Search Results - "Lehto, VP"

Mesoporous silicon microparticles for oral drug delivery: Loading and release of five model drugs by Salonen, J., Laitinen, L., Kaukonen, A.M., Tuura, J., Björkqvist, M., Heikkilä, T., Vähä-Heikkilä, K., Hirvonen, J., Lehto, V.-P.

“…Mesoporous silicon (PSi) microparticles were produced using thermal carbonization (TCPSi) or thermal oxidation (TOPSi) to obtain surfaces suitable for oral…”
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Cytotoxicity of mesoporous silicon microparticles with different surface modifications on ARPE‐19 cells by KORHONEN, E, RIIKONEN, J, XU, W, LEHTO, VP, KAUPPINEN, A

“…Purpose Retinal pigment epithelial (RPE) cells play a crucial role in the pathogenesis of age‐related macular degeneration (AMD). However, RPE is a challenging…”
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Binding of GGA2 to the Lysosomal Enzyme Sorting Motif of the Mannose 6-Phosphate Receptor by Zhu, Yunxiang, Doray, Balraj, Poussu, Anssi, Lehto, Veli-Pekka, Kornfeld, Stuart

“…The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to…”
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Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targeting by Falasca, M., Logan, S.K., Lehto, V.P., Baccante, G., Lemmon, M.A., Schlessinger, J.

“…Signaling via growth factor receptors frequently results in the concomitant activation of phospholipase Cγ (PLCγ) and phosphatidylinositol (PI) 3‐kinase. While…”
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Histopathological Evaluation of Apoptosis in Cancer by Soini, Y., Pääkkö, P., Lehto, V-P.

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Effect of particle morphology on the triboelectrification in dry powder inhalers by Murtomaa, Matti, Mellin, Velipekka, Harjunen, Päivi, Lankinen, Tapio, Laine, Ensio, Lehto, Vesa-Pekka

“…Electrostatic charge of lactoses of different particle morphology and amorphous contents were measured during actuation from two different dry powder inhalers…”
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Depth profiling of compression-induced disorders and polymorphic transition on tablet surfaces with grazing incidence X-ray diffraction by KOIVISTO, Mikko, HEINÄNEN, Paula, TANNINEN, Veli Pekka, LEHTO, Vesa-Pekka

“…The importance of induced crystal disorders like crystallite size, crystal defects, and amorphicity with respect to the dissolution rate of the drug has been…”
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Use of thermoanalytical methods in quantification of drug load in mesoporous silicon microparticles by LEHTO, V.-P, VÄHÄ-HEIKKILÄ, K, PASKI, J, SALONEN, J

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Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function by Vainionpää, Noora, Lehto, Veli-Pekka, Tryggvason, Karl, Virtanen, Ismo

“…Laminin (Lm) α4 chain, a constituent of Lm-411 and Lm-421, is mainly localized to mesenchyme-derived tissues, and is suggested to have a role in formation and…”
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Mutations in the Human UDP- N-Acetylglucosamine 2-Epimerase Gene Define the Disease Sialuria and the Allosteric Site of the Enzyme by Seppala, Raili, Lehto, Veli-Pekka, Gahl, William A.

“…Sialuria is a rare inborn error of metabolism characterized by cytoplasmic accumulation and increased urinary excretion of free N-acetylneuraminic acid (NeuAc,…”
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A European network for virtual microscopy—design, implementation and evaluation of performance by Lundin, Mikael, Szymas, Janusz, Linder, Ewert, Beck, Hans, de Wilde, Peter, van Krieken, Han, García Rojo, Marcial, Moreno, Ignacio, Ariza, Aurelio, Tuzlali, Sitki, Dervişoğlu, Sergülen, Helin, Heikki, Lehto, Veli-Pekka, Lundin, Johan

“…Web-based virtual microscopy has enabled new applications within pathology. Here, we introduce and evaluate a network of academic servers, designed to maximize…”
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Normalization of nomenclature for peptide motifs as ligands of modular protein domains by Aasland, Rein, Abrams, Charles, Ampe, Christophe, Ball, Linda J., Bedford, Mark T., Cesareni, Gianni, Gimona, Mario, Hurley, James H., Jarchau, Thomas, Lehto, Veli-Pekka, Lemmon, Mark A., Linding, Rune, Mayer, Bruce J., Nagai, Makoto, Sudol, Marius, Walter, Ulrich, Winder, Steve J.

“…We propose a normalization of symbols and terms used to describe, accurately and succinctly, the detailed interactions between amino acid residues of pairs of…”
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Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers by Tarvainen, Maarit, Sutinen, Riitta, Peltonen, Soili, Mikkonen, Hannu, Maunus, Jaana, Vähä-Heikkilä, Kalle, Lehto, Vesa-Pekka, Paronen, Petteri

“…Purpose: The aim of this study was to investigate the ability of n-alkenyl succinic anhydrides ( n-ASAs) to improve the film-forming characteristics of a novel…”
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One-pot citral transformation to menthol over bifunctional micro- and mesoporous metal modified catalysts: Effect of catalyst support and metal by Mäki-Arvela, Päivi, Kumar, Narendra, Kubička, David, Nasir, Ali, Heikkilä, Teemu, Lehto, Vesa-Pekka, Sjöholm, Rainer, Salmi, Tapio, Murzin, Dmitry Yu

“…Citral transformation to menthols was conducted in liquid phase over Ni supported H-MCM-41 and H-Y. The highest selectivity to four different stereoisomers of…”
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Sub-ppm trace moisture detection with a simple thermally carbonized porous silicon sensor by Salonen, J., Tuura, J., Björkqvist, M., Lehto, V.-P.

“…A simple humidity sensor based on thermally carbonized porous silicon has been used to detect low moisture contents in gaseous atmosphere. Thermal…”
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VHS domain – a longshoreman of vesicle lines by Lohi, Olli, Poussu, Anssi, Mao, Yuxin, Quiocho, Florante, Lehto, Veli-Pekka

“…The VHS ( V ps-27, H rs and S TAM) domain is a 140 residue long domain present in the very NH 2-terminus of at least 60 proteins. Based on their functional…”
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STAM/EAST/Hbp adapter proteins – integrators of signalling pathways by Lohi, Olli, Lehto, Veli-Pekka

“…STAM/EAST/Hbp family of proteins consists of eight members well conserved from yeast to mammals. The basic domain architecture is comprised of an N-terminal…”
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Effects of carriers and storage of formulation on the lung deposition of a hydrophobic and hydrophilic drug from a DPI by Harjunen, Päivi, Lankinen, Tapio, Salonen, Heikki, Lehto, Vesa-Pekka, Järvinen, Kristiina

“…The effects of carriers, the drug:carrier ratio and a 1 month storage period of a formulation in permeable polystyrene tube at 40 °C/75% RH on the in vitro…”
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Water adsorption on plasma sprayed transition metal oxides by Harju, Mika, Mäntylä, Tapio, Vähä-Heikkilä, Kalle, Lehto, Vesa-Pekka

“…The aim of this study was to characterize water adsorption on plasma sprayed chromia and titania coatings. Both materials are widely used in industry as wear…”
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Determination of drug load in porous silicon microparticles by calorimetry by Salonen, J., Paski, J., Vähä-Heikkilä, K., Heikkilä, T., Björkqvist, M., Lehto, V.-P.

“…Different kind of drugs can be loaded into the porous silicon microparticles for oral dosing. In cases where the drug is in its crystalline form in the pores,…”
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