Search Results - "Lehtinen, Maria K."

Development and functions of the choroid plexus–cerebrospinal fluid system by Lun, Melody P., Monuki, Edwin S., Lehtinen, Maria K.

“…Key Points The choroid plexus (ChP) is a secretory tissue found in each of the brain ventricles, the main function of which is to produce cerebrospinal fluid…”
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The Cerebrospinal Fluid Provides a Proliferative Niche for Neural Progenitor Cells by Lehtinen, Maria K., Zappaterra, Mauro W., Chen, Xi, Yang, Yawei J., Hill, Anthony D., Lun, Melody, Maynard, Thomas, Gonzalez, Dilenny, Kim, Seonhee, Ye, Ping, D'Ercole, A. Joseph, Wong, Eric T., LaMantia, Anthony S., Walsh, Christopher A.

“…Cortical development depends on the active integration of cell-autonomous and extrinsic cues, but the coordination of these processes is poorly understood…”
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The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond by Zappaterra, Mauro W., Lehtinen, Maria K.

“…The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances…”
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Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models by Orefice, Lauren L., Mosko, Jacqueline R., Morency, Danielle T., Wells, Michael F., Tasnim, Aniqa, Mozeika, Shawn M., Ye, Mengchen, Chirila, Anda M., Emanuel, Alan J., Rankin, Genelle, Fame, Ryann M., Lehtinen, Maria K., Feng, Guoping, Ginty, David D.

“…Somatosensory over-reactivity is common among patients with autism spectrum disorders (ASDs) and is hypothesized to contribute to core ASD behaviors. However,…”
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Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation by Cui, Jin, Shipley, Frederick B., Shannon, Morgan L., Alturkistani, Osama, Dani, Neil, Webb, Mya D., Sugden, Arthur U., Andermann, Mark L., Lehtinen, Maria K.

“…The choroid plexus (ChP) regulates brain development by secreting instructive cues and providing a protective brain barrier. Here, we show that…”
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Experimental approaches for manipulating choroid plexus epithelial cells by Jang, Ahram, Lehtinen, Maria K

“…Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal fluid barrier (BCSFB) in the developing and mature brain. The ChP…”
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Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development by Xu, Huixin, Fame, Ryann M., Sadegh, Cameron, Sutin, Jason, Naranjo, Christopher, Della Syau, Cui, Jin, Shipley, Frederick B., Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Warf, Benjamin C., Lin, Pei-Yi, Lehtinen, Maria K.

“…Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal…”
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Neurogenesis at the Brain-Cerebrospinal Fluid Interface by Lehtinen, Maria K, Walsh, Christopher A

“…Cerebral cortical progenitor cells can be classified into several different types, and each progenitor type integrates cell-intrinsic and cell-extrinsic cues…”
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The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy by Lehtinen, Maria K, Bjornsson, Christopher S, Dymecki, Susan M, Gilbertson, Richard J, Holtzman, David M, Monuki, Edwin S

“…Although universally recognized as the source of cerebrospinal fluid (CSF), the choroid plexus (ChP) has been one of the most understudied tissues in…”
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Progressive Differentiation and Instructive Capacities of Amniotic Fluid and Cerebrospinal Fluid Proteomes following Neural Tube Closure by Chau, Kevin F., Springel, Mark W., Broadbelt, Kevin G., Park, Hye-yeon, Topal, Salih, Lun, Melody P., Mullan, Hillary, Maynard, Thomas, Steen, Hanno, LaMantia, Anthony S., Lehtinen, Maria K.

“…After neural tube closure, amniotic fluid (AF) captured inside the neural tube forms the nascent cerebrospinal fluid (CSF). Neuroepithelial stem cells contact…”
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Tracking Calcium Dynamics and Immune Surveillance at the Choroid Plexus Blood-Cerebrospinal Fluid Interface by Shipley, Frederick B., Dani, Neil, Xu, Huixin, Deister, Christopher, Cui, Jin, Head, Joshua P., Sadegh, Cameron, Fame, Ryann M., Shannon, Morgan L., Flores, Vanessa I., Kishkovich, Thomas, Jang, Emily, Klein, Eric M., Goldey, Glenn J., He, Kangmin, Zhang, Yong, Holtzman, Michael J., Kirchhausen, Tomas, Wyart, Claire, Moore, Christopher I., Andermann, Mark L., Lehtinen, Maria K.

