Search Results - "Lehtimäki, Terho"

MicroRNAs in the atherosclerotic plaque by Raitoharju, Emma, Oksala, Niku, Lehtimäki, Terho

“…MicroRNAs (miRNA, miR) are noncoding RNAs that regulate gene expression by hindering translation. miRNA expression profiles have been shown to differ in vivo…”
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Circulating microRNAs as biomarkers in progressive multiple sclerosis by Vistbakka, Julia, Elovaara, Irina, Lehtimäki, Terho, Hagman, Sanna

“…Background: In multiple sclerosis (MS), microRNA (miRNA) dysregulation is mostly reported in different immune cells, but less information is available on…”
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C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis by Park, Inhye, Goddard, Michael E., Cole, Jennifer E., Zanin, Natacha, Lyytikäinen, Leo-Pekka, Lehtimäki, Terho, Andreakos, Evangelos, Feldmann, Marc, Udalova, Irina, Drozdov, Ignat, Monaco, Claudia

“…Macrophages are integral to the pathogenesis of atherosclerosis, but the contribution of distinct macrophage subsets to disease remains poorly defined. Using…”
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Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults by WÜRTZ, Peter, SOININEN, Pasi, KANGAS, Antti J, RÖNNEMAA, Tapani, LEHTIMÄKI, Terho, KAHONEN, Mika, VIIKARI, Jorma S, RAITAKARI, Olli T, ALA-KORPELA, Mika

“…Branched-chain and aromatic amino acids are associated with the risk for future type 2 diabetes; however, the underlying mechanisms remain elusive. We tested…”
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Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent by Buchwald, Jadwiga, Chenoweth, Meghan J., Palviainen, Teemu, Zhu, Gu, Benner, Christian, Gordon, Scott, Korhonen, Tellervo, Ripatti, Samuli, Madden, Pamela A. F., Lehtimäki, Terho, Raitakari, Olli T., Salomaa, Veikko, Rose, Richard J., George, Tony P., Lerman, Caryn, Pirinen, Matti, Martin, Nicholas G., Kaprio, Jaakko, Loukola, Anu, Tyndale, Rachel F.

“…Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are altered by the rate of nicotine clearance. Nicotine clearance…”
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Uncovering the complex genetics of human character by Zwir, Igor, Arnedo, Javier, Del-Val, Coral, Pulkki-Råback, Laura, Konte, Bettina, Yang, Sarah S., Romero-Zaliz, Rocio, Hintsanen, Mirka, Cloninger, Kevin M., Garcia, Danilo, Svrakic, Dragan M., Rozsa, Sandor, Martinez, Maribel, Lyytikäinen, Leo-Pekka, Giegling, Ina, Kähönen, Mika, Hernandez-Cuervo, Helena, Seppälä, Ilkka, Raitoharju, Emma, de Erausquin, Gabriel A., Raitakari, Olli, Rujescu, Dan, Postolache, Teodor T., Sung, Joohon, Keltikangas-Järvinen, Liisa, Lehtimäki, Terho, Cloninger, C. Robert

“…Human personality is 30–60% heritable according to twin and adoption studies. Hundreds of genetic variants are expected to influence its complex development,…”
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Three genetic–environmental networks for human personality by Zwir, Igor, Del-Val, Coral, Arnedo, Javier, Pulkki-Råback, Laura, Konte, Bettina, Yang, Sarah S., Romero-Zaliz, Rocio, Hintsanen, Mirka, Cloninger, Kevin M., Garcia, Danilo, Svrakic, Dragan M., Lester, Nigel, Rozsa, Sandor, Mesa, Alberto, Lyytikäinen, Leo-Pekka, Giegling, Ina, Kähönen, Mika, Martinez, Maribel, Seppälä, Ilkka, Raitoharju, Emma, de Erausquin, Gabriel A., Mamah, Daniel, Raitakari, Olli, Rujescu, Dan, Postolache, Teodor T., Gu, C. Charles, Sung, Joohon, Lehtimäki, Terho, Keltikangas-Järvinen, Liisa, Cloninger, C. Robert

