Search Results - "Lehrke, M"

Microbiome, diabetes and heart: a novel link? by Kappel, B A, Lehrke, M

“…Patients with type 2 diabetes suffer from a high cardiovascular risk. The underlying pathomechanisms are not fully understood and treatment options are…”
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Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice by Kahles, F., Meyer, C., Diebold, S., Foldenauer, A. C., Stöhr, R., Möllmann, J., Lebherz, C., Findeisen, H. M., Marx, N., Lehrke, M.

“…Recently, glucagon‐like peptide‐1 (GLP‐1) levels have been found to be increased in response to inflammatory stimuli, leading to insulin secretion and…”
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The prothrombotic risk of patients with type II diabetes in stable and unstable coronary artery disease by Berger, M, Lysaja, K, Lehrke, M, Marx, N, Schütt, K

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Mikrobiom, Diabetes und Herz: neue Zusammenhänge? by Kappel, B. A., Lehrke, M.

“…Zusammenfassung Patienten mit Typ-2-Diabetes haben ein hohes kardiovaskuläres Risiko. Die zugrunde liegenden Pathomechanismen sind bisher nicht hinreichend…”
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Diabetes und Herz by Lehrke, M.

“…Zusammenfassung Hintergrund Diabetes mellitus bleibt ein führender Risikofaktor für kardiovaskuläre Ereignisse. Bisherige Diabetestherapie Für die Behandlung…”
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Herz und Diabetes by Lehrke, M.

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Cardiovascular effects of incretin-based therapies by Lehrke, M, Marx, N

“…Pharmacological modulation of the glucagon-like peptide-1 (GLP-1) system has emerged as a new therapeutic option for treatment of diabetes mellitus. In…”
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Kardiovaskuläre Effekte inkretinbasierter Therapien by Lehrke, M., Marx, N.

“…Zusammenfassung Eine pharmakologische Aktivierung des GLP-1-Systems hat sich als ein neuer Ansatz in der Therapie des Diabetes mellitus etabliert. Neben einer…”
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The Many Faces of PPARγ by Lehrke, Michael, Lazar, Mitchell A.

“…In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor…”
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Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels by Otto, C, Otto, B, Göke, B, Pfeiffer, A F H, Lehrke, M, Vogeser, M, Spranger, J, Parhofer, K G

“…Glitazones increase the secretion of the adipocyte-derived hormone adiponectin. Furthermore, the gastric signal peptide ghrelin is known to suppress…”
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The SGLT2 inhibitor ertugliflozin causes a switch of cardiac substrate utilization leading to reduced cardiac mTOR-signaling, unfolded protein response and apoptosis by Moellmann, J, Mann, P, Krueger, K, Klinkhammer, B, Boor, P, Marx, N, Lehrke, M

“…Abstract Introduction SGLT2 inhibitors reduce hospitalization for heart failure in patients with and without diabetes. The underlying mechanisms remain…”
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Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology by Maack, Christoph, Lehrke, Michael, Backs, Johannes, Heinzel, Frank R, Hulot, Jean-Sebastien, Marx, Nikolaus, Paulus, Walter J, Rossignol, Patrick, Taegtmeyer, Heinrich, Bauersachs, Johann, Bayes-Genis, Antoni, Brutsaert, Dirk, Bugger, Heiko, Clarke, Kieran, Cosentino, Francesco, De Keulenaer, Gilles, Dei Cas, Alessandra, González, Arantxa, Huelsmann, Martin, Iaccarino, Guido, Lunde, Ida Gjervold, Lyon, Alexander R, Pollesello, Piero, Rena, Graham, Riksen, Niels P, Rosano, Giuseppe, Staels, Bart, van Laake, Linda W, Wanner, Christoph, Farmakis, Dimitrios, Filippatos, Gerasimos, Ruschitzka, Frank, Seferovic, Petar, de Boer, Rudolf A, Heymans, Stephane

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Outcome of transcutaneous edge-to-edge mitral valve repair in patients with diabetes mellitus: results from a real-world cohort by Kirschfink, A, Alachkar, M N, Vogt, F, Schroeder, J, Lehrke, M, Frick, M, Almalla, M, Marx, N, Altiok, E

“…Abstract Background Transcutaneous edge-to-edge repair (TEER) has become a treatment option for selected patients with severe mitral regurgitation (MR)…”
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HSD3 Treatment and Associated Outcomes of Type-2 Diabetes Mellitus Patients With a Cardiovascular Comorbidity and Comparison With Guideline Recommendations: A German Claims Data Analysis by Gabler, M., Duerschmied, D., Grond, M., Lehrke, M., Martin, S., Tröbs, S.O., Schultze, M., Kossack, N., Richter, L., Aberle, J.

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IL-6 dependent GLP-1 secretion during acute inflammation by Kahles, F, Meyer, C, Möllmann, J, Diebold, S, Findeisen, H M, Lebherz, C, Trautwein, C, Koch, A, Tacke, F, Marx, N, Lehrke, M

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Effect of atorvastatin on lipid parameters, LDL subtype distribution, hemorrheological parameters and adhesion molecule concentrations in patients with hypertriglyceridemia by Empen, K., Geiss, H.-C., Lehrke, M., Otto, C., Schwandt, P., Parhofer, K.G.

“…Hypertriglyceridemia is a risk factor for atherosclerosis that is typically associated with high concentrations of adhesion molecules, impaired hemorrheology…”
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Adjustment of the SMART risk score by bioactive adrenomedullin enables a more accurate prediction of mortality in patients with ASCVD by Kurt, B, Rau, M, Hartmann, O, Lobo De Sa, F, Moellmann, J, Spiesshoefer, J, Milzi, A, Schwarz, M, Thiele, K, Hartmann, N, Van Der Vorst, E, Dahl, E, Marx, N, Lehrke, M, Kahles, F

“…Abstract Background Bioactive adrenomedullin 1-52 (bio-ADM) is a dynamic blood biomarker for real-time assessment of endothelial function. Bio-ADM was recently…”
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GLP-2 predicts cardiovascular outcomes in patients with myocardial infarction and increases atherosclerosis in mice by Kahles, F, Sausen, M, Quintana, L, Rueckbeil, M, Idel, P, Mertens, R, Just, S, Arrivas, M C, Moellmann, J, Biener, M, Giannitsis, E, Katus, H A, Drucker, D J, Marx, N, Lehrke, M

“…Abstract Background GLP-1 and GLP-2 (glucagon-like peptide-1/2) are incretin hormones that are co-secreted from intestinal L-cells in response to food intake…”
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The gut hormone GIP predicts CV prognosis in patients with acute myocardial infarction by Kahles, F, Rueckbeil, M V, Arrivas, M C, Mertens, R W, Moellmann, J, Biener, M, Giannitsis, E, Katus, H A, Marx, N, Lehrke, M

“…Abstract Background The gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by…”
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GLP-2 as an indicator and modulator of acute inflammation improves cardiac function and survival in sepsis by Kahles, F, Mertens, R, Diebold, S, Arrivas, M C, Moellmann, J, Steitz, J, Mirzaei, Y, Sandoval, D, Martin, L, Schuerholz, T, Koch, A, Tacke, F, Drucker, D J, Marx, N, Lehrke, M

“…Abstract Purpose GLP-1 and GLP-2 (glucagon-like peptide-1/2) are gut hormones secreted in response to food. While GLP-1 controls glucose metabolism, GLP-2 is a…”
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