) has provided a curated summary of human DNA variation for more than 5 years, thus…”
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HGVbase: a human sequence variation database emphasizing data quality and a broad spectrum of data sources by Fredman, D, Siegfried, M, Yuan, Y P, Bork, P, Lehväslaiho, H, Brookes, A J

“…HGVbase (Human Genome Variation database; http://hgvbase.cgb.ki.se, formerly known as HGBASE) is an academic effort to provide a high quality and non-redundant…”
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Activation of the neu Tyrosine Kinase Induces the fos/jun Transcription Factor Complex, the Glucose Transporter, and Ornithine Decarboxylase by Sistonen, Lea, Hölttä, Erkki, Lehväslaiho, Heikki, Lehtola, Laura, Alitalo, Kari

“…We have studied the ability of the neu tyrosine kinase to induce a signal for the activation of cell growth-regulated genes. Serum-starved NIH 3T3 cells…”
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BTKbase, mutation database for X-linked agammaglobulinemia (XLA) by Vihinen, Mauno, Belohradsky, Bernd H., Haire, Robert N., Holinski-Feder, Elke, Kwan, Sau-Ping, Lappalainen, Ilkka, Lehväslaiho, Heikki, Lester, Tracy, Meindl, Alfons, Ochs, Hans D., Ollila, Juha, Vorechovsky, Igor, Weiss, Michael, Smith, C. I. Edvard

“…X-linked agammaglobulinemia (XLA) is an immunodeficiency caused by mutations in the gene coding for Bruton's agammaglobulinemia tyrosine kinase (BTK). A…”
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Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure by Aittomäki, Kristiina, Dieguez Lucena, JoséLuis, Pakarinen, Pirjo, Sistonen, Pertti, Tapanainen, Juha, Gromoll, Jörg, Kaskikari, Riitta, Sankila, Eeva-Marja, Lehväslaiho, Heikki, Reyes Engel, Armando, Nieschlag, Eberhard, Huhtaniemi, Ilpo, de la Chapelle, Albert

“…Hypergonadotropic ovarian dysgenesis (ODG) with normal karyotype is a heterogeneous condition that in some cases displays Mendelian recessive inheritance. By…”
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The Bioperl toolkit: Perl modules for the life sciences by Stajich, Jason E, Block, David, Boulez, Kris, Brenner, Steven E, Chervitz, Stephen A, Dagdigian, Chris, Fuellen, Georg, Gilbert, James G R, Korf, Ian, Lapp, Hilmar, Lehväslaiho, Heikki, Matsalla, Chad, Mungall, Chris J, Osborne, Brian I, Pocock, Matthew R, Schattner, Peter, Senger, Martin, Stein, Lincoln D, Stupka, Elia, Wilkinson, Mark D, Birney, Ewan

“…The Bioperl project is an international open-source collaboration of biologists, bioinformaticians, and computer scientists that has evolved over the past 7 yr…”
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Tula virus: a newly detected hantavirus carried by European common voles by Plyusnin, A, Vapalahti, O, Lankinen, H, Lehväslaiho, H, Apekina, N, Myasnikov, Y, Kallio-Kokko, H, Henttonen, H, Lundkvist, A, Brummer-Korvenkontio, M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activation of an EGFR/neu chimeric receptor: early intracellular signals and cell proliferation responses by Pandiella, A, Lehvaslaiho, H, Magni, M, Alitalo, K, Meldolesi, J

“…Two clones of NIH3T3 fibroblasts, NEN37 and NEN7, overexpressing chimeric EGF/neu receptors (3 x 10(5) and 1 x 10(6) receptors/cell, respectively), were…”
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HGBASE: a database of SNPs and other variations in and around human genes by Brookes, A J, Lehväslaiho, H, Siegfried, M, Boehm, J G, Yuan, Y P, Sarkar, C M, Bork, P, Ortigao, F

“…Human genome polymorphism is expected to play a key role in defining the etiologic basis of phenotypic differences between individuals in aspects such as drug…”
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Guidelines and recommendations for content, structure, and deployment of mutation databases by Scriver, C.R., Nowacki, P.M., Lehväslaiho, H.

“…These Guidelines recognize the need for annotated online mutation databases documenting allelic variation (both pathogenic and phenotype modifying, and also…”
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A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein by Lehtola, L, Lehväslaiho, H, Koskinen, P, Alitalo, K

“…As the factor binding to the neu protein has been unknown, it has not been possible to confirm experimentally the proposed growth-factor receptor like…”
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