“…Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and…”
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Uncovering the complex genetics of human temperament by Zwir, Igor, Arnedo, Javier, Del-Val, Coral, Pulkki-Råback, Laura, Konte, Bettina, Yang, Sarah S., Romero-Zaliz, Rocio, Hintsanen, Mirka, Cloninger, Kevin M., Garcia, Danilo, Svrakic, Dragan M., Rozsa, Sandor, Martinez, Maribel, Lyytikäinen, Leo-Pekka, Giegling, Ina, Kähönen, Mika, Hernandez-Cuervo, Helena, Seppälä, Ilkka, Raitoharju, Emma, de Erausquin, Gabriel A., Raitakari, Olli, Rujescu, Dan, Postolache, Teodor T., Sung, Joohon, Keltikangas-Järvinen, Liisa, Lehtimäki, Terho, Cloninger, C. Robert

“…Experimental studies of learning suggest that human temperament may depend on the molecular mechanisms for associative conditioning, which are highly conserved…”
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Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis by Scholz, Markus, Horn, Katrin, Pott, Janne, Gross, Arnd, Kleber, Marcus E., Delgado, Graciela E., Mishra, Pashupati Prasad, Kirsten, Holger, Gieger, Christian, Müller-Nurasyid, Martina, Tönjes, Anke, Kovacs, Peter, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Gylling, Helena, Baber, Ronny, Isermann, Berend, Stumvoll, Michael, Loeffler, Markus, März, Winfried, Meitinger, Thomas, Peters, Annette, Thiery, Joachim, Teupser, Daniel, Ceglarek, Uta

“…Phytosterol serum concentrations are under tight genetic control. The relationship between phytosterols and coronary artery disease (CAD) is controversially…”
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The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study by Karjalainen, Juho-Pekka, Mononen, Nina, Hutri-Kähönen, Nina, Lehtimäki, Miikael, Juonala, Markus, Ala-Korpela, Mika, Kähönen, Mika, Raitakari, Olli, Lehtimäki, Terho

“…Apolipoprotein E (apoE) is the key regulator of plasma lipids, mediating altered functionalities in lipoprotein metabolism – affecting the risk of coronary…”
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Childhood and Adulthood Passive Smoking and Nonalcoholic Fatty Liver in Midlife: A 31-year Cohort Study by Wu, Feitong, Pahkala, Katja, Juonala, Markus, Jaakkola, Johanna, Rovio, Suvi P., Lehtimäki, Terho, Sabin, Matthew A., Jula, Antti, Hutri-Kähönen, Nina, Laitinen, Tomi, Viikari, Jorma S.A., Magnussen, Costan G., Raitakari, Olli T.

“…Identifying early life risk factors remains key to the prevention of nonalcoholic fatty liver (hereinafter "fatty liver") in adulthood. However, the…”
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Temporal variability of serum miR-191, miR-223, miR-128, and miR-24 in multiple sclerosis: A 4-year follow-up study by Vistbakka, Julia, Sumelahti, Marja-Liisa, Lehtimäki, Terho, Hagman, Sanna

“…Circulating microRNAs (miRNA) are suggested to be a promising biomarker for multiple sclerosis (MS). Previously, miR-128-3p, miR-24-3p, miR-191-5p and…”
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Strong Association of De Novo Copy Number Mutations with Autism by Sebat, Jonathan, Lakshmi, B, Malhotra, Dheeraj, Troge, Jennifer, Lese-Martin, Christa, Walsh, Tom, Yamrom, Boris, Yoon, Seungtai, Krasnitz, Alex, Kendall, Jude, Leotta, Anthony, Pai, Deepa, Zhang, Ray, Lee, Yoon-Ha, Hicks, James, Spence, Sarah J, Lee, Annette T, Puura, Kaija, Lehtimäki, Terho, Ledbetter, David, Gregersen, Peter K, Bregman, Joel, Sutcliffe, James S, Jobanputra, Vaidehi, Chung, Wendy, Warburton, Dorothy, King, Mary-Claire, Skuse, David, Geschwind, Daniel H, Gilliam, T. Conrad, Ye, Kenny, Wigler, Michael