“…The choroid plexus (ChP) epithelium is a source of secreted signaling factors in cerebrospinal fluid (CSF) and a key barrier between blood and brain. Here, we…”
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Somatic Activation of AKT3 Causes Hemispheric Developmental Brain Malformations by Poduri, Annapurna, Evrony, Gilad D., Cai, Xuyu, Elhosary, Princess Christina, Beroukhim, Rameen, Lehtinen, Maria K., Hills, L. Benjamin, Heinzen, Erin L., Hill, Anthony, Hill, R. Sean, Barry, Brenda J., Bourgeois, Blaise F.D., Riviello, James J., Barkovich, A. James, Black, Peter M., Ligon, Keith L., Walsh, Christopher A.

“…Hemimegalencephaly (HMG) is a developmental brain disorder characterized by an enlarged, malformed cerebral hemisphere, typically causing epilepsy that…”
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Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers by Cheong, Taek-Chin, Jang, Ahram, Wang, Qi, Leonardi, Giulia C., Ricciuti, Biagio, Alessi, Joao V., Di Federico, Alessandro, Awad, Mark M., Lehtinen, Maria K., Harris, Marian H., Chiarle, Roberto

“…Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes…”
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Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production by Lun, Melody P, Johnson, Matthew B, Broadbelt, Kevin G, Watanabe, Momoko, Kang, Young-Jin, Chau, Kevin F, Springel, Mark W, Malesz, Alexandra, Sousa, André M M, Pletikos, Mihovil, Adelita, Tais, Adelita, Tai, Calicchio, Monica L, Zhang, Yong, Holtzman, Michael J, Lidov, Hart G W, Sestan, Nenad, Steen, Hanno, Monuki, Edwin S, Lehtinen, Maria K

“…A sheet of choroid plexus epithelial cells extends into each cerebral ventricle and secretes signaling factors into the CSF. To evaluate whether differences in…”
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In utero intracerebroventricular delivery of adeno-associated viral vectors to target mouse choroid plexus and cerebrospinal fluid by Jang, Ahram, Lehtinen, Maria K.

“…Experimentally targeting mouse choroid plexus (ChP) provides a valuable approach for investigating mechanisms of ChP-cerebrospinal fluid (CSF) biology. Here,…”
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Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling by Yuan, Zengqiang, Lehtinen, Maria K., Merlo, Paola, Villén, Judit, Gygi, Steven, Bonni, Azad

“…The protein kinase mammalian Sterile 20-like kinase 1 (MST1) plays a critical role in the regulation of cell death. Recent studies suggest that MST1 mediates…”
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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution by Fame, Ryann M., Kalugin, Peter N., Petrova, Boryana, Xu, Huixin, Soden, Paul A., Shipley, Frederick B., Dani, Neil, Grant, Bradford, Pragana, Aja, Head, Joshua P., Gupta, Suhasini, Shannon, Morgan L., Chifamba, Fortunate F., Hawks-Mayer, Hannah, Vernon, Amanda, Gao, Fan, Zhang, Yong, Holtzman, Michael J., Heiman, Myriam, Andermann, Mark L., Kanarek, Naama, Lipton, Jonathan O., Lehtinen, Maria K.

“…Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can modulate brain states via regulation of cerebrospinal fluid (CSF)…”
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Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway by Chang, Jessica T., Lehtinen, Maria K., Sive, Hazel

“…ABSTRACT Cerebrospinal fluid (CSF) includes conserved factors whose function is largely unexplored. To assess the role of CSF during embryonic development, CSF…”
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Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis by Fame, Ryann M, Lehtinen, Maria K

“…Function of the mature central nervous system (CNS) requires a substantial proportion of the body's energy consumption. During development, the CNS anlage must…”
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A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span by Lehtinen, Maria K., Yuan, Zengqiang, Boag, Peter R., Yang, Yue, Villén, Judit, Becker, Esther B.E., DiBacco, Sara, de la Iglesia, Núria, Gygi, Steven, Blackwell, T. Keith, Bonni, Azad

“…Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated…”
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