“…We tested the hypothesis that de novo copy number variation (CNV) is associated with autism spectrum disorders (ASDs). We performed comparative genomic…”
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The effect of weight on labor market outcomes: An application of genetic instrumental variables by Böckerman, Petri, Cawley, John, Viinikainen, Jutta, Lehtimäki, Terho, Rovio, Suvi, Seppälä, Ilkka, Pehkonen, Jaakko, Raitakari, Olli

“…This paper contributes to the literature on the labor market consequences of obesity by using a novel instrument: genetic risk score, which reflects the…”
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Circulatory and prostatic tissue lipidomic profiles shifts after high-dose atorvastatin use in men with prostate cancer by Raittinen, Paavo, Niemistö, Kati, Pennanen, Erika, Syvälä, Heimo, Auriola, Seppo, Riikonen, Jarno, Lehtimäki, Terho, Ilmonen, Pauliina, Murtola, Teemu

“…Prostate cancer patients using cholesterol-lowering statins have 30% lower risk of prostate cancer death compared to non-users. The effect is attributed to the…”
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Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health by Marttila, Saara, Rovio, Suvi, Mishra, Pashupati P., Seppälä, Ilkka, Lyytikäinen, Leo-Pekka, Juonala, Markus, Waldenberger, Melanie, Oksala, Niku, Ala-Korpela, Mika, Harville, Emily, Hutri-Kähönen, Nina, Kähönen, Mika, Raitakari, Olli, Lehtimäki, Terho, Raitoharju, Emma

“…Preterm birth (PTB) is associated with increased risk of type 2 diabetes and neurocognitive impairment later in life. We analyzed for the first time the…”
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A meta-analysis of genome-wide association studies identifies multiple longevity genes by Deelen, Joris, Evans, Daniel S., Arking, Dan E., Tesi, Niccolò, Nygaard, Marianne, Liu, Xiaomin, Wojczynski, Mary K., Biggs, Mary L., van der Spek, Ashley, Atzmon, Gil, Ware, Erin B., Sarnowski, Chloé, Smith, Albert V., Seppälä, Ilkka, Cordell, Heather J., Dose, Janina, Amin, Najaf, Arnold, Alice M., Ayers, Kristin L., Barzilai, Nir, Becker, Elizabeth J., Beekman, Marian, Blanché, Hélène, Christensen, Kaare, Christiansen, Lene, Collerton, Joanna C., Cubaynes, Sarah, Cummings, Steven R., Davies, Karen, Debrabant, Birgit, Deleuze, Jean-François, Duncan, Rachel, Faul, Jessica D., Franceschi, Claudio, Galan, Pilar, Gudnason, Vilmundur, Harris, Tamara B., Huisman, Martijn, Hurme, Mikko A., Jagger, Carol, Jansen, Iris, Jylhä, Marja, Kähönen, Mika, Karasik, David, Kardia, Sharon L. R., Kingston, Andrew, Kirkwood, Thomas B. L., Launer, Lenore J., Lehtimäki, Terho, Lieb, Wolfgang, Lyytikäinen, Leo-Pekka, Martin-Ruiz, Carmen, Min, Junxia, Nebel, Almut, Newman, Anne B., Nie, Chao, Nohr, Ellen A., Orwoll, Eric S., Perls, Thomas T., Province, Michael A., Psaty, Bruce M., Raitakari, Olli T., Reinders, Marcel J. T., Robine, Jean-Marie, Rotter, Jerome I., Sebastiani, Paola, Smith, Jennifer, Sørensen, Thorkild I. A., Taylor, Kent D., Uitterlinden, André G., van der Flier, Wiesje, van der Lee, Sven J., van Duijn, Cornelia M., van Heemst, Diana, Vaupel, James W., Weir, David, Ye, Kenny, Zeng, Yi, Zheng, Wanlin, Holstege, Henne, Kiel, Douglas P., Lunetta, Kathryn L., Slagboom, P. Eline, Murabito, Joanne M.

“…Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a…”
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Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation by Bis, Joshua C., Jian, Xueqiu, Kunkle, Brian W., Chen, Yuning, Hamilton-Nelson, Kara L., Bush, William S., Salerno, William J., Lancour, Daniel, Ma, Yiyi, Renton, Alan E., Marcora, Edoardo, Farrell, John J., Zhao, Yi, Qu, Liming, Ahmad, Shahzad, Amin, Najaf, Amouyel, Philippe, Beecham, Gary W., Below, Jennifer E., Campion, Dominique, Cantwell, Laura, Charbonnier, Camille, Chung, Jaeyoon, Crane, Paul K., Cruchaga, Carlos, Cupples, L. Adrienne, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Fulton, Lucinda, Gabriel, Stacey B., Genin, Emmanuelle, Gibbs, Richard A., Goate, Alison, Grenier-Boley, Benjamin, Gupta, Namrata, Haines, Jonathan L., Havulinna, Aki S., Helisalmi, Seppo, Hiltunen, Mikko, Howrigan, Daniel P., Ikram, M. Arfan, Kaprio, Jaakko, Konrad, Jan, Kuzma, Amanda, Lander, Eric S., Lathrop, Mark, Lehtimäki, Terho, Lin, Honghuang, Mattila, Kari, Mayeux, Richard, Muzny, Donna M., Nasser, Waleed, Neale, Benjamin, Nho, Kwangsik, Nicolas, Gaël, Patel, Devanshi, Pericak-Vance, Margaret A., Perola, Markus, Psaty, Bruce M., Quenez, Olivier, Rajabli, Farid, Redon, Richard, Reitz, Christiane, Remes, Anne M., Salomaa, Veikko, Sarnowski, Chloe, Schmidt, Helena, Schmidt, Michael, Schmidt, Reinhold, Soininen, Hilkka, Thornton, Timothy A., Tosto, Giuseppe, Tzourio, Christophe, van der Lee, Sven J., van Duijn, Cornelia M., Valladares, Otto, Vardarajan, Badri, Wang, Li-San, Wang, Weixin, Wijsman, Ellen, Wilson, Richard K., Witten, Daniela, Worley, Kim C., Zhang, Xiaoling, Bellenguez, Celine, Lambert, Jean-Charles, Kurki, Mitja I., Palotie, Aarno, Daly, Mark, Boerwinkle, Eric, Lunetta, Kathryn L., Destefano, Anita L., Dupuis, Josée, Martin, Eden R., Schellenberg, Gerard D., Seshadri, Sudha, Naj, Adam C., Fornage, Myriam, Farrer, Lindsay A.

“…The Alzheimer’s Disease Sequencing Project (ADSP) undertook whole exome sequencing in 5,740 late-onset Alzheimer disease (AD) cases and 5,096 cognitively…”
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Sex differences in coronary atherosclerosis during the pre- and postmenopausal period: The Tampere Sudden Death Study by Hakamaa, Emma, Goebeler, Sirkka, Martiskainen, Mika, Louhelainen, Anne-Mari, Ahinko, Katja, Lehtimäki, Terho, Karhunen, Pekka

“…Women are believed to be protected from coronary heart disease (CHD) by the effects of estrogen but detailed studies on the vessel wall level are missing. We…”
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Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study by Mishra, Binisha H., Mishra, Pashupati P., Raitoharju, Emma, Marttila, Saara, Mononen, Nina, Sievänen, Harri, Viikari, Jorma, Juonala, Markus, Laaksonen, Marika, Hutri-Kähönen, Nina, Kähönen, Mika, Raitakari, Olli T., Lehtimäki, Terho

“…We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene…”